Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein
The effect of a nitric oxide (NO) donor GEA 3162 on the endothelial cell (EC)-mediated oxidation of low density lipoprotein (LDL) was studied. In comparison to LDL incubated with EC without GEA 3162, the presence of GEA 3162 inhibited LDL oxidation by EC, as indicated by the following findings. (a)...
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| Veröffentlicht in: | FEBS letters 1994-01, Vol.337 (2), p.179-183 |
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| creator | Malo-Ranta, Ulla Ylä-Herttuala, Seppo Metsä-Ketelä, Timo Jaakkola, Olli Moilanen, Eeva Vuorinen, Pauli Nikkari, Tapio |
| description | The effect of a nitric oxide (NO) donor GEA 3162 on the endothelial cell (EC)-mediated oxidation of low density lipoprotein (LDL) was studied. In comparison to LDL incubated with EC without GEA 3162, the presence of GEA 3162 inhibited LDL oxidation by EC, as indicated by the following findings. (a) The degradation rate of LDL in macrophages was reduced to control levels. (b) The electrophoretic mobility of LDL decreased in a dose-dependent manner, (c) The concentrations of thiobarbituric acid-reactive substances and hydroperoxide-derived hydroxy fatty acids were lower. (d) The breakdown of apolipoprotein B was reduced. The results indicate that GEA 3162 prevents EC-mediated oxidation of LDL. |
| doi_str_mv | 10.1016/0014-5793(94)80269-6 |
| format | Article |
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In comparison to LDL incubated with EC without GEA 3162, the presence of GEA 3162 inhibited LDL oxidation by EC, as indicated by the following findings. (a) The degradation rate of LDL in macrophages was reduced to control levels. (b) The electrophoretic mobility of LDL decreased in a dose-dependent manner, (c) The concentrations of thiobarbituric acid-reactive substances and hydroperoxide-derived hydroxy fatty acids were lower. (d) The breakdown of apolipoprotein B was reduced. The results indicate that GEA 3162 prevents EC-mediated oxidation of LDL.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(94)80269-6</identifier><identifier>PMID: 8287973</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Aorta ; Atherosclerosis ; Biological and medical sciences ; Cells, Cultured ; DMEM, Dulbecco's modified Eagle's medium ; EC, endothelial cells ; Electrophoresis, Polyacrylamide Gel ; Endothelial cell ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoblotting ; LDL, low density lipoprotein ; Lipoproteins, LDL - drug effects ; Lipoproteins, LDL - isolation & purification ; Lipoproteins, LDL - metabolism ; Lipoproteins, myelin ; LPDS, lipoprotein-deficient serum ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; MDA, malondialdehyde ; Mice ; Nitric oxide ; Nitric Oxide - pharmacology ; NO, nitric oxide ; O2 −, superoxide anion ; Oxidation-Reduction ; Oxidized low density lipoprotein ; Proteins ; Rats ; SDS-PAGE, SDS-polyacrylamide gel electrophoresis ; SIN-1 ; SIN-1,3-morpholinosydnonimine-hydrochloride ; TBARS, thiobarbituric acid-reactive substances ; Triazoles - pharmacology</subject><ispartof>FEBS letters, 1994-01, Vol.337 (2), p.179-183</ispartof><rights>1994</rights><rights>FEBS Letters 337 (1994) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5616-117866b493ae8646e3601379b3949c42b4d9b60601de80916beb3303421e10ce3</citedby><cites>FETCH-LOGICAL-c5616-117866b493ae8646e3601379b3949c42b4d9b60601de80916beb3303421e10ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(94)80269-6$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3902494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8287973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malo-Ranta, Ulla</creatorcontrib><creatorcontrib>Ylä-Herttuala, Seppo</creatorcontrib><creatorcontrib>Metsä-Ketelä, Timo</creatorcontrib><creatorcontrib>Jaakkola, Olli</creatorcontrib><creatorcontrib>Moilanen, Eeva</creatorcontrib><creatorcontrib>Vuorinen, Pauli</creatorcontrib><creatorcontrib>Nikkari, Tapio</creatorcontrib><title>Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The effect of a nitric oxide (NO) donor GEA 3162 on the endothelial cell (EC)-mediated oxidation of low density lipoprotein (LDL) was studied. In comparison to LDL incubated with EC without GEA 3162, the presence of GEA 3162 inhibited LDL oxidation by EC, as indicated by the following findings. (a) The degradation rate of LDL in macrophages was reduced to control levels. (b) The electrophoretic mobility of LDL decreased in a dose-dependent manner, (c) The concentrations of thiobarbituric acid-reactive substances and hydroperoxide-derived hydroxy fatty acids were lower. (d) The breakdown of apolipoprotein B was reduced. The results indicate that GEA 3162 prevents EC-mediated oxidation of LDL.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Aorta</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>DMEM, Dulbecco's modified Eagle's medium</subject><subject>EC, endothelial cells</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Endothelial cell</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>LDL, low density lipoprotein</subject><subject>Lipoproteins, LDL - drug effects</subject><subject>Lipoproteins, LDL - isolation & purification</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Lipoproteins, myelin</subject><subject>LPDS, lipoprotein-deficient serum</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>MDA, malondialdehyde</subject><subject>Mice</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>NO, nitric oxide</subject><subject>O2 −, superoxide anion</subject><subject>Oxidation-Reduction</subject><subject>Oxidized low density lipoprotein</subject><subject>Proteins</subject><subject>Rats</subject><subject>SDS-PAGE, SDS-polyacrylamide gel electrophoresis</subject><subject>SIN-1</subject><subject>SIN-1,3-morpholinosydnonimine-hydrochloride</subject><subject>TBARS, thiobarbituric acid-reactive substances</subject><subject>Triazoles - pharmacology</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGPFCEQhYnRrOPqP9CEgzF6aIWGpeFism5mVpONXvRMaKjJlumBERjX-ffSM5M5Gk-EV69eFR-EvOTsPWdcfWCMy-5qMOKtke8065Xp1COy4HoQnZBKPyaLs-UpeVbKT9bumpsLcqF7PZhBLIj_ijWjp-kPBqAhxZTp7fKaCq56ivEeR6yFQgyp3sOEbqIepqnbQEBXIRz6XMUUaVrTKT3QALFg3dMJt2mbUwWMz8mTtZsKvDidl-THavn95nN39-32y831XeevFFcd54NWapRGONBKKhCKcTGYURhpvOxHGcyoWBMDaGa4GmEUggnZc-DMg7gkb465be6vHZRqN1jmdV2EtCt2UM3Oe9mM8mj0OZWSYW23GTcu7y1ndmZrZ3B2BmeNtAe2VrW2V6f83dgAnJtOMFv99anuinfTOrvosZxtwrBemnn66mh7wAn2_zXarpaf-rkw60Ye1Hmfj8cgaFB_I2RbPEL07W8y-GpDwn8_6C-WtKb3</recordid><startdate>19940110</startdate><enddate>19940110</enddate><creator>Malo-Ranta, Ulla</creator><creator>Ylä-Herttuala, Seppo</creator><creator>Metsä-Ketelä, Timo</creator><creator>Jaakkola, Olli</creator><creator>Moilanen, Eeva</creator><creator>Vuorinen, Pauli</creator><creator>Nikkari, Tapio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940110</creationdate><title>Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein</title><author>Malo-Ranta, Ulla ; Ylä-Herttuala, Seppo ; Metsä-Ketelä, Timo ; Jaakkola, Olli ; Moilanen, Eeva ; Vuorinen, Pauli ; Nikkari, Tapio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5616-117866b493ae8646e3601379b3949c42b4d9b60601de80916beb3303421e10ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Aorta</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>DMEM, Dulbecco's modified Eagle's medium</topic><topic>EC, endothelial cells</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Endothelial cell</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>LDL, low density lipoprotein</topic><topic>Lipoproteins, LDL - drug effects</topic><topic>Lipoproteins, LDL - isolation & purification</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Lipoproteins, myelin</topic><topic>LPDS, lipoprotein-deficient serum</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>MDA, malondialdehyde</topic><topic>Mice</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>NO, nitric oxide</topic><topic>O2 −, superoxide anion</topic><topic>Oxidation-Reduction</topic><topic>Oxidized low density lipoprotein</topic><topic>Proteins</topic><topic>Rats</topic><topic>SDS-PAGE, SDS-polyacrylamide gel electrophoresis</topic><topic>SIN-1</topic><topic>SIN-1,3-morpholinosydnonimine-hydrochloride</topic><topic>TBARS, thiobarbituric acid-reactive substances</topic><topic>Triazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malo-Ranta, Ulla</creatorcontrib><creatorcontrib>Ylä-Herttuala, Seppo</creatorcontrib><creatorcontrib>Metsä-Ketelä, Timo</creatorcontrib><creatorcontrib>Jaakkola, Olli</creatorcontrib><creatorcontrib>Moilanen, Eeva</creatorcontrib><creatorcontrib>Vuorinen, Pauli</creatorcontrib><creatorcontrib>Nikkari, Tapio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malo-Ranta, Ulla</au><au>Ylä-Herttuala, Seppo</au><au>Metsä-Ketelä, Timo</au><au>Jaakkola, Olli</au><au>Moilanen, Eeva</au><au>Vuorinen, Pauli</au><au>Nikkari, Tapio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1994-01-10</date><risdate>1994</risdate><volume>337</volume><issue>2</issue><spage>179</spage><epage>183</epage><pages>179-183</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The effect of a nitric oxide (NO) donor GEA 3162 on the endothelial cell (EC)-mediated oxidation of low density lipoprotein (LDL) was studied. In comparison to LDL incubated with EC without GEA 3162, the presence of GEA 3162 inhibited LDL oxidation by EC, as indicated by the following findings. (a) The degradation rate of LDL in macrophages was reduced to control levels. (b) The electrophoretic mobility of LDL decreased in a dose-dependent manner, (c) The concentrations of thiobarbituric acid-reactive substances and hydroperoxide-derived hydroxy fatty acids were lower. (d) The breakdown of apolipoprotein B was reduced. The results indicate that GEA 3162 prevents EC-mediated oxidation of LDL.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8287973</pmid><doi>10.1016/0014-5793(94)80269-6</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1994-01, Vol.337 (2), p.179-183 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Analytical, structural and metabolic biochemistry Animals Aorta Atherosclerosis Biological and medical sciences Cells, Cultured DMEM, Dulbecco's modified Eagle's medium EC, endothelial cells Electrophoresis, Polyacrylamide Gel Endothelial cell Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Humans Immunoblotting LDL, low density lipoprotein Lipoproteins, LDL - drug effects Lipoproteins, LDL - isolation & purification Lipoproteins, LDL - metabolism Lipoproteins, myelin LPDS, lipoprotein-deficient serum Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism MDA, malondialdehyde Mice Nitric oxide Nitric Oxide - pharmacology NO, nitric oxide O2 −, superoxide anion Oxidation-Reduction Oxidized low density lipoprotein Proteins Rats SDS-PAGE, SDS-polyacrylamide gel electrophoresis SIN-1 SIN-1,3-morpholinosydnonimine-hydrochloride TBARS, thiobarbituric acid-reactive substances Triazoles - pharmacology |
| title | Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein |
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