Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study
Background. The influence of DNA content on prognosis in stomach cancer has been investigated rarely, and the results are controversial. Method. The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer. Results. In...
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| Veröffentlicht in: | Cancer 1994-01, Vol.73 (1), p.63-73 |
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| container_title | Cancer |
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| creator | Böttger, Thomas C. Störkel, Stefan Wellek, Stefan Stöckle, Michael Junginger, Theo |
| description | Background. The influence of DNA content on prognosis in stomach cancer has been investigated rarely, and the results are controversial.
Method. The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer.
Results. In the univariate analysis, the DNA content, tumor size, lymph node status, tumor stage, nuclear grade, and type of resection had a statistically significant influence on the prognosis. No association was found between the DNA content and the histomorphologic features. Apart from the operative procedure, the DNA content was the strongest indicator of prognosis in the multivariate analysis.
Conclusions. Further investigations are necessary to find out if DNA analysis can be performed preoperatively on material obtained by fine‐needle aspiration. |
| doi_str_mv | 10.1002/1097-0142(19940101)73:1<63::AID-CNCR2820730113>3.0.CO;2-P |
| format | Article |
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Method. The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer.
Results. In the univariate analysis, the DNA content, tumor size, lymph node status, tumor stage, nuclear grade, and type of resection had a statistically significant influence on the prognosis. No association was found between the DNA content and the histomorphologic features. Apart from the operative procedure, the DNA content was the strongest indicator of prognosis in the multivariate analysis.
Conclusions. Further investigations are necessary to find out if DNA analysis can be performed preoperatively on material obtained by fine‐needle aspiration.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19940101)73:1<63::AID-CNCR2820730113>3.0.CO;2-P</identifier><identifier>PMID: 8275439</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Cell Nucleus - ultrastructure ; Diploidy ; DNA analysis ; DNA, Neoplasm - analysis ; DNA, Neoplasm - genetics ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymph Node Excision ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Multivariate Analysis ; Neoplasm Staging ; Pancreatectomy - methods ; pancreatic cancer ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Polyploidy ; Prognosis ; prognostic factors ; relation between DNA content and histomorphologic parameters ; Survival Rate ; Tumors</subject><ispartof>Cancer, 1994-01, Vol.73 (1), p.63-73</ispartof><rights>Copyright © 1994 American Cancer Society</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5583-1e1e066af6d6c5f711039ee982ec4e365fed7f72347b88b03f0eb05f2353f353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3891741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8275439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Böttger, Thomas C.</creatorcontrib><creatorcontrib>Störkel, Stefan</creatorcontrib><creatorcontrib>Wellek, Stefan</creatorcontrib><creatorcontrib>Stöckle, Michael</creatorcontrib><creatorcontrib>Junginger, Theo</creatorcontrib><title>Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background. The influence of DNA content on prognosis in stomach cancer has been investigated rarely, and the results are controversial.
Method. The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer.
Results. In the univariate analysis, the DNA content, tumor size, lymph node status, tumor stage, nuclear grade, and type of resection had a statistically significant influence on the prognosis. No association was found between the DNA content and the histomorphologic features. Apart from the operative procedure, the DNA content was the strongest indicator of prognosis in the multivariate analysis.
Conclusions. Further investigations are necessary to find out if DNA analysis can be performed preoperatively on material obtained by fine‐needle aspiration.</description><subject>Biological and medical sciences</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Diploidy</subject><subject>DNA analysis</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Pancreatectomy - methods</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Polyploidy</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>relation between DNA content and histomorphologic parameters</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUdGK1DAUDaKs4-onCHkQ0YeOSW7btLMilK6rC8vOIvugTyGT3uxGOs2YtCvz92aYcUAfBB9CbnLOPRzOIaThbM4ZE-84q2XGeC7e8LrOGWf8rYQFf1_CYtFcnmftdftFVIJJYJzDB5izebs8E9nNIzI77j4mM8ZYlRU5fH1KnsX4PT2lKOCEnFRCpu96RoYLbUYfInWD7SccjBvuaJzCg3vQPdV2xEADRjSj8wP1lm70YALq0Rlq0ohhTht6ft1QPeh-G11MQ0c1vXdx9GsfNve-93eJHcep2z4nT6zuI7443Kfk9uLjbfs5u1p-umybq8wURQUZR46sLLUtu9IUVnLOoEasK4EmRygLi520UkAuV1W1YmAZrlhhBRRg0zklr_eym-B_TBhHtXbRYN_rAf0UlSxBVGWxI37bE03wMQa0ahPcWoet4kztqlC7ONUuTvW7CiVBcVWCUqkK9WcVChRT7VIJdZO0Xx5MTKs1dkflQ_YJf3XAdTS6tyHF6eKRBlXNZc4TrdvTfroet__j75_2_kLgF8HXs20</recordid><startdate>19940101</startdate><enddate>19940101</enddate><creator>Böttger, Thomas C.</creator><creator>Störkel, Stefan</creator><creator>Wellek, Stefan</creator><creator>Stöckle, Michael</creator><creator>Junginger, Theo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940101</creationdate><title>Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study</title><author>Böttger, Thomas C. ; Störkel, Stefan ; Wellek, Stefan ; Stöckle, Michael ; Junginger, Theo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5583-1e1e066af6d6c5f711039ee982ec4e365fed7f72347b88b03f0eb05f2353f353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Diploidy</topic><topic>DNA analysis</topic><topic>DNA, Neoplasm - analysis</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Pancreatectomy - methods</topic><topic>pancreatic cancer</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Polyploidy</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>relation between DNA content and histomorphologic parameters</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Böttger, Thomas C.</creatorcontrib><creatorcontrib>Störkel, Stefan</creatorcontrib><creatorcontrib>Wellek, Stefan</creatorcontrib><creatorcontrib>Stöckle, Michael</creatorcontrib><creatorcontrib>Junginger, Theo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Böttger, Thomas C.</au><au>Störkel, Stefan</au><au>Wellek, Stefan</au><au>Stöckle, Michael</au><au>Junginger, Theo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1994-01-01</date><risdate>1994</risdate><volume>73</volume><issue>1</issue><spage>63</spage><epage>73</epage><pages>63-73</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Background. The influence of DNA content on prognosis in stomach cancer has been investigated rarely, and the results are controversial.
Method. The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer.
Results. In the univariate analysis, the DNA content, tumor size, lymph node status, tumor stage, nuclear grade, and type of resection had a statistically significant influence on the prognosis. No association was found between the DNA content and the histomorphologic features. Apart from the operative procedure, the DNA content was the strongest indicator of prognosis in the multivariate analysis.
Conclusions. Further investigations are necessary to find out if DNA analysis can be performed preoperatively on material obtained by fine‐needle aspiration.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8275439</pmid><doi>10.1002/1097-0142(19940101)73:1<63::AID-CNCR2820730113>3.0.CO;2-P</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Cell Nucleus - ultrastructure Diploidy DNA analysis DNA, Neoplasm - analysis DNA, Neoplasm - genetics Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymph Node Excision Lymphatic Metastasis - pathology Male Medical sciences Multivariate Analysis Neoplasm Staging Pancreatectomy - methods pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Polyploidy Prognosis prognostic factors relation between DNA content and histomorphologic parameters Survival Rate Tumors |
| title | Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study |
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