Modulation of Renin-Angiotensin and Kallikrein Gene Expression in Experimental Hypertension
Previous studies have shown that chronic lowdose administration of 40 ng/min angiotensin II by osmotic minipump to uninephrectomized rats mimics the temporal hypertensive response and the circulating angiotensin II levels observed in two-kidney, one clip Goldblatt rats. Furthermore, renal tissue ang...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-01, Vol.23 (1 Suppl I), p.I-131-I-136 |
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| container_issue | 1 Suppl I |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | von Thun, Annette M El-Dahr, Samir S Vari, Richard C Navar, L Gabriel |
| description | Previous studies have shown that chronic lowdose administration of 40 ng/min angiotensin II by osmotic minipump to uninephrectomized rats mimics the temporal hypertensive response and the circulating angiotensin II levels observed in two-kidney, one clip Goldblatt rats. Furthermore, renal tissue angiotensin II contents were higher than the circulating angiotensin II levels, suggesting that circulating angiotensin II induces endogenous intrarenal angiotensin II production. The present study examined the molecular mechanisms by which intrarenal angiotensin II production is modulated in angiotensin H-induced and two-kidney Goldblatt hypertension. Two weeks after clipping, intrarenal renin mRNA levels were elevated threefold in the clipped kidney of Goldblatt rats but were markedly suppressed in the nonclipped kidneys of Goldblatt rats (28% of control values) and in the remaining kidney of uninephrectomized angiotensin II-infused rats (7% of control values). In contrast, there were sustained levels of angiotensinogen mRNA in the kidneys and livers of Goldblatt and angiotensin II-infused rats, indicating differential regulation of the genes of the renin-angiotensin system. Renal kallikrein gene expression was not altered in either of the hypertensive groups 14 days after the induction of hypertension, suggesting the absence of an enhanced counteracting kinin influence. |
| doi_str_mv | 10.1161/01.HYP.23.1_Suppl.I131 |
| format | Article |
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Furthermore, renal tissue angiotensin II contents were higher than the circulating angiotensin II levels, suggesting that circulating angiotensin II induces endogenous intrarenal angiotensin II production. The present study examined the molecular mechanisms by which intrarenal angiotensin II production is modulated in angiotensin H-induced and two-kidney Goldblatt hypertension. Two weeks after clipping, intrarenal renin mRNA levels were elevated threefold in the clipped kidney of Goldblatt rats but were markedly suppressed in the nonclipped kidneys of Goldblatt rats (28% of control values) and in the remaining kidney of uninephrectomized angiotensin II-infused rats (7% of control values). In contrast, there were sustained levels of angiotensinogen mRNA in the kidneys and livers of Goldblatt and angiotensin II-infused rats, indicating differential regulation of the genes of the renin-angiotensin system. Renal kallikrein gene expression was not altered in either of the hypertensive groups 14 days after the induction of hypertension, suggesting the absence of an enhanced counteracting kinin influence.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.23.1_Suppl.I131</identifier><identifier>PMID: 7506697</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Angiotensin II - biosynthesis ; Angiotensin II - blood ; Angiotensinogen - biosynthesis ; Animals ; Biological and medical sciences ; Blood Pressure ; Blotting, Northern ; Cardiology. Vascular system ; Gene Expression Regulation ; Heart ; Hypertension, Renovascular - metabolism ; Hypertension, Renovascular - physiopathology ; Kallikreins - biosynthesis ; Kidney - enzymology ; Male ; Medical sciences ; Myocarditis. Cardiomyopathies ; Rats ; Rats, Sprague-Dawley ; Renin - biosynthesis ; Renin - blood ; Renin-Angiotensin System ; RNA - isolation & purification ; RNA - metabolism ; RNA, Messenger - analysis ; RNA, Messenger - biosynthesis ; RNA, Messenger - metabolism</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1994-01, Vol.23 (1 Suppl I), p.I-131-I-136</ispartof><rights>1994 American Heart Association, Inc.</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jan 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4559-bccc250a6a60affbf47e993dd9245e4028c7dee2e57f921b99a0c592fd5635ba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,3685,4048,4049,23929,23930,25139,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3954885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7506697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>von Thun, Annette M</creatorcontrib><creatorcontrib>El-Dahr, Samir S</creatorcontrib><creatorcontrib>Vari, Richard C</creatorcontrib><creatorcontrib>Navar, L Gabriel</creatorcontrib><title>Modulation of Renin-Angiotensin and Kallikrein Gene Expression in Experimental Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Previous studies have shown that chronic lowdose administration of 40 ng/min angiotensin II by osmotic minipump to uninephrectomized rats mimics the temporal hypertensive response and the circulating angiotensin II levels observed in two-kidney, one clip Goldblatt rats. Furthermore, renal tissue angiotensin II contents were higher than the circulating angiotensin II levels, suggesting that circulating angiotensin II induces endogenous intrarenal angiotensin II production. The present study examined the molecular mechanisms by which intrarenal angiotensin II production is modulated in angiotensin H-induced and two-kidney Goldblatt hypertension. Two weeks after clipping, intrarenal renin mRNA levels were elevated threefold in the clipped kidney of Goldblatt rats but were markedly suppressed in the nonclipped kidneys of Goldblatt rats (28% of control values) and in the remaining kidney of uninephrectomized angiotensin II-infused rats (7% of control values). In contrast, there were sustained levels of angiotensinogen mRNA in the kidneys and livers of Goldblatt and angiotensin II-infused rats, indicating differential regulation of the genes of the renin-angiotensin system. Renal kallikrein gene expression was not altered in either of the hypertensive groups 14 days after the induction of hypertension, suggesting the absence of an enhanced counteracting kinin influence.</description><subject>Angiotensin II - biosynthesis</subject><subject>Angiotensin II - blood</subject><subject>Angiotensinogen - biosynthesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Blotting, Northern</subject><subject>Cardiology. Vascular system</subject><subject>Gene Expression Regulation</subject><subject>Heart</subject><subject>Hypertension, Renovascular - metabolism</subject><subject>Hypertension, Renovascular - physiopathology</subject><subject>Kallikreins - biosynthesis</subject><subject>Kidney - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renin - biosynthesis</subject><subject>Renin - blood</subject><subject>Renin-Angiotensin System</subject><subject>RNA - isolation & purification</subject><subject>RNA - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - metabolism</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVtv1DAQhS0EKkvhJ4AihHhL8PiW9WNVlW5FEYiLBOLBcpwJTeu1t3ai0n-Pl436gF-sM_OdkeeYkFdAGwAF7yg0m5-fG8YbMF_n3c43F8DhEVmBZKIWUvHHZEVBi1oD_HhKnuV8TSkIIdojctRKqpRuV-TXx9jP3k5jDFUcqi8YxlCfhN9jnDDkMVQ29NUH6_14k7DIcwxYnf3ZJcx57ymlojCNWwyT9dXmvoh_1hiekyeD9RlfLPcx-f7-7Nvppr78dH5xenJZOyGlrjvnHJPUKquoHYZuEC1qzfteMyFRULZ2bY_IULaDZtBpbamTmg19WVJ2lh-Tt4e5uxRvZ8yT2Y7Zofc2YJyzaRXnQLko4Ov_wOs4p1DeZhiVTLUt7CF1gFyKOScczK5sZ9O9AWr20RsKpkRvGDdL9GYffTG-XKbP3Rb7B9uSdem_Wfo2O-uHZIMb8wPGtRTrtSyYOGB30U-Y8o2f7zCZK7R-ujK0HMHUugatBYXyo3WpMM3_Ahsrnys</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>von Thun, Annette M</creator><creator>El-Dahr, Samir S</creator><creator>Vari, Richard C</creator><creator>Navar, L Gabriel</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199401</creationdate><title>Modulation of Renin-Angiotensin and Kallikrein Gene Expression in Experimental Hypertension</title><author>von Thun, Annette M ; El-Dahr, Samir S ; Vari, Richard C ; Navar, L Gabriel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4559-bccc250a6a60affbf47e993dd9245e4028c7dee2e57f921b99a0c592fd5635ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Angiotensin II - biosynthesis</topic><topic>Angiotensin II - blood</topic><topic>Angiotensinogen - biosynthesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Blotting, Northern</topic><topic>Cardiology. Vascular system</topic><topic>Gene Expression Regulation</topic><topic>Heart</topic><topic>Hypertension, Renovascular - metabolism</topic><topic>Hypertension, Renovascular - physiopathology</topic><topic>Kallikreins - biosynthesis</topic><topic>Kidney - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Renin - biosynthesis</topic><topic>Renin - blood</topic><topic>Renin-Angiotensin System</topic><topic>RNA - isolation & purification</topic><topic>RNA - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Thun, Annette M</creatorcontrib><creatorcontrib>El-Dahr, Samir S</creatorcontrib><creatorcontrib>Vari, Richard C</creatorcontrib><creatorcontrib>Navar, L Gabriel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>von Thun, Annette M</au><au>El-Dahr, Samir S</au><au>Vari, Richard C</au><au>Navar, L Gabriel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Renin-Angiotensin and Kallikrein Gene Expression in Experimental Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1994-01</date><risdate>1994</risdate><volume>23</volume><issue>1 Suppl I</issue><spage>I-131</spage><epage>I-136</epage><pages>I-131-I-136</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Previous studies have shown that chronic lowdose administration of 40 ng/min angiotensin II by osmotic minipump to uninephrectomized rats mimics the temporal hypertensive response and the circulating angiotensin II levels observed in two-kidney, one clip Goldblatt rats. Furthermore, renal tissue angiotensin II contents were higher than the circulating angiotensin II levels, suggesting that circulating angiotensin II induces endogenous intrarenal angiotensin II production. The present study examined the molecular mechanisms by which intrarenal angiotensin II production is modulated in angiotensin H-induced and two-kidney Goldblatt hypertension. Two weeks after clipping, intrarenal renin mRNA levels were elevated threefold in the clipped kidney of Goldblatt rats but were markedly suppressed in the nonclipped kidneys of Goldblatt rats (28% of control values) and in the remaining kidney of uninephrectomized angiotensin II-infused rats (7% of control values). In contrast, there were sustained levels of angiotensinogen mRNA in the kidneys and livers of Goldblatt and angiotensin II-infused rats, indicating differential regulation of the genes of the renin-angiotensin system. 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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Angiotensin II - biosynthesis Angiotensin II - blood Angiotensinogen - biosynthesis Animals Biological and medical sciences Blood Pressure Blotting, Northern Cardiology. Vascular system Gene Expression Regulation Heart Hypertension, Renovascular - metabolism Hypertension, Renovascular - physiopathology Kallikreins - biosynthesis Kidney - enzymology Male Medical sciences Myocarditis. Cardiomyopathies Rats Rats, Sprague-Dawley Renin - biosynthesis Renin - blood Renin-Angiotensin System RNA - isolation & purification RNA - metabolism RNA, Messenger - analysis RNA, Messenger - biosynthesis RNA, Messenger - metabolism |
| title | Modulation of Renin-Angiotensin and Kallikrein Gene Expression in Experimental Hypertension |
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