Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy
We have used chemical sympathectomy with 6-hydroxydopamine (6-OHDA) in adult mice to study the role of the sympathetic nervous system (SNS) in regulating cellular proliferation and migration in lymphoid organs. Following sympathectomy, an increase in inguinal and axillary lymph node (LN) weight and...
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| Veröffentlicht in: | Journal of neuroimmunology 1994, Vol.49 (1), p.67-75 |
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| creator | Madden, Kelley S. Felten, Suzanne Y. Felten, David L. Hardy, Cheryl A. Livnat, Shmuel |
| description | We have used chemical sympathectomy with 6-hydroxydopamine (6-OHDA) in adult mice to study the role of the sympathetic nervous system (SNS) in regulating cellular proliferation and migration in lymphoid organs. Following sympathectomy, an increase in inguinal and axillary lymph node (LN) weight and cellularity was observed. The increased parallel increased cellular proliferation in vivo, as measured by uptake of [
125I]deoxyuridine (
125IUdR). Transient increases in cellular proliferation also were observed in spleen and bone marrow following sympathectomy. Administration of desipramine prior to 6-OHDA to prevent sympathectomy resulted in control levels of proliferation. β-Adrenoceptor blockade just prior to or following 6-OHDA treatment did not alter the enhanced proliferation. Migration of normal
51Cr-labelled lymphocytes into inguinal and axillary LN was enhanced in sympathectomized recipeints. Conversely, cells from sympathectomized animals showed diminished migration to these LN upon transfer into intact recipients. These results demonstrate that depletion of NA innervation alters cellular proliferation and lymphocyte migration in primary and secondary lymphoid organs. |
| doi_str_mv | 10.1016/0165-5728(94)90182-1 |
| format | Article |
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125I]deoxyuridine (
125IUdR). Transient increases in cellular proliferation also were observed in spleen and bone marrow following sympathectomy. Administration of desipramine prior to 6-OHDA to prevent sympathectomy resulted in control levels of proliferation. β-Adrenoceptor blockade just prior to or following 6-OHDA treatment did not alter the enhanced proliferation. Migration of normal
51Cr-labelled lymphocytes into inguinal and axillary LN was enhanced in sympathectomized recipeints. Conversely, cells from sympathectomized animals showed diminished migration to these LN upon transfer into intact recipients. These results demonstrate that depletion of NA innervation alters cellular proliferation and lymphocyte migration in primary and secondary lymphoid organs.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(94)90182-1</identifier><identifier>PMID: 8294563</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cell Movement ; DNA - biosynthesis ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immune System - innervation ; Immunobiology ; In vivo proliferation ; Lymph Nodes - pathology ; Lymphocyte Activation ; Lymphocyte migration ; Lymphocytes - physiology ; Mice ; Mice, Inbred BALB C ; Modulation of the immune response (stimulation, suppression) ; Neural-immune interaction ; Norepinephrine - physiology ; Oxidopamine ; Sympathectomy ; Sympathectomy, Chemical ; Sympathetic Nervous System - physiology</subject><ispartof>Journal of neuroimmunology, 1994, Vol.49 (1), p.67-75</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-d5fd34f1635808cb6115dd086efad4ab34f7c19e69894a38c0871c20b1b107fb3</citedby><cites>FETCH-LOGICAL-c332t-d5fd34f1635808cb6115dd086efad4ab34f7c19e69894a38c0871c20b1b107fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-5728(94)90182-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,4014,27914,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3944027$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8294563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madden, Kelley S.</creatorcontrib><creatorcontrib>Felten, Suzanne Y.</creatorcontrib><creatorcontrib>Felten, David L.</creatorcontrib><creatorcontrib>Hardy, Cheryl A.</creatorcontrib><creatorcontrib>Livnat, Shmuel</creatorcontrib><title>Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>We have used chemical sympathectomy with 6-hydroxydopamine (6-OHDA) in adult mice to study the role of the sympathetic nervous system (SNS) in regulating cellular proliferation and migration in lymphoid organs. Following sympathectomy, an increase in inguinal and axillary lymph node (LN) weight and cellularity was observed. The increased parallel increased cellular proliferation in vivo, as measured by uptake of [
125I]deoxyuridine (
125IUdR). Transient increases in cellular proliferation also were observed in spleen and bone marrow following sympathectomy. Administration of desipramine prior to 6-OHDA to prevent sympathectomy resulted in control levels of proliferation. β-Adrenoceptor blockade just prior to or following 6-OHDA treatment did not alter the enhanced proliferation. Migration of normal
51Cr-labelled lymphocytes into inguinal and axillary LN was enhanced in sympathectomized recipeints. Conversely, cells from sympathectomized animals showed diminished migration to these LN upon transfer into intact recipients. These results demonstrate that depletion of NA innervation alters cellular proliferation and lymphocyte migration in primary and secondary lymphoid organs.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Movement</subject><subject>DNA - biosynthesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immune System - innervation</subject><subject>Immunobiology</subject><subject>In vivo proliferation</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte migration</subject><subject>Lymphocytes - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Neural-immune interaction</subject><subject>Norepinephrine - physiology</subject><subject>Oxidopamine</subject><subject>Sympathectomy</subject><subject>Sympathectomy, Chemical</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-r1DAUxYMoz_HpN1DIQkQXfeYmaZtsHsjDPwMPXKjrkCapE2maMWkH-kH8vmZsnaUuLiGc3z1czkHoOZAbINC8LVNXdUvFa8nfSAKCVvAA7UC0tBKcwkO0uyCP0ZOcfxACNePyCl0JKnndsB369WUJRz0d3OQNHl06xTnjvOTJBRyinQc9-Tji2OPCYB_CPLpNv8H7fZnRzuYvMxSzQzTL5PAxxcH3Lq37erQ4-O_bz4_45E8Rdws2Bxe80UPxXO8wUwzLU_So10N2z7b3Gn378P7r3afq_vPH_d27-8owRqfK1r1lvIeG1YII0zUAtbVENK7XluuuaK0B6RopJNdMGCJaMJR00AFp-45do1erb7n25-zypILPxg2DHl0JQrUNY60g9L8gNJI0LYgC8hU0KeacXK-OyQedFgVEnWtT507UuRMlufpTm4Ky9mLzn7vg7GVp66noLzdd55JWn_RofL5gTHJOaFuw2xVzJbSTd0ll491onPWpJKts9P--4zdAIbbq</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Madden, Kelley S.</creator><creator>Felten, Suzanne Y.</creator><creator>Felten, David L.</creator><creator>Hardy, Cheryl A.</creator><creator>Livnat, Shmuel</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy</title><author>Madden, Kelley S. ; Felten, Suzanne Y. ; Felten, David L. ; Hardy, Cheryl A. ; Livnat, Shmuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-d5fd34f1635808cb6115dd086efad4ab34f7c19e69894a38c0871c20b1b107fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Movement</topic><topic>DNA - biosynthesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immune System - innervation</topic><topic>Immunobiology</topic><topic>In vivo proliferation</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte migration</topic><topic>Lymphocytes - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Neural-immune interaction</topic><topic>Norepinephrine - physiology</topic><topic>Oxidopamine</topic><topic>Sympathectomy</topic><topic>Sympathectomy, Chemical</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madden, Kelley S.</creatorcontrib><creatorcontrib>Felten, Suzanne Y.</creatorcontrib><creatorcontrib>Felten, David L.</creatorcontrib><creatorcontrib>Hardy, Cheryl A.</creatorcontrib><creatorcontrib>Livnat, Shmuel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madden, Kelley S.</au><au>Felten, Suzanne Y.</au><au>Felten, David L.</au><au>Hardy, Cheryl A.</au><au>Livnat, Shmuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1994</date><risdate>1994</risdate><volume>49</volume><issue>1</issue><spage>67</spage><epage>75</epage><pages>67-75</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>We have used chemical sympathectomy with 6-hydroxydopamine (6-OHDA) in adult mice to study the role of the sympathetic nervous system (SNS) in regulating cellular proliferation and migration in lymphoid organs. Following sympathectomy, an increase in inguinal and axillary lymph node (LN) weight and cellularity was observed. The increased parallel increased cellular proliferation in vivo, as measured by uptake of [
125I]deoxyuridine (
125IUdR). Transient increases in cellular proliferation also were observed in spleen and bone marrow following sympathectomy. Administration of desipramine prior to 6-OHDA to prevent sympathectomy resulted in control levels of proliferation. β-Adrenoceptor blockade just prior to or following 6-OHDA treatment did not alter the enhanced proliferation. Migration of normal
51Cr-labelled lymphocytes into inguinal and axillary LN was enhanced in sympathectomized recipeints. Conversely, cells from sympathectomized animals showed diminished migration to these LN upon transfer into intact recipients. These results demonstrate that depletion of NA innervation alters cellular proliferation and lymphocyte migration in primary and secondary lymphoid organs.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8294563</pmid><doi>10.1016/0165-5728(94)90182-1</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 1994, Vol.49 (1), p.67-75 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Cell Movement DNA - biosynthesis Fundamental and applied biological sciences. Psychology Fundamental immunology Immune System - innervation Immunobiology In vivo proliferation Lymph Nodes - pathology Lymphocyte Activation Lymphocyte migration Lymphocytes - physiology Mice Mice, Inbred BALB C Modulation of the immune response (stimulation, suppression) Neural-immune interaction Norepinephrine - physiology Oxidopamine Sympathectomy Sympathectomy, Chemical Sympathetic Nervous System - physiology |
| title | Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy |
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