How quickly can GABAA receptors open ?

We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concent...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1994, Vol.12 (1), p.61-71
Hauptverfasser:	MACONOCHIE, D. J, ZEMPEL, J. M, STEINBACH, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum - physiology Electrophysiology - methods Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - pharmacology Kinetics Membrane Potentials - drug effects Membrane Potentials - physiology Models, Neurological Neurons - physiology Purkinje Cells - physiology Rats Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Synapses - drug effects Synapses - physiology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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