A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

Acute promyelocytic leukemia (APL) is associated with a t(15; 17) translocation that creates the promyelocyte-retinoic acid receptor α ( PML-RARα) fusion gene. Immunohistochemistry demonstrates that PML is a part of a novel macromolecular organelle (including at least three other nuclear proteins) r...

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Veröffentlicht in:	Cell 1994-01, Vol.76 (2), p.333-343
Hauptverfasser:	Dyck, Jacqueline A., Maul, Gerd G., Miller, Wilson H., Chen, J.Don, Kakizuka, Akira, Evans, Ronald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Nucleus - ultrastructure Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Fluorescent Antibody Technique Hematologic and hematopoietic diseases Humans Leukemia, Promyelocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Macromolecular Substances Medical sciences Neoplasm Proteins Nuclear Proteins - metabolism Oncogenes Promyelocytic Leukemia Protein Receptors, Retinoic Acid - immunology Receptors, Retinoic Acid - metabolism Transcription Factors - immunology Transcription Factors - metabolism Translocation, Genetic Tretinoin - pharmacology Tumor Suppressor Proteins
Online-Zugang:	Volltext
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