Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin

Thiazole-4-carboxamide adenine dinucleotide (TAD) is the active anabolite of the antitumor drug tiazofurin. Beta-methylene TAD (beta-TAD) is a phosphodiesterase-resistant analogue of TAD, active in tiazofurin-resistant cells. Beta-methylene SAD (beta-SAD) is the active selenium derivative of beta-TA...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 1994-01, Vol.33 (1), p.23-32
Hauptverfasser:	Li, H, Hallows, W. A, Punzi, J. S, Marquez, V. E, Carrell, H. L, Pankiewicz, K. W, Watanabe, K. A, Goldstein, B. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - chemistry Adenosine Diphosphate - metabolism Alcohol Dehydrogenase - chemistry Alcohol Dehydrogenase - metabolism Amino Acid Sequence Animals Antineoplastic Agents Binding Sites Biological and medical sciences Crystallography, X-Ray - methods General aspects Horses Ligands Liver - enzymology Medical sciences Models, Molecular Molecular Structure Organoselenium Compounds - chemistry Organoselenium Compounds - metabolism Pharmacology. Drug treatments Protein Conformation Ribavirin - analogs & derivatives Thiazoles - chemistry Thiazoles - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!