The relevance of flow-cytometric DNA content in the evaluation of lung cancer
Cells from a group of 185 patients suffering from malignant tumours (160 non-small-cell lung carcinoma, 13 small-cell lung carcinoma, and 12 non-epithelial tumours) and 6 with benign lung tumours were studied by flow cytometry in order to detect the prognostic value of DNA content. A total of 144 (9...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1994-02, Vol.120 (4), p.233-239 |
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| creator | SALVATI, F TEODORI, L TRINCA, M. L PASQUALI-LASAGNI, R GÖHDE, W |
| description | Cells from a group of 185 patients suffering from malignant tumours (160 non-small-cell lung carcinoma, 13 small-cell lung carcinoma, and 12 non-epithelial tumours) and 6 with benign lung tumours were studied by flow cytometry in order to detect the prognostic value of DNA content. A total of 144 (90%) non-small-cell lung carcinomas (NSCLC) and 8 (62%) small-cell lung carcinomas (SCLC) exhibited aneuploidy. Furthermore 52% (83 patients) NSCLC, 24% (3 patients) SCLC and 50% (6 patients) non-epithelial tumours demonstrated multiclonality. Benign cases showed diploid DNA content. For actuarial survival analysis using the Bergesson and Gage method and the Greenwood variance, 142 patients were selected. Statistical comparisons were made by the use of the t-test for unpaired data between fixed times. No correlation was observed between ploidy and stage, histological grading or treatment modality. A statistically significantly better survival was observed after 12, 18 and 24 months of follow-up for diploid and monoclonal (with the exclusion of hypo- and hypertetraploid) patients. Thus, flow-cytometric DNA analysis may be useful in prognostic assessment of human lung tumours. |
| doi_str_mv | 10.1007/BF01372562 |
| format | Article |
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L ; PASQUALI-LASAGNI, R ; GÖHDE, W</creator><creatorcontrib>SALVATI, F ; TEODORI, L ; TRINCA, M. L ; PASQUALI-LASAGNI, R ; GÖHDE, W</creatorcontrib><description>Cells from a group of 185 patients suffering from malignant tumours (160 non-small-cell lung carcinoma, 13 small-cell lung carcinoma, and 12 non-epithelial tumours) and 6 with benign lung tumours were studied by flow cytometry in order to detect the prognostic value of DNA content. A total of 144 (90%) non-small-cell lung carcinomas (NSCLC) and 8 (62%) small-cell lung carcinomas (SCLC) exhibited aneuploidy. Furthermore 52% (83 patients) NSCLC, 24% (3 patients) SCLC and 50% (6 patients) non-epithelial tumours demonstrated multiclonality. Benign cases showed diploid DNA content. For actuarial survival analysis using the Bergesson and Gage method and the Greenwood variance, 142 patients were selected. Statistical comparisons were made by the use of the t-test for unpaired data between fixed times. No correlation was observed between ploidy and stage, histological grading or treatment modality. A statistically significantly better survival was observed after 12, 18 and 24 months of follow-up for diploid and monoclonal (with the exclusion of hypo- and hypertetraploid) patients. 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L</creatorcontrib><creatorcontrib>PASQUALI-LASAGNI, R</creatorcontrib><creatorcontrib>GÖHDE, W</creatorcontrib><title>The relevance of flow-cytometric DNA content in the evaluation of lung cancer</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>Cells from a group of 185 patients suffering from malignant tumours (160 non-small-cell lung carcinoma, 13 small-cell lung carcinoma, and 12 non-epithelial tumours) and 6 with benign lung tumours were studied by flow cytometry in order to detect the prognostic value of DNA content. A total of 144 (90%) non-small-cell lung carcinomas (NSCLC) and 8 (62%) small-cell lung carcinomas (SCLC) exhibited aneuploidy. Furthermore 52% (83 patients) NSCLC, 24% (3 patients) SCLC and 50% (6 patients) non-epithelial tumours demonstrated multiclonality. Benign cases showed diploid DNA content. For actuarial survival analysis using the Bergesson and Gage method and the Greenwood variance, 142 patients were selected. Statistical comparisons were made by the use of the t-test for unpaired data between fixed times. No correlation was observed between ploidy and stage, histological grading or treatment modality. A statistically significantly better survival was observed after 12, 18 and 24 months of follow-up for diploid and monoclonal (with the exclusion of hypo- and hypertetraploid) patients. Thus, flow-cytometric DNA analysis may be useful in prognostic assessment of human lung tumours.</description><subject>Adult</subject><subject>Aged</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Carcinoma, Small Cell - mortality</subject><subject>Diploidy</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Neoplasm - genetics</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5iAchurPfPdZqVah6qeew2exqJB91d6P035vSUE_DMM_7wjwInQO-AYzl7d0CA5WEC3KAxsAoSYFSfojGGCSknIA4RichfOF-55KM0EgRpYSUY_Sy-rSJt5X90Y2xSesSV7W_qdnEtrbRlya5f50lpm2ibWJSNkns-R6uOh3LttkGqq75SMw27k_RkdNVsGfDnKD3xcNq_pQu3x6f57NlaihATLXFhTPCEU1BSgGEU6XN1DiVG82UJJrbXOVMCGkZm4KmjFluXCEVFJIDnaCrXe_at9-dDTGry2BsVenGtl3IpKCMsN7EBF3vQOPbELx12dqXtfabDHC2dZf9u-vhi6G1y2tb7NFBVn-_HO46GF053_9chj1GlSCAOf0Ddzd03A</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>SALVATI, F</creator><creator>TEODORI, L</creator><creator>TRINCA, M. 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L ; PASQUALI-LASAGNI, R ; GÖHDE, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-ae0dfc6f2a3177612538ac9cf8bca4872a5eb8b4667e4491a344e5cfd781d7513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Carcinoma, Small Cell - mortality</topic><topic>Diploidy</topic><topic>DNA, Neoplasm - analysis</topic><topic>DNA, Neoplasm - genetics</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SALVATI, F</creatorcontrib><creatorcontrib>TEODORI, L</creatorcontrib><creatorcontrib>TRINCA, M. L</creatorcontrib><creatorcontrib>PASQUALI-LASAGNI, R</creatorcontrib><creatorcontrib>GÖHDE, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALVATI, F</au><au>TEODORI, L</au><au>TRINCA, M. L</au><au>PASQUALI-LASAGNI, R</au><au>GÖHDE, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relevance of flow-cytometric DNA content in the evaluation of lung cancer</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>120</volume><issue>4</issue><spage>233</spage><epage>239</epage><pages>233-239</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Cells from a group of 185 patients suffering from malignant tumours (160 non-small-cell lung carcinoma, 13 small-cell lung carcinoma, and 12 non-epithelial tumours) and 6 with benign lung tumours were studied by flow cytometry in order to detect the prognostic value of DNA content. A total of 144 (90%) non-small-cell lung carcinomas (NSCLC) and 8 (62%) small-cell lung carcinomas (SCLC) exhibited aneuploidy. Furthermore 52% (83 patients) NSCLC, 24% (3 patients) SCLC and 50% (6 patients) non-epithelial tumours demonstrated multiclonality. Benign cases showed diploid DNA content. For actuarial survival analysis using the Bergesson and Gage method and the Greenwood variance, 142 patients were selected. Statistical comparisons were made by the use of the t-test for unpaired data between fixed times. No correlation was observed between ploidy and stage, histological grading or treatment modality. A statistically significantly better survival was observed after 12, 18 and 24 months of follow-up for diploid and monoclonal (with the exclusion of hypo- and hypertetraploid) patients. Thus, flow-cytometric DNA analysis may be useful in prognostic assessment of human lung tumours.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8288677</pmid><doi>10.1007/BF01372562</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aneuploidy Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Small Cell - genetics Carcinoma, Small Cell - mortality Diploidy DNA, Neoplasm - analysis DNA, Neoplasm - genetics Evaluation Studies as Topic Female Flow Cytometry Humans Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical sciences Middle Aged Pneumology Prognosis Prospective Studies Tumors of the respiratory system and mediastinum |
| title | The relevance of flow-cytometric DNA content in the evaluation of lung cancer |
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