Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer

The HER-2/neu protooncogene is amplified and overexpressed in 20-40% of invasive breast cancers. HER-2/neu protein overexpression is associated with aggressive disease and is an independent predictor of poor prognosis in several subsets of patients. The protein may also be related to cancer formatio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-01, Vol.54 (1), p.16-20
Hauptverfasser:	Disis, M L, Calenoff, E, McLaughlin, G, Murphy, A E, Chen, W, Groner, B, Jeschke, M, Lydon, N, McGlynn, E, Livingston, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - immunology Amino Acid Sequence Animals Antibodies, Neoplasm - analysis Antibodies, Neoplasm - blood Biomarkers, Tumor - chemistry Biomarkers, Tumor - immunology Breast Neoplasms - blood Breast Neoplasms - immunology Epitopes - analysis Female Humans Lymphocyte Activation Mice Middle Aged Molecular Sequence Data Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - immunology Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - immunology Receptor, ErbB-2 T-Lymphocytes - immunology Tumor Cells, Cultured
Online-Zugang:	Volltext
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