Decreased bone mineral density in children with phenylketonuria
Previous studies have suggested that children with phenylketonuria (PKU) have a reduction in bone mineralization compared with control subjects. To investigate this, bone mineral density (BMD) of the total body (TBMD) was measured in 32 prepubertal children with PKU and in 95 age-matched control sub...
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| Veröffentlicht in: | The American journal of clinical nutrition 1994-02, Vol.59 (2), p.419-422 |
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| creator | Allen, JR Humphries, I R J Waters, DL Roberts, D C K Lipson, AH Howman-Giles, RG Gaskin, KJ |
| description | Previous studies have suggested that children with phenylketonuria (PKU) have a reduction in bone mineralization compared with control subjects. To investigate this, bone mineral density (BMD) of the total body (TBMD) was measured in 32 prepubertal children with PKU and in 95 age-matched control subjects. Spine bone mineral density (SBMD) was also recorded in a subset, 24 with PKU and 55 control subjects. The effect of dietary intake on bone mass was assessed in 30 of the children with PKU and in 12 control subjects. In the children with PKU, TBMD and SBMD were significantly lower than in the control subjects after adjustment for height and weight (P = 0.03 and P = 0.003, respectively). The children with PKU had a higher intake of calcium (P < 0.0001), phosphorus (P = 0.0002), and magnesium (P < 0.0001), suggesting that their lower BMD occurred despite an adequate diet based on current recommendations. Further study is needed to establish the cause of this deficit in bone mass and the benefit of additional nutritional support to reverse this problem. |
| doi_str_mv | 10.1093/ajcn/59.2.419 |
| format | Article |
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To investigate this, bone mineral density (BMD) of the total body (TBMD) was measured in 32 prepubertal children with PKU and in 95 age-matched control subjects. Spine bone mineral density (SBMD) was also recorded in a subset, 24 with PKU and 55 control subjects. The effect of dietary intake on bone mass was assessed in 30 of the children with PKU and in 12 control subjects. In the children with PKU, TBMD and SBMD were significantly lower than in the control subjects after adjustment for height and weight (P = 0.03 and P = 0.003, respectively). The children with PKU had a higher intake of calcium (P < 0.0001), phosphorus (P = 0.0002), and magnesium (P < 0.0001), suggesting that their lower BMD occurred despite an adequate diet based on current recommendations. Further study is needed to establish the cause of this deficit in bone mass and the benefit of additional nutritional support to reverse this problem.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/59.2.419</identifier><identifier>PMID: 8310995</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Absorptiometry, Photon ; Aminoacid disorders ; Analysis of Variance ; AUSTRALIA ; AUSTRALIE ; Biological and medical sciences ; Body Height ; Bone Density ; Bones ; CALCIO ; CALCIUM ; calcium (dietary) ; Child ; children ; Children & youth ; CONTENIDO DE CENIZA ; DENSIDAD ; DENSITE ; Diet ; DIETA ; ENFANT ; Errors of metabolism ; Female ; FOSFORO ; HUESOS ; Humans ; INGESTION DE NUTRIENTES ; INGESTION DE SUBSTANCES NUTRITIVES ; MAGNESIO ; MAGNESIUM ; magnesium (dietary) ; Male ; Medical disorders ; Medical research ; Medical sciences ; Metabolic diseases ; MINERALES ; Minerals ; MINERAUX ; NINOS ; Phenylalanine - blood ; phenylketonuria ; Phenylketonurias - physiopathology ; PHOSPHORE ; phosphorus (dietary) ; REGIME ALIMENTAIRE ; Regression Analysis ; TENEUR EN CENDRES ; TRASTORNOS METABOLICOS ; TROUBLE DU METABOLISME</subject><ispartof>The American journal of clinical nutrition, 1994-02, Vol.59 (2), p.419-422</ispartof><rights>1994 American Society for Nutrition.</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Feb 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-d3367bafa9f5320b02778599e3846a78387843f6e5fd8e4dea4ed2c974b769373</citedby><cites>FETCH-LOGICAL-c450t-d3367bafa9f5320b02778599e3846a78387843f6e5fd8e4dea4ed2c974b769373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3936998$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8310995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, JR</creatorcontrib><creatorcontrib>Humphries, I R J</creatorcontrib><creatorcontrib>Waters, DL</creatorcontrib><creatorcontrib>Roberts, D C K</creatorcontrib><creatorcontrib>Lipson, AH</creatorcontrib><creatorcontrib>Howman-Giles, RG</creatorcontrib><creatorcontrib>Gaskin, KJ</creatorcontrib><title>Decreased bone mineral density in children with phenylketonuria</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Previous studies have suggested that children with phenylketonuria (PKU) have a reduction in bone mineralization compared with control subjects. To investigate this, bone mineral density (BMD) of the total body (TBMD) was measured in 32 prepubertal children with PKU and in 95 age-matched control subjects. Spine bone mineral density (SBMD) was also recorded in a subset, 24 with PKU and 55 control subjects. The effect of dietary intake on bone mass was assessed in 30 of the children with PKU and in 12 control subjects. In the children with PKU, TBMD and SBMD were significantly lower than in the control subjects after adjustment for height and weight (P = 0.03 and P = 0.003, respectively). The children with PKU had a higher intake of calcium (P < 0.0001), phosphorus (P = 0.0002), and magnesium (P < 0.0001), suggesting that their lower BMD occurred despite an adequate diet based on current recommendations. Further study is needed to establish the cause of this deficit in bone mass and the benefit of additional nutritional support to reverse this problem.</description><subject>Absorptiometry, Photon</subject><subject>Aminoacid disorders</subject><subject>Analysis of Variance</subject><subject>AUSTRALIA</subject><subject>AUSTRALIE</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Bone Density</subject><subject>Bones</subject><subject>CALCIO</subject><subject>CALCIUM</subject><subject>calcium (dietary)</subject><subject>Child</subject><subject>children</subject><subject>Children & youth</subject><subject>CONTENIDO DE CENIZA</subject><subject>DENSIDAD</subject><subject>DENSITE</subject><subject>Diet</subject><subject>DIETA</subject><subject>ENFANT</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>FOSFORO</subject><subject>HUESOS</subject><subject>Humans</subject><subject>INGESTION DE NUTRIENTES</subject><subject>INGESTION DE SUBSTANCES NUTRITIVES</subject><subject>MAGNESIO</subject><subject>MAGNESIUM</subject><subject>magnesium (dietary)</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>MINERALES</subject><subject>Minerals</subject><subject>MINERAUX</subject><subject>NINOS</subject><subject>Phenylalanine - blood</subject><subject>phenylketonuria</subject><subject>Phenylketonurias - physiopathology</subject><subject>PHOSPHORE</subject><subject>phosphorus (dietary)</subject><subject>REGIME ALIMENTAIRE</subject><subject>Regression Analysis</subject><subject>TENEUR EN CENDRES</subject><subject>TRASTORNOS METABOLICOS</subject><subject>TROUBLE DU METABOLISME</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAURUVoSKdpltkUCiaU7jzRh2XprUpJ2zQQyKLJWsjSc0dTjzyV7IT591GYIYtCV29xz7tcDiHnjC4ZBXFp1y5eSljyZcPgiCwYCF0LTtUbsqCU8hpYK9-SdzmvKWW80e0JOdGi_IJckC_f0CW0GX3VjRGrTYiY7FB5jDlMuyrEyq3C4BPG6ilMq2q7wrgb_uA0xjkF-54c93bIeHa4p-Thx_f7q5_17d31zdXX29o1kk61F6JVne0t9LJs6yhXSksAFLpprdJCK92IvkXZe42NR9ug5w5U06kWhBKn5PO-d5vGvzPmyWxCdjgMNuI4Z6NaIakSvIAX_4DrcU6xbDNcMGBaSFageg-5NOacsDfbFDY27Qyj5sWqebFqJBhuitXCfzyUzt0G_St90FjyT4fcZmeHPtnoQn7FBIgWQBfswx7r7Wjs71SQh18gSwXQEqp9iEXjY8BksgsYHfqQ0E3Gj-E_654BZQKZ3w</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Allen, JR</creator><creator>Humphries, I R J</creator><creator>Waters, DL</creator><creator>Roberts, D C K</creator><creator>Lipson, AH</creator><creator>Howman-Giles, RG</creator><creator>Gaskin, KJ</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>Decreased bone mineral density in children with phenylketonuria</title><author>Allen, JR ; Humphries, I R J ; Waters, DL ; Roberts, D C K ; Lipson, AH ; Howman-Giles, RG ; Gaskin, KJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-d3367bafa9f5320b02778599e3846a78387843f6e5fd8e4dea4ed2c974b769373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Absorptiometry, Photon</topic><topic>Aminoacid disorders</topic><topic>Analysis of Variance</topic><topic>AUSTRALIA</topic><topic>AUSTRALIE</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Bone Density</topic><topic>Bones</topic><topic>CALCIO</topic><topic>CALCIUM</topic><topic>calcium (dietary)</topic><topic>Child</topic><topic>children</topic><topic>Children & youth</topic><topic>CONTENIDO DE CENIZA</topic><topic>DENSIDAD</topic><topic>DENSITE</topic><topic>Diet</topic><topic>DIETA</topic><topic>ENFANT</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>FOSFORO</topic><topic>HUESOS</topic><topic>Humans</topic><topic>INGESTION DE NUTRIENTES</topic><topic>INGESTION DE SUBSTANCES NUTRITIVES</topic><topic>MAGNESIO</topic><topic>MAGNESIUM</topic><topic>magnesium (dietary)</topic><topic>Male</topic><topic>Medical disorders</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>MINERALES</topic><topic>Minerals</topic><topic>MINERAUX</topic><topic>NINOS</topic><topic>Phenylalanine - blood</topic><topic>phenylketonuria</topic><topic>Phenylketonurias - physiopathology</topic><topic>PHOSPHORE</topic><topic>phosphorus (dietary)</topic><topic>REGIME ALIMENTAIRE</topic><topic>Regression Analysis</topic><topic>TENEUR EN CENDRES</topic><topic>TRASTORNOS METABOLICOS</topic><topic>TROUBLE DU METABOLISME</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, JR</creatorcontrib><creatorcontrib>Humphries, I R J</creatorcontrib><creatorcontrib>Waters, DL</creatorcontrib><creatorcontrib>Roberts, D C K</creatorcontrib><creatorcontrib>Lipson, AH</creatorcontrib><creatorcontrib>Howman-Giles, RG</creatorcontrib><creatorcontrib>Gaskin, KJ</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, JR</au><au>Humphries, I R J</au><au>Waters, DL</au><au>Roberts, D C K</au><au>Lipson, AH</au><au>Howman-Giles, RG</au><au>Gaskin, KJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased bone mineral density in children with phenylketonuria</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>59</volume><issue>2</issue><spage>419</spage><epage>422</epage><pages>419-422</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Previous studies have suggested that children with phenylketonuria (PKU) have a reduction in bone mineralization compared with control subjects. To investigate this, bone mineral density (BMD) of the total body (TBMD) was measured in 32 prepubertal children with PKU and in 95 age-matched control subjects. Spine bone mineral density (SBMD) was also recorded in a subset, 24 with PKU and 55 control subjects. The effect of dietary intake on bone mass was assessed in 30 of the children with PKU and in 12 control subjects. In the children with PKU, TBMD and SBMD were significantly lower than in the control subjects after adjustment for height and weight (P = 0.03 and P = 0.003, respectively). The children with PKU had a higher intake of calcium (P < 0.0001), phosphorus (P = 0.0002), and magnesium (P < 0.0001), suggesting that their lower BMD occurred despite an adequate diet based on current recommendations. Further study is needed to establish the cause of this deficit in bone mass and the benefit of additional nutritional support to reverse this problem.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8310995</pmid><doi>10.1093/ajcn/59.2.419</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 1994-02, Vol.59 (2), p.419-422 |
| issn | 0002-9165 1938-3207 |
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| subjects | Absorptiometry, Photon Aminoacid disorders Analysis of Variance AUSTRALIA AUSTRALIE Biological and medical sciences Body Height Bone Density Bones CALCIO CALCIUM calcium (dietary) Child children Children & youth CONTENIDO DE CENIZA DENSIDAD DENSITE Diet DIETA ENFANT Errors of metabolism Female FOSFORO HUESOS Humans INGESTION DE NUTRIENTES INGESTION DE SUBSTANCES NUTRITIVES MAGNESIO MAGNESIUM magnesium (dietary) Male Medical disorders Medical research Medical sciences Metabolic diseases MINERALES Minerals MINERAUX NINOS Phenylalanine - blood phenylketonuria Phenylketonurias - physiopathology PHOSPHORE phosphorus (dietary) REGIME ALIMENTAIRE Regression Analysis TENEUR EN CENDRES TRASTORNOS METABOLICOS TROUBLE DU METABOLISME |
| title | Decreased bone mineral density in children with phenylketonuria |
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