Murine epidermal Langerhans cells and splenic dendritic cells present tumor‐associated antigens to primed T cells
We examined the ability of epidermal Langerhans cells and splenic dendritic cells to present tumor‐associated antigens (Ag) to immune T cells. Methylcholanthrene (MCA)‐induced subcutaneous fibrosarcomas derived from C57BL/6 mice were used as tumor models. Our data demonstrate that both murine Langer...
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| Veröffentlicht in: | European journal of immunology 1994-02, Vol.24 (2), p.315-319 |
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| container_title | European journal of immunology |
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| creator | Cohen, Philip J. Cohen, Peter A. Rosenberg, Steven A. Mulé, James J. Katz, Stephen I. |
| description | We examined the ability of epidermal Langerhans cells and splenic dendritic cells to present tumor‐associated antigens (Ag) to immune T cells. Methylcholanthrene (MCA)‐induced subcutaneous fibrosarcomas derived from C57BL/6 mice were used as tumor models. Our data demonstrate that both murine Langerhans cells and splenic dendritic cells have the capacity to present tumor‐associated Ag to primed T cells. We found that variously treated tumor preparations (irradiated viable tumor cells, irradiated frozen‐stored tumor cells, mitomycin C‐treated viable tumor cells, and snap freeze‐thawed tumor cell lysates) can be utilized for tumor Ag‐pulsing. Primed CD4+ T cells demonstrated in vitro specificity towards their respective tumors and did not cross‐react to other syngeneic MCA‐induced or non‐MCA‐induced tumors. The T cell proliferative response critically depended on the presence of immune CD4+ T cells. We discuss the implications of these findings for the adoptive immunotherapy of cancer using immune CD4+ T cells. |
| doi_str_mv | 10.1002/eji.1830240206 |
| format | Article |
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Methylcholanthrene (MCA)‐induced subcutaneous fibrosarcomas derived from C57BL/6 mice were used as tumor models. Our data demonstrate that both murine Langerhans cells and splenic dendritic cells have the capacity to present tumor‐associated Ag to primed T cells. We found that variously treated tumor preparations (irradiated viable tumor cells, irradiated frozen‐stored tumor cells, mitomycin C‐treated viable tumor cells, and snap freeze‐thawed tumor cell lysates) can be utilized for tumor Ag‐pulsing. Primed CD4+ T cells demonstrated in vitro specificity towards their respective tumors and did not cross‐react to other syngeneic MCA‐induced or non‐MCA‐induced tumors. The T cell proliferative response critically depended on the presence of immune CD4+ T cells. We discuss the implications of these findings for the adoptive immunotherapy of cancer using immune CD4+ T cells.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830240206</identifier><identifier>PMID: 7905414</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Animals ; Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation ; Antigen-Presenting Cells - immunology ; Antigens, Neoplasm - immunology ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Dendritic cells ; Dendritic Cells - immunology ; Epidermis - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunologic Memory ; Langerhans cells ; Langerhans Cells - immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Molecular immunology ; Neoplasms, Experimental - immunology ; Spleen - immunology ; Tumor immunity ; Tumor‐associated antigens</subject><ispartof>European journal of immunology, 1994-02, Vol.24 (2), p.315-319</ispartof><rights>Copyright © 1994 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4006-75cff79e3a4d6e80ee72fb4353b38b1002f533fdf09cdb9fc95c2e1905c030403</citedby><cites>FETCH-LOGICAL-c4006-75cff79e3a4d6e80ee72fb4353b38b1002f533fdf09cdb9fc95c2e1905c030403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830240206$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830240206$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3934936$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7905414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Philip J.</creatorcontrib><creatorcontrib>Cohen, Peter A.</creatorcontrib><creatorcontrib>Rosenberg, Steven A.</creatorcontrib><creatorcontrib>Mulé, James J.</creatorcontrib><creatorcontrib>Katz, Stephen I.</creatorcontrib><title>Murine epidermal Langerhans cells and splenic dendritic cells present tumor‐associated antigens to primed T cells</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>We examined the ability of epidermal Langerhans cells and splenic dendritic cells to present tumor‐associated antigens (Ag) to immune T cells. Methylcholanthrene (MCA)‐induced subcutaneous fibrosarcomas derived from C57BL/6 mice were used as tumor models. Our data demonstrate that both murine Langerhans cells and splenic dendritic cells have the capacity to present tumor‐associated Ag to primed T cells. We found that variously treated tumor preparations (irradiated viable tumor cells, irradiated frozen‐stored tumor cells, mitomycin C‐treated viable tumor cells, and snap freeze‐thawed tumor cell lysates) can be utilized for tumor Ag‐pulsing. Primed CD4+ T cells demonstrated in vitro specificity towards their respective tumors and did not cross‐react to other syngeneic MCA‐induced or non‐MCA‐induced tumors. The T cell proliferative response critically depended on the presence of immune CD4+ T cells. We discuss the implications of these findings for the adoptive immunotherapy of cancer using immune CD4+ T cells.</description><subject>Animals</subject><subject>Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Epidermis - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunologic Memory</subject><subject>Langerhans cells</subject><subject>Langerhans Cells - immunology</subject><subject>Lymphocyte Activation</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular immunology</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Spleen - immunology</subject><subject>Tumor immunity</subject><subject>Tumor‐associated antigens</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbFu2zAQhokiheOkXbsF0BBkk3sUKckcA8NpU7jo4s4CRR1TBjLl8CQE3vIIecY8SSnISLuZCwned__9d8fYFw4LDpB9xUe34EsBmYQMig9szvOMp5JLfsbmAFymmVrCObsgegQAVeRqxmalgjwyc0Y_h-A8Jrh3DYadbpON9g8Y_mhPicG2pUT7JqF9i96ZpEHfBNfH1xTbByT0fdIPuy68vbxqos443WMT03r3gFGl7yLmdvFrO2V9Yh-tbgk_H-9L9vtuvV19Tze_vt2vbjepkQBFWubG2lKh0LIpcAmIZWZrKXJRi2U9Nm9zIWxjQZmmVtao3GTIY2cGBEgQl-xm0t2H7mlA6qudo9GB9tgNVJWFkGI8p0BeKMl5xiO4mEATOqKAtho70-FQcahGR1VcR_VvHTHh6qg81HEC7_hx_jF-fYxrMrq1QXvj6B0TSkglRhk1Yc-uxcOJotX6x_1_Fv4CnWalQg</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Cohen, Philip J.</creator><creator>Cohen, Peter A.</creator><creator>Rosenberg, Steven A.</creator><creator>Mulé, James J.</creator><creator>Katz, Stephen I.</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199402</creationdate><title>Murine epidermal Langerhans cells and splenic dendritic cells present tumor‐associated antigens to primed T cells</title><author>Cohen, Philip J. ; Cohen, Peter A. ; Rosenberg, Steven A. ; Mulé, James J. ; Katz, Stephen I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4006-75cff79e3a4d6e80ee72fb4353b38b1002f533fdf09cdb9fc95c2e1905c030403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Epidermis - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunologic Memory</topic><topic>Langerhans cells</topic><topic>Langerhans Cells - immunology</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular immunology</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Spleen - immunology</topic><topic>Tumor immunity</topic><topic>Tumor‐associated antigens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Philip J.</creatorcontrib><creatorcontrib>Cohen, Peter A.</creatorcontrib><creatorcontrib>Rosenberg, Steven A.</creatorcontrib><creatorcontrib>Mulé, James J.</creatorcontrib><creatorcontrib>Katz, Stephen I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Philip J.</au><au>Cohen, Peter A.</au><au>Rosenberg, Steven A.</au><au>Mulé, James J.</au><au>Katz, Stephen I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Murine epidermal Langerhans cells and splenic dendritic cells present tumor‐associated antigens to primed T cells</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1994-02</date><risdate>1994</risdate><volume>24</volume><issue>2</issue><spage>315</spage><epage>319</epage><pages>315-319</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>We examined the ability of epidermal Langerhans cells and splenic dendritic cells to present tumor‐associated antigens (Ag) to immune T cells. Methylcholanthrene (MCA)‐induced subcutaneous fibrosarcomas derived from C57BL/6 mice were used as tumor models. Our data demonstrate that both murine Langerhans cells and splenic dendritic cells have the capacity to present tumor‐associated Ag to primed T cells. We found that variously treated tumor preparations (irradiated viable tumor cells, irradiated frozen‐stored tumor cells, mitomycin C‐treated viable tumor cells, and snap freeze‐thawed tumor cell lysates) can be utilized for tumor Ag‐pulsing. Primed CD4+ T cells demonstrated in vitro specificity towards their respective tumors and did not cross‐react to other syngeneic MCA‐induced or non‐MCA‐induced tumors. The T cell proliferative response critically depended on the presence of immune CD4+ T cells. We discuss the implications of these findings for the adoptive immunotherapy of cancer using immune CD4+ T cells.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>7905414</pmid><doi>10.1002/eji.1830240206</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation Antigen-Presenting Cells - immunology Antigens, Neoplasm - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Dendritic cells Dendritic Cells - immunology Epidermis - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunologic Memory Langerhans cells Langerhans Cells - immunology Lymphocyte Activation Mice Mice, Inbred C57BL Molecular immunology Neoplasms, Experimental - immunology Spleen - immunology Tumor immunity Tumor‐associated antigens |
| title | Murine epidermal Langerhans cells and splenic dendritic cells present tumor‐associated antigens to primed T cells |
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