HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to establish the primary HL...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1994-01, Vol.106 (1), p.160-167 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Mehal, Wajahat Z. Lo, Y.-M. Dennis Wordsworth, B. Paul Neuberger, James M. Hubscher, Stefan C. Fleming, Kenneth A. Chapman, Roger W. |
| description | Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to establish the primary HLA associations with PSC and to assess the ability of HLA alleles to mark for disease progression.
By applying molecular techniques to archival tissue, we have genotyped 83 PSC patients from two populations and 131 controls for the alleles HLA DR2, DR3, DR4, DRw12, DR52a, and Dw2.
HLA DR3, DR52a, DR2, and Dw2 were all significantly increased in PSC, with the relative risk for DR52a and Dw2 being greater than for DR3 and DR2, respectively. HLA DR4 was significantly decreased, but this may be artifactual to the DR3, DR2 increase. HLA DR4 and not DR52a marks for rapid disease progression in both our PSC populations.
HLA DR52a and Dw2 are the best candidate alleles for providing the known HLA association with PSC. HLA DR4 and not DR52a marks for rapid disease progression in our two PSC populations. |
| doi_str_mv | 10.1016/S0016-5085(94)95085-7 |
| format | Article |
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By applying molecular techniques to archival tissue, we have genotyped 83 PSC patients from two populations and 131 controls for the alleles HLA DR2, DR3, DR4, DRw12, DR52a, and Dw2.
HLA DR3, DR52a, DR2, and Dw2 were all significantly increased in PSC, with the relative risk for DR52a and Dw2 being greater than for DR3 and DR2, respectively. HLA DR4 was significantly decreased, but this may be artifactual to the DR3, DR2 increase. HLA DR4 and not DR52a marks for rapid disease progression in both our PSC populations.
HLA DR52a and Dw2 are the best candidate alleles for providing the known HLA association with PSC. HLA DR4 and not DR52a marks for rapid disease progression in our two PSC populations.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/S0016-5085(94)95085-7</identifier><identifier>PMID: 8276178</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Antigens, Differentiation - analysis ; Autoimmune Diseases - genetics ; Autoimmune Diseases - immunology ; Autoimmune Diseases - physiopathology ; Base Sequence ; Biological and medical sciences ; Cholangitis - genetics ; Cholangitis - immunology ; Cholangitis - physiopathology ; Chromosome Mapping ; Chronic Disease ; Colitis, Ulcerative - genetics ; Colitis, Ulcerative - immunology ; Colitis, Ulcerative - physiopathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Hepatitis - genetics ; Hepatitis - immunology ; Hepatitis - physiopathology ; HLA-DR4 Antigen - analysis ; HLA-DR4 Antigen - genetics ; Humans ; Leucine ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Oligonucleotide Probes - genetics ; Other diseases. Semiology ; Polymerase Chain Reaction ; Reference Values</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1994-01, Vol.106 (1), p.160-167</ispartof><rights>1994 American Gastroenterological Association</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-54d31a45bbd15496961882943a776fea1f11b6a171512328323b859554f4a29d3</citedby><cites>FETCH-LOGICAL-c436t-54d31a45bbd15496961882943a776fea1f11b6a171512328323b859554f4a29d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0016-5085(94)95085-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3918524$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8276178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehal, Wajahat Z.</creatorcontrib><creatorcontrib>Lo, Y.-M. Dennis</creatorcontrib><creatorcontrib>Wordsworth, B. Paul</creatorcontrib><creatorcontrib>Neuberger, James M.</creatorcontrib><creatorcontrib>Hubscher, Stefan C.</creatorcontrib><creatorcontrib>Fleming, Kenneth A.</creatorcontrib><creatorcontrib>Chapman, Roger W.</creatorcontrib><title>HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to establish the primary HLA associations with PSC and to assess the ability of HLA alleles to mark for disease progression.
By applying molecular techniques to archival tissue, we have genotyped 83 PSC patients from two populations and 131 controls for the alleles HLA DR2, DR3, DR4, DRw12, DR52a, and Dw2.
HLA DR3, DR52a, DR2, and Dw2 were all significantly increased in PSC, with the relative risk for DR52a and Dw2 being greater than for DR3 and DR2, respectively. HLA DR4 was significantly decreased, but this may be artifactual to the DR3, DR2 increase. HLA DR4 and not DR52a marks for rapid disease progression in both our PSC populations.
HLA DR52a and Dw2 are the best candidate alleles for providing the known HLA association with PSC. HLA DR4 and not DR52a marks for rapid disease progression in our two PSC populations.</description><subject>Amino Acid Sequence</subject><subject>Antigens, Differentiation - analysis</subject><subject>Autoimmune Diseases - genetics</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - physiopathology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cholangitis - genetics</subject><subject>Cholangitis - immunology</subject><subject>Cholangitis - physiopathology</subject><subject>Chromosome Mapping</subject><subject>Chronic Disease</subject><subject>Colitis, Ulcerative - genetics</subject><subject>Colitis, Ulcerative - immunology</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Hepatitis - genetics</subject><subject>Hepatitis - immunology</subject><subject>Hepatitis - physiopathology</subject><subject>HLA-DR4 Antigen - analysis</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>Humans</subject><subject>Leucine</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Probes - genetics</subject><subject>Other diseases. Semiology</subject><subject>Polymerase Chain Reaction</subject><subject>Reference Values</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qaFkoPwHJh6qCQyDjj8Q-IUQ_qLQSUilny3EmW9NsAp5dJP59vbvRXnvxh-aZ8euHsXMor6CE6vqxzGuhS6MvrLq020NRf2Bz0MIUuSY-svkBOWYnRM9lWVppYMZmRtQV1GbOHu8Xt_zrL8Ujcc9XPv3FxLsx8eRfYsvbSOgJ-UsalwmJ4jjwOORrzOg7p9BjGikOSx7-jL0flnEd6RM76nxPeDbtp-zp-7ffd_fF4uHHz7vbRRGUrNaFVq0Er3TTtKCVrWwFxgirpK_rqkMPHUBTeahBg5DCSCEbo63WqlNe2Faesi_7uTnd6wZp7VaRAvY5B44bcnUlpc0iMqj3YMhhKWHnpg84KN1WptvJdFtTziq3k-nq3Hc-PbBpVtgeuiZ7uf55qnsKvu-SH0KkAyYtGC1Uxm72GGYZbxGToxBxCNjGhGHt2jH-J8g_JG2Opg</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>Mehal, Wajahat Z.</creator><creator>Lo, Y.-M. Dennis</creator><creator>Wordsworth, B. Paul</creator><creator>Neuberger, James M.</creator><creator>Hubscher, Stefan C.</creator><creator>Fleming, Kenneth A.</creator><creator>Chapman, Roger W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199401</creationdate><title>HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis</title><author>Mehal, Wajahat Z. ; Lo, Y.-M. Dennis ; Wordsworth, B. Paul ; Neuberger, James M. ; Hubscher, Stefan C. ; Fleming, Kenneth A. ; Chapman, Roger W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-54d31a45bbd15496961882943a776fea1f11b6a171512328323b859554f4a29d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Antigens, Differentiation - analysis</topic><topic>Autoimmune Diseases - genetics</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - physiopathology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cholangitis - genetics</topic><topic>Cholangitis - immunology</topic><topic>Cholangitis - physiopathology</topic><topic>Chromosome Mapping</topic><topic>Chronic Disease</topic><topic>Colitis, Ulcerative - genetics</topic><topic>Colitis, Ulcerative - immunology</topic><topic>Colitis, Ulcerative - physiopathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genotype</topic><topic>Hepatitis - genetics</topic><topic>Hepatitis - immunology</topic><topic>Hepatitis - physiopathology</topic><topic>HLA-DR4 Antigen - analysis</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>Humans</topic><topic>Leucine</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotide Probes - genetics</topic><topic>Other diseases. Semiology</topic><topic>Polymerase Chain Reaction</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehal, Wajahat Z.</creatorcontrib><creatorcontrib>Lo, Y.-M. Dennis</creatorcontrib><creatorcontrib>Wordsworth, B. Paul</creatorcontrib><creatorcontrib>Neuberger, James M.</creatorcontrib><creatorcontrib>Hubscher, Stefan C.</creatorcontrib><creatorcontrib>Fleming, Kenneth A.</creatorcontrib><creatorcontrib>Chapman, Roger W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehal, Wajahat Z.</au><au>Lo, Y.-M. Dennis</au><au>Wordsworth, B. Paul</au><au>Neuberger, James M.</au><au>Hubscher, Stefan C.</au><au>Fleming, Kenneth A.</au><au>Chapman, Roger W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1994-01</date><risdate>1994</risdate><volume>106</volume><issue>1</issue><spage>160</spage><epage>167</epage><pages>160-167</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to establish the primary HLA associations with PSC and to assess the ability of HLA alleles to mark for disease progression.
By applying molecular techniques to archival tissue, we have genotyped 83 PSC patients from two populations and 131 controls for the alleles HLA DR2, DR3, DR4, DRw12, DR52a, and Dw2.
HLA DR3, DR52a, DR2, and Dw2 were all significantly increased in PSC, with the relative risk for DR52a and Dw2 being greater than for DR3 and DR2, respectively. HLA DR4 was significantly decreased, but this may be artifactual to the DR3, DR2 increase. HLA DR4 and not DR52a marks for rapid disease progression in both our PSC populations.
HLA DR52a and Dw2 are the best candidate alleles for providing the known HLA association with PSC. HLA DR4 and not DR52a marks for rapid disease progression in our two PSC populations.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8276178</pmid><doi>10.1016/S0016-5085(94)95085-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastroenterology (New York, N.Y. 1943), 1994-01, Vol.106 (1), p.160-167 |
| issn | 0016-5085 1528-0012 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Antigens, Differentiation - analysis Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - physiopathology Base Sequence Biological and medical sciences Cholangitis - genetics Cholangitis - immunology Cholangitis - physiopathology Chromosome Mapping Chronic Disease Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - physiopathology Female Gastroenterology. Liver. Pancreas. Abdomen Genotype Hepatitis - genetics Hepatitis - immunology Hepatitis - physiopathology HLA-DR4 Antigen - analysis HLA-DR4 Antigen - genetics Humans Leucine Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Molecular Sequence Data Oligonucleotide Probes - genetics Other diseases. Semiology Polymerase Chain Reaction Reference Values |
| title | HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis |
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