Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions

alpha 2-Macroglobulin (alpha 2M) binds numerous cytokines; however, since binding affinities have not been determined, it is difficult to compare various alpha 2M-cytokine interactions or predict whether alpha 2M-cytokine complexes will form in the presence of other cytokine-binding macromolecules....

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Veröffentlicht in:	The Journal of biological chemistry 1994-01, Vol.269 (2), p.1533-1540
Hauptverfasser:	Crookston, K P, Webb, D J, Wolf, B B, Gonias, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Macroglobulins - chemistry Cross-Linking Reagents Cytokines - chemistry In Vitro Techniques Kinetics Methylamines Protein Binding Solutions Thermodynamics
Online-Zugang:	Volltext
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