Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis
Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi 1 . Weeks to months after the onset of disease, approximately 60 percent of untreated patients begin to have brief, intermittent attacks of arthritis that may recur for several years 2 . A small percentage of these patients hav...
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| Veröffentlicht in: | The New England journal of medicine 1994-01, Vol.330 (4), p.229-234 |
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| container_title | The New England journal of medicine |
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| creator | Nocton, James J Dressler, Frank Rutledge, Barbara J Rys, Paul N Persing, David H Steere, Allen C |
| description | Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi
1
. Weeks to months after the onset of disease, approximately 60 percent of untreated patients begin to have brief, intermittent attacks of arthritis that may recur for several years
2
. A small percentage of these patients have continuous arthritis for one year or longer, a condition we have termed “chronic Lyme arthritis”
2
,
3
. Eventually, both intermittent and chronic Lyme arthritis resolve, even in untreated patients
2
,
4
.
Lyme arthritis can usually be treated successfully with either a one-month course of doxycycline or amoxicillin or a two-week course of intravenous . . . |
| doi_str_mv | 10.1056/NEJM199401273300401 |
| format | Article |
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1
. Weeks to months after the onset of disease, approximately 60 percent of untreated patients begin to have brief, intermittent attacks of arthritis that may recur for several years
2
. A small percentage of these patients have continuous arthritis for one year or longer, a condition we have termed “chronic Lyme arthritis”
2
,
3
. Eventually, both intermittent and chronic Lyme arthritis resolve, even in untreated patients
2
,
4
.
Lyme arthritis can usually be treated successfully with either a one-month course of doxycycline or amoxicillin or a two-week course of intravenous . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199401273300401</identifier><identifier>PMID: 8272083</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Aged ; Arthritis, Infectious - diagnosis ; Arthritis, Infectious - microbiology ; Bacterial arthritis and osteitis ; Bacterial diseases ; Base Sequence ; Biological and medical sciences ; Borrelia burgdorferi ; Borrelia burgdorferi Group - genetics ; Borrelia burgdorferi Group - isolation & purification ; Child ; Child, Preschool ; Deoxyribonucleic acid ; DNA ; DNA Primers ; DNA Probes ; DNA, Bacterial - analysis ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Lyme disease ; Lyme Disease - diagnosis ; Lyme Disease - microbiology ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction ; Rheumatoid arthritis ; Synovial Fluid - microbiology</subject><ispartof>The New England journal of medicine, 1994-01, Vol.330 (4), p.229-234</ispartof><rights>Copyright © 1994 Massachusetts Medical Society. All rights reserved.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-45873f6c5fb27ec098f3d2f1065397a1882cf28866e204fc36cf8f0ab69368523</citedby><cites>FETCH-LOGICAL-c555t-45873f6c5fb27ec098f3d2f1065397a1882cf28866e204fc36cf8f0ab69368523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199401273300401$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199401273300401$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3910189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8272083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nocton, James J</creatorcontrib><creatorcontrib>Dressler, Frank</creatorcontrib><creatorcontrib>Rutledge, Barbara J</creatorcontrib><creatorcontrib>Rys, Paul N</creatorcontrib><creatorcontrib>Persing, David H</creatorcontrib><creatorcontrib>Steere, Allen C</creatorcontrib><title>Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi
1
. Weeks to months after the onset of disease, approximately 60 percent of untreated patients begin to have brief, intermittent attacks of arthritis that may recur for several years
2
. A small percentage of these patients have continuous arthritis for one year or longer, a condition we have termed “chronic Lyme arthritis”
2
,
3
. Eventually, both intermittent and chronic Lyme arthritis resolve, even in untreated patients
2
,
4
.
Lyme arthritis can usually be treated successfully with either a one-month course of doxycycline or amoxicillin or a two-week course of intravenous . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Infectious - diagnosis</subject><subject>Arthritis, Infectious - microbiology</subject><subject>Bacterial arthritis and osteitis</subject><subject>Bacterial diseases</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Borrelia burgdorferi</subject><subject>Borrelia burgdorferi Group - genetics</subject><subject>Borrelia burgdorferi Group - isolation & purification</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Primers</subject><subject>DNA Probes</subject><subject>DNA, Bacterial - analysis</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lyme disease</subject><subject>Lyme Disease - diagnosis</subject><subject>Lyme Disease - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Rheumatoid arthritis</subject><subject>Synovial Fluid - microbiology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkduKFDEQhoMo67j6BCIEEW-ktZJ0Tpfj7K4HxnXxcN2kM4mTobuzm6RX5u2NzLAXIlo3VVDfX0XVj9BTAq8JcPHm8vzjJ6J1C4RKxgBqcQ8tCGesaVsQ99ECgKqmlZo9RI9y3kEN0uoTdKKopKDYAt2eueJsCXHC0eO3MSU3BIP7Of3YxORdCvjscon7Pb6Kw350yWSHV1sTJvzFmYOw1l_3U7wNZsAXwxw22Kc44itTgptKxj9D2eJ1FeNlKtsUSsiP0QNvhuyeHPMp-n5x_m31vll_fvdhtVw3lnNempYrybyw3PdUOgtaebahnoDgTEtDlKLWU6WEcBRab5mwXnkwvdBMKE7ZKXp5mHud4s3scunGkK0bBjO5OOdOCka1bOV_QSKkAkahgs__AHdxTlM9oqO0rQ_WRFSIHSCbYs7J-e46hdGkfUeg--1d9xfvqurZcfTcj25zpzmaVfsvjn2TrRl8MpMN-Q5jmgBRumKvDtg45m5yu_GfS38B4Aqr2A</recordid><startdate>19940127</startdate><enddate>19940127</enddate><creator>Nocton, James J</creator><creator>Dressler, Frank</creator><creator>Rutledge, Barbara J</creator><creator>Rys, Paul N</creator><creator>Persing, David H</creator><creator>Steere, Allen C</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19940127</creationdate><title>Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis</title><author>Nocton, James J ; Dressler, Frank ; Rutledge, Barbara J ; Rys, Paul N ; Persing, David H ; Steere, Allen C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-45873f6c5fb27ec098f3d2f1065397a1882cf28866e204fc36cf8f0ab69368523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Infectious - diagnosis</topic><topic>Arthritis, Infectious - microbiology</topic><topic>Bacterial arthritis and osteitis</topic><topic>Bacterial diseases</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Borrelia burgdorferi</topic><topic>Borrelia burgdorferi Group - genetics</topic><topic>Borrelia burgdorferi Group - isolation & purification</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Primers</topic><topic>DNA Probes</topic><topic>DNA, Bacterial - analysis</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lyme disease</topic><topic>Lyme Disease - diagnosis</topic><topic>Lyme Disease - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Rheumatoid arthritis</topic><topic>Synovial Fluid - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nocton, James J</creatorcontrib><creatorcontrib>Dressler, Frank</creatorcontrib><creatorcontrib>Rutledge, Barbara J</creatorcontrib><creatorcontrib>Rys, Paul N</creatorcontrib><creatorcontrib>Persing, David H</creatorcontrib><creatorcontrib>Steere, Allen C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nocton, James J</au><au>Dressler, Frank</au><au>Rutledge, Barbara J</au><au>Rys, Paul N</au><au>Persing, David H</au><au>Steere, Allen C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1994-01-27</date><risdate>1994</risdate><volume>330</volume><issue>4</issue><spage>229</spage><epage>234</epage><pages>229-234</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi
1
. Weeks to months after the onset of disease, approximately 60 percent of untreated patients begin to have brief, intermittent attacks of arthritis that may recur for several years
2
. A small percentage of these patients have continuous arthritis for one year or longer, a condition we have termed “chronic Lyme arthritis”
2
,
3
. Eventually, both intermittent and chronic Lyme arthritis resolve, even in untreated patients
2
,
4
.
Lyme arthritis can usually be treated successfully with either a one-month course of doxycycline or amoxicillin or a two-week course of intravenous . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8272083</pmid><doi>10.1056/NEJM199401273300401</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1994-01, Vol.330 (4), p.229-234 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76329747 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Adult Aged Arthritis, Infectious - diagnosis Arthritis, Infectious - microbiology Bacterial arthritis and osteitis Bacterial diseases Base Sequence Biological and medical sciences Borrelia burgdorferi Borrelia burgdorferi Group - genetics Borrelia burgdorferi Group - isolation & purification Child Child, Preschool Deoxyribonucleic acid DNA DNA Primers DNA Probes DNA, Bacterial - analysis Female Human bacterial diseases Humans Infectious diseases Lyme disease Lyme Disease - diagnosis Lyme Disease - microbiology Male Medical sciences Middle Aged Molecular Sequence Data Polymerase Chain Reaction Rheumatoid arthritis Synovial Fluid - microbiology |
| title | Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis |
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