Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

Platelet-rich thrombi are resistant to lysis by tissue-type plasminogen activator (t-PA). Although platelet alpha-granules contain plasminogen activator inhibitor-1 (PAI-1), a fast-acting inhibitor of t-PA, the contribution of PAI-1 to the antifibrinolytic effect of platelets has remained a subject...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood 1994-01, Vol.83 (2), p.351-356
Hauptverfasser:	Fay, W P, Eitzman, D T, Shapiro, A D, Madison, E L, Ginsburg, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - physiology Fibrinolysis Humans Mutation Plasminogen Activator Inhibitor 1 - physiology Streptokinase - pharmacology Tissue Plasminogen Activator - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!