Activation of the protein kinase a signal transduction pathway by granulocyte‐macrophage colony‐stimulating factor or by genetic manipulation reduces cytoskeletal organization in lewis lung carcinoma variants

Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) that is produced by metastatic Lewis lung carcinoma (LLC‐LN7) cells functions as an autocrine stimulator of tumor‐cell motility through protein kinase A (PKA) signal transduction. This GM‐CSF‐mediated enhancement of LLC‐LN7 cell motility coin...

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Veröffentlicht in:	International journal of cancer 1994-02, Vol.56 (3), p.446-451
Hauptverfasser:	Young, M. Rita I., Charboneau, Susan, Lozano, Yvonne, Djordjevic, Andelka, Young, Melvin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Adhesion Cell Line Cell Movement - drug effects Cyclic AMP-Dependent Protein Kinases - biosynthesis Cyclic AMP-Dependent Protein Kinases - metabolism Cytoskeleton - drug effects Cytoskeleton - ultrastructure Dissemination Genetic Variation Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Lung Neoplasms - pathology Lung Neoplasms - physiopathology Lung Neoplasms - ultrastructure Macromolecular Substances Medical sciences Mice Neoplasm Metastasis Signal Transduction - drug effects Signal Transduction - physiology Transfection Tumor cell Tumor Cells, Cultured Tumors Vimentin - analysis
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