3-Methyleneoctanoyl-CoA and 3-methyl-trans-2-octenoyl-CoA: two new mechanism-based inhibitors of medium chain acyl-CoA dehydrogenase from pig kidney

The medium chain acyl-CoA dehydrogenase catalyzes the FAD-dependent oxidation of a variety of acyl-CoA substrates to the corresponding trans-2-enoyl-CoA thioesters. This work identifies 3-methyleneoctanoyl-CoA and 3-methyl-trans-2-octenoyl-CoA as representatives of a new class of mechanism-based inh...

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Veröffentlicht in:	Biochemistry (Easton) 1994-01, Vol.33 (3), p.788-797
Hauptverfasser:	Cummings, J G, Thorpe, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemical synthesis Acyl Coenzyme A - metabolism Acyl Coenzyme A - pharmacology Acyl-CoA Dehydrogenase Acyl-CoA Dehydrogenases - antagonists & inhibitors Aerobiosis Anaerobiosis Animals Flavins - metabolism Kidney - enzymology Models, Chemical Oxidation-Reduction Spectrophotometry Swine
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