Receptor-independent activation of guanine nucleotide-binding regulatory proteins by terminal complement complexes

Activation of heterotrimeric guanine nucleotide-binding proteins (G proteins) by terminal complement complexes (TCC) was investigated on human lymphoblastoid B-cell line JY25 and its mutant JY5 deficient in glycosylphosphatidylinositol-anchored proteins. TCC assembly achieved by antibody-dependent a...

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Veröffentlicht in:	The Journal of biological chemistry 1994-02, Vol.269 (6), p.4417-4423
Hauptverfasser:	NICULESCU, F, RUS, H, SHIN, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - metabolism Biological and medical sciences Cell Line Complement Complement Activation Complement Membrane Attack Complex - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Fundamental immunology GTP-Binding Proteins - metabolism Guanosine Triphosphate - metabolism Humans In Vitro Techniques Molecular immunology Pertussis Toxin Poly(ADP-ribose) Polymerases - metabolism Signal Transduction Virulence Factors, Bordetella - pharmacology
Online-Zugang:	Volltext
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