Estrogen receptor mutations in tamoxifen-resistant breast cancer

Clinical resistance to antiestrogens like tamoxifen is a major problem in the treatment of hormone-dependent breast cancers. Since the estrogen receptor plays a central role in mediating the effects of estrogens and antiestrogens, we hypothesized that mutations in the estrogen receptor could be one...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-01, Vol.54 (2), p.349-353
Hauptverfasser:	KARNIK, P. S, KULKARNI, S, XIAO-PU LIU, BUDD, G. T, BUKOWSKI, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antineoplastic agents Base Sequence Biological and medical sciences Breast Neoplasms - chemistry Breast Neoplasms - genetics DNA, Complementary - chemistry DNA, Neoplasm - chemistry Drug Resistance - genetics Female General aspects Humans Medical sciences Molecular Sequence Data Mutation - genetics Neoplasms, Hormone-Dependent - chemistry Neoplasms, Hormone-Dependent - genetics Pharmacology. Drug treatments Phenotype Receptors, Estrogen - genetics Tamoxifen Transcription, Genetic
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