Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus

The presence of retinoblastoma (RB) protein was evaluated by immunohistochemical staining and correlated with loss of heterozygosity (LOH) at the RB locus in 52 primary epithelial ovarian carcinomas. Forty-eight tumors were informative at the RB locus by molecular genetic analysis. Twenty-five tumor...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-02, Vol.54 (3), p.610-613
Hauptverfasser:	DODSON, M. K, CLIBY, W. A, HONG-JI XU, DELACEY, K. A, SHI-XUE HU, KEENEY, G. L, JIAN LI, PODRATZ, K. C, JENKINS, R. B, BENEDICT, W. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Epithelium - pathology Female Female genital diseases Gene Deletion Genes, Retinoblastoma - genetics Gynecology. Andrology. Obstetrics Heterozygote Humans Immunohistochemistry Medical sciences Neoplasm Invasiveness Ovarian Neoplasms - chemistry Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Retinoblastoma Protein - analysis Retinoblastoma Protein - genetics Retinoblastoma Protein - physiology Tumors
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