Genetic analysis of immune dysfunction in non‐obese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bcl‐2 gene correlates with increased resistance of NOD T cells to apoptosis induction

The non‐obese diábetic (NOD) mouse strain provides a remarkable model for investigating the mechanisms of autoimmunity. Independent genetic analyses of this model have previously shown that chromosome 1‐linked loci were involved in the control of periinsulitis and sialitis on the one hand and of ins...

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Veröffentlicht in:	European journal of immunology 1994-02, Vol.24 (2), p.380-384
Hauptverfasser:	Garchon, Henri‐Jean, Luan, Jian‐Jian, Eloy, Laure, Bédossa, Pierre, Bach, Jean‐François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl‐2 gene Biological and medical sciences Candidate gene Chromosome Mapping Experimental and animal immunopathology. Animal models Genetic Linkage Genetic Markers Immunoglobulin G - blood Immunopathology Interleukin-2 - pharmacology Lymphocyte Activation Medical sciences Mice Mice, Inbred C57BL Mice, Inbred NOD - genetics Mice, Inbred NOD - immunology NOD mice Oncogenes Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 T-Lymphocytes - cytology T-Lymphocytes - immunology
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