Expression of CD14 Correlates With Lung Function Impairment in Pulmonary Sarcoidosis

CD14 expression on alveolar macrophages (AM) was studied in patients with sarcoidosis using immunocytochemistry and cytometric analysis. Compared with healthy control donors, patients had elevated percentages of CD14-positive AM (22 percent vs 34 percent), and the antigen density was threefold highe...

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Veröffentlicht in:	Chest 1994-02, Vol.105 (2), p.349-354
Hauptverfasser:	Pforte, Almuth, Schiessler, Alexander, Gais, Peter, Beer, Barbara, Ehlers, Monika, Schütt, Christine, Löms Ziegler-Heitbrock, Hans Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD - analysis Antigens, CD - blood Antigens, CD - drug effects Antigens, CD - genetics Antigens, Differentiation, Myelomonocytic - analysis Antigens, Differentiation, Myelomonocytic - blood Antigens, Differentiation, Myelomonocytic - drug effects Antigens, Differentiation, Myelomonocytic - genetics Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Cell Count Female Gene Expression Glucocorticoids - therapeutic use Humans Immunohistochemistry Lipopolysaccharide Receptors Lung - immunology Lung - physiopathology Lung Diseases - immunology Lung Diseases - physiopathology Macrophages, Alveolar - immunology Male Medical sciences Middle Aged Oxygen - blood Pulmonary Diffusing Capacity - drug effects Pulmonary Diffusing Capacity - physiology Sarcoidosis - immunology Sarcoidosis - physiopathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Staining and Labeling Vital Capacity - drug effects Vital Capacity - physiology
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