Tricyclic Antidepressants: Evidence for an Intraneuronal Site of Action

Desipramine, a tricyclic antidepressant drug, almost completely prevents the accumulation of tritiated norepinephrine by sympathetic neurons of the rat heart after the injection of a tracer dose of the labeled amine. However, desipramine does not alter the accumulation of norepinephrine after the in...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1969-04, Vol.164 (3878), p.437-439
Hauptverfasser:	Reid, W. D., Stefano, F. J. E., Kurzepa, S., Brodie, B. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Animals Antidepressants Depression, Chemical Desipramine - pharmacology Dosage Hammers Heart - innervation Intraperitoneal injections Intravenous injections Male Neurons Neurons - drug effects Neurons - metabolism Neurotransmitter agents Norepinephrine Norepinephrine - metabolism Rats Reserpine - antagonists & inhibitors Sympathetic Nervous System - metabolism Tricyclic antidepressive agents Tritium
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