Anti-β-receptor antibodies in familial cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms
The presence of β-receptor autoantibodies and their relationship to restriction fragment length polymorphisms of the human leukocyte antigen (HLA) class II genes were studied in 42 affected and unaffected members of a family with a heritable disorder of the conduction system and cardiac muscle. Anti...
Gespeichert in:
| Veröffentlicht in: | The American heart journal 1994-02, Vol.127 (2), p.382-386 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 386 |
|---|---|
| container_issue | 2 |
| container_start_page | 382 |
| container_title | The American heart journal |
| container_volume | 127 |
| creator | Limas, Catherine Limas, Constantinos J. Boudoulas, Harisios Bair, Robert Graber, Harry Sparks, Libby Wooley, Charles F. |
| description | The presence of β-receptor autoantibodies and their relationship to restriction fragment length polymorphisms of the human leukocyte antigen (HLA) class II genes were studied in 42 affected and unaffected members of a family with a heritable disorder of the conduction system and cardiac muscle. Antibodies were detected in 34% of all members (59% of affected and 22% of unaffected; p < 0.01). Significant differences between affected and unaffected individuals and between anti-β-receptor antibody positive and negative individuals were noted in the prevalence of polymorphisms obtained with Taq I for the HLA-DRβ and HLA-DQα genes. In affected individuals, there was a strong positive correlation between these polymorphisms and the presence of anti-β-receptor antibodies. These results suggest that autoimmune mechanisms under the control of the class II genes play an important role in the pathogenesis of familial cardiomyopathy. |
| doi_str_mv | 10.1016/0002-8703(94)90128-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76344728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002870394901287</els_id><sourcerecordid>76344728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-6a76aac2480b41f071971b7cbef5d3a9c5de62857d1a95d7f33105d47ab864343</originalsourceid><addsrcrecordid>eNqFkcuKFDEUhoMoY0_rGygElEEX0aQqt3IhNO1lhAZRdB1SySk7Q1WlJqlW-rV8EJ_JtN30woWucjnf-Tn_-RF6xOgLRpl8SSmtiFa0ftbw5w1llSbqDlow2igiFed30eKM3EeXOd-Up6y0vEAXqqGi4mKBhtU4B_LrJ0ngYJpjwrZ8tNEHyDiMuLND6IPtsbPJhzjs42Tn7f4VXseUoLdziCP-EeYtvt6syJvPpd0fr5_wNxgBT7HfDzFN25CH_ADd62yf4eHpXKKv795-WV-Tzcf3H9arDXGci5lIq6S1ruKatpx1VLFGsVa5Fjrha9s44aEYEcoz2wivurpmVHiubKslr3m9RFdH3SnF2x3k2QwhO-h7O0LcZaNkzbmq9H9BJjUTsuBL9OQv8Cbu0lhMmEoVKaG1EoXiR8qlmHOCzkwpDDbtDaPmEJo5JGIOiZiGmz-hGVXaHp_Ed-0A_tx0SqnUn57qNjvbd8mOLuQzVpftyOZg5vURg7La7wGSyS7A6MCHku5sfAz_nuM3rE2yEQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2747258875</pqid></control><display><type>article</type><title>Anti-β-receptor antibodies in familial cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Limas, Catherine ; Limas, Constantinos J. ; Boudoulas, Harisios ; Bair, Robert ; Graber, Harry ; Sparks, Libby ; Wooley, Charles F.</creator><creatorcontrib>Limas, Catherine ; Limas, Constantinos J. ; Boudoulas, Harisios ; Bair, Robert ; Graber, Harry ; Sparks, Libby ; Wooley, Charles F.</creatorcontrib><description>The presence of β-receptor autoantibodies and their relationship to restriction fragment length polymorphisms of the human leukocyte antigen (HLA) class II genes were studied in 42 affected and unaffected members of a family with a heritable disorder of the conduction system and cardiac muscle. Antibodies were detected in 34% of all members (59% of affected and 22% of unaffected; p < 0.01). Significant differences between affected and unaffected individuals and between anti-β-receptor antibody positive and negative individuals were noted in the prevalence of polymorphisms obtained with Taq I for the HLA-DRβ and HLA-DQα genes. In affected individuals, there was a strong positive correlation between these polymorphisms and the presence of anti-β-receptor antibodies. These results suggest that autoimmune mechanisms under the control of the class II genes play an important role in the pathogenesis of familial cardiomyopathy.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(94)90128-7</identifier><identifier>PMID: 7905245</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antibodies ; Antigens ; Arrhythmias, Cardiac - genetics ; Arrhythmias, Cardiac - immunology ; Autoantibodies ; Autoantibodies - genetics ; Biological and medical sciences ; Biomarkers ; Cardiac muscle ; Cardiology. Vascular system ; Cardiomegaly - genetics ; Cardiomegaly - immunology ; Cardiomyopathy ; Cardiomyopathy, Dilated - genetics ; Cardiomyopathy, Dilated - immunology ; Disease Susceptibility - immunology ; Female ; Gene polymorphism ; Genes ; Genes, MHC Class II - genetics ; Genetic Predisposition to Disease ; Heart ; Heart Block - genetics ; Heart Block - immunology ; Heart Failure - genetics ; Heart Failure - immunology ; Histocompatibility antigen HLA ; HLA-DQ Antigens - genetics ; HLA-DR Antigens - genetics ; HLA-DR4 Antigen - genetics ; Humans ; Leukocytes ; Male ; Medical sciences ; Muscles ; Myocarditis. Cardiomyopathies ; Pathogenesis ; Phenotype ; Polymorphism, Genetic - genetics ; Polymorphism, Restriction Fragment Length ; Receptors ; Receptors, Adrenergic, beta - genetics ; Receptors, Adrenergic, beta - immunology</subject><ispartof>The American heart journal, 1994-02, Vol.127 (2), p.382-386</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-6a76aac2480b41f071971b7cbef5d3a9c5de62857d1a95d7f33105d47ab864343</citedby><cites>FETCH-LOGICAL-c445t-6a76aac2480b41f071971b7cbef5d3a9c5de62857d1a95d7f33105d47ab864343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2747258875?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3971698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7905245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Limas, Catherine</creatorcontrib><creatorcontrib>Limas, Constantinos J.</creatorcontrib><creatorcontrib>Boudoulas, Harisios</creatorcontrib><creatorcontrib>Bair, Robert</creatorcontrib><creatorcontrib>Graber, Harry</creatorcontrib><creatorcontrib>Sparks, Libby</creatorcontrib><creatorcontrib>Wooley, Charles F.</creatorcontrib><title>Anti-β-receptor antibodies in familial cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>The presence of β-receptor autoantibodies and their relationship to restriction fragment length polymorphisms of the human leukocyte antigen (HLA) class II genes were studied in 42 affected and unaffected members of a family with a heritable disorder of the conduction system and cardiac muscle. Antibodies were detected in 34% of all members (59% of affected and 22% of unaffected; p < 0.01). Significant differences between affected and unaffected individuals and between anti-β-receptor antibody positive and negative individuals were noted in the prevalence of polymorphisms obtained with Taq I for the HLA-DRβ and HLA-DQα genes. In affected individuals, there was a strong positive correlation between these polymorphisms and the presence of anti-β-receptor antibodies. These results suggest that autoimmune mechanisms under the control of the class II genes play an important role in the pathogenesis of familial cardiomyopathy.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Arrhythmias, Cardiac - genetics</subject><subject>Arrhythmias, Cardiac - immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cardiac muscle</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomegaly - genetics</subject><subject>Cardiomegaly - immunology</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Dilated - genetics</subject><subject>Cardiomyopathy, Dilated - immunology</subject><subject>Disease Susceptibility - immunology</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genes, MHC Class II - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Heart</subject><subject>Heart Block - genetics</subject><subject>Heart Block - immunology</subject><subject>Heart Failure - genetics</subject><subject>Heart Failure - immunology</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Pathogenesis</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Receptors</subject><subject>Receptors, Adrenergic, beta - genetics</subject><subject>Receptors, Adrenergic, beta - immunology</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkcuKFDEUhoMoY0_rGygElEEX0aQqt3IhNO1lhAZRdB1SySk7Q1WlJqlW-rV8EJ_JtN30woWucjnf-Tn_-RF6xOgLRpl8SSmtiFa0ftbw5w1llSbqDlow2igiFed30eKM3EeXOd-Up6y0vEAXqqGi4mKBhtU4B_LrJ0ngYJpjwrZ8tNEHyDiMuLND6IPtsbPJhzjs42Tn7f4VXseUoLdziCP-EeYtvt6syJvPpd0fr5_wNxgBT7HfDzFN25CH_ADd62yf4eHpXKKv795-WV-Tzcf3H9arDXGci5lIq6S1ruKatpx1VLFGsVa5Fjrha9s44aEYEcoz2wivurpmVHiubKslr3m9RFdH3SnF2x3k2QwhO-h7O0LcZaNkzbmq9H9BJjUTsuBL9OQv8Cbu0lhMmEoVKaG1EoXiR8qlmHOCzkwpDDbtDaPmEJo5JGIOiZiGmz-hGVXaHp_Ed-0A_tx0SqnUn57qNjvbd8mOLuQzVpftyOZg5vURg7La7wGSyS7A6MCHku5sfAz_nuM3rE2yEQ</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Limas, Catherine</creator><creator>Limas, Constantinos J.</creator><creator>Boudoulas, Harisios</creator><creator>Bair, Robert</creator><creator>Graber, Harry</creator><creator>Sparks, Libby</creator><creator>Wooley, Charles F.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>Anti-β-receptor antibodies in familial cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms</title><author>Limas, Catherine ; Limas, Constantinos J. ; Boudoulas, Harisios ; Bair, Robert ; Graber, Harry ; Sparks, Libby ; Wooley, Charles F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-6a76aac2480b41f071971b7cbef5d3a9c5de62857d1a95d7f33105d47ab864343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Arrhythmias, Cardiac - genetics</topic><topic>Arrhythmias, Cardiac - immunology</topic><topic>Autoantibodies</topic><topic>Autoantibodies - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cardiac muscle</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomegaly - genetics</topic><topic>Cardiomegaly - immunology</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Dilated - genetics</topic><topic>Cardiomyopathy, Dilated - immunology</topic><topic>Disease Susceptibility - immunology</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genes, MHC Class II - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Heart</topic><topic>Heart Block - genetics</topic><topic>Heart Block - immunology</topic><topic>Heart Failure - genetics</topic><topic>Heart Failure - immunology</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Pathogenesis</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Receptors</topic><topic>Receptors, Adrenergic, beta - genetics</topic><topic>Receptors, Adrenergic, beta - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Limas, Catherine</creatorcontrib><creatorcontrib>Limas, Constantinos J.</creatorcontrib><creatorcontrib>Boudoulas, Harisios</creatorcontrib><creatorcontrib>Bair, Robert</creatorcontrib><creatorcontrib>Graber, Harry</creatorcontrib><creatorcontrib>Sparks, Libby</creatorcontrib><creatorcontrib>Wooley, Charles F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Limas, Catherine</au><au>Limas, Constantinos J.</au><au>Boudoulas, Harisios</au><au>Bair, Robert</au><au>Graber, Harry</au><au>Sparks, Libby</au><au>Wooley, Charles F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-β-receptor antibodies in familial cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>127</volume><issue>2</issue><spage>382</spage><epage>386</epage><pages>382-386</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>The presence of β-receptor autoantibodies and their relationship to restriction fragment length polymorphisms of the human leukocyte antigen (HLA) class II genes were studied in 42 affected and unaffected members of a family with a heritable disorder of the conduction system and cardiac muscle. Antibodies were detected in 34% of all members (59% of affected and 22% of unaffected; p < 0.01). Significant differences between affected and unaffected individuals and between anti-β-receptor antibody positive and negative individuals were noted in the prevalence of polymorphisms obtained with Taq I for the HLA-DRβ and HLA-DQα genes. In affected individuals, there was a strong positive correlation between these polymorphisms and the presence of anti-β-receptor antibodies. These results suggest that autoimmune mechanisms under the control of the class II genes play an important role in the pathogenesis of familial cardiomyopathy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7905245</pmid><doi>10.1016/0002-8703(94)90128-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8703 |
| ispartof | The American heart journal, 1994-02, Vol.127 (2), p.382-386 |
| issn | 0002-8703 1097-6744 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76344728 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Antibodies Antigens Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - immunology Autoantibodies Autoantibodies - genetics Biological and medical sciences Biomarkers Cardiac muscle Cardiology. Vascular system Cardiomegaly - genetics Cardiomegaly - immunology Cardiomyopathy Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - immunology Disease Susceptibility - immunology Female Gene polymorphism Genes Genes, MHC Class II - genetics Genetic Predisposition to Disease Heart Heart Block - genetics Heart Block - immunology Heart Failure - genetics Heart Failure - immunology Histocompatibility antigen HLA HLA-DQ Antigens - genetics HLA-DR Antigens - genetics HLA-DR4 Antigen - genetics Humans Leukocytes Male Medical sciences Muscles Myocarditis. Cardiomyopathies Pathogenesis Phenotype Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Receptors Receptors, Adrenergic, beta - genetics Receptors, Adrenergic, beta - immunology |
| title | Anti-β-receptor antibodies in familial cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T16%3A32%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-%CE%B2-receptor%20antibodies%20in%20familial%20cardiomyopathy:%20Correlation%20with%20HLA-DR%20and%20HLA-DQ%20gene%20polymorphisms&rft.jtitle=The%20American%20heart%20journal&rft.au=Limas,%20Catherine&rft.date=1994-02-01&rft.volume=127&rft.issue=2&rft.spage=382&rft.epage=386&rft.pages=382-386&rft.issn=0002-8703&rft.eissn=1097-6744&rft.coden=AHJOA2&rft_id=info:doi/10.1016/0002-8703(94)90128-7&rft_dat=%3Cproquest_cross%3E76344728%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2747258875&rft_id=info:pmid/7905245&rft_els_id=0002870394901287&rfr_iscdi=true |