Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky
Critical tests were performed in 2009 and 2010 in four 2-year-old horses naturally infected with internal parasites. The horses were from a herd (Farm MC) where reduced activity of ivermectin and moxidectin on small strongyles was demonstrated previously from EPG (eggs/gram of feces) data in field t...
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| Veröffentlicht in: | Parasitology research (1987) 2010-11, Vol.107 (6), p.1495-1498 |
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| creator | Lyons, Eugene T. Tolliver, Sharon C. Kuzmina, Tetiana A. Collins, Sandra S. |
| description | Critical tests were performed in 2009 and 2010 in four 2-year-old horses naturally infected with internal parasites. The horses were from a herd (Farm MC) where reduced activity of ivermectin and moxidectin on small strongyles was demonstrated previously from EPG (eggs/gram of feces) data in field tests. Also, in critical tests in horses from the same herd, ivermectin was less effective on immature small strongyles in the lumen of the large intestine than when the drug was first marketed. The main interest in the present critical tests was to determine the efficacy of moxidectin (400 μg/kg) on small strongyles. This was done to try and find indications of why there has been a return of strongyle EPG counts sooner after treatment in field tests than when moxidectin was first commercially available. Removal of adult small strongyles for the four treated horses was >99% to 100%. Efficacy on immature (L
4
) small strongyles was 82%, 96%, 98%, and >99% for the individual horses. Identification of small strongyles recovered from two of the horses revealed that three genera and 11 species were present. Specimens of
Cylicocyclus ashworthi
are reported for the first time in horses in Kentucky although eggs of this species have been identified. Moxidectin, in the present study, was excellent on removing adult small strongyles but was less effective on immatures (L
4
) in the intestinal contents. The question as to why moxidectin efficacy on small strongyles has declined in field tests may have been answered at least to a certain extent. It seems that a significant factor is “quick development” of a few remaining immatures in the gut lumen of horses. Also, possible activity may have decreased on encysted stages in the large intestinal lining. In any event, after treatment of some horses with moxidectin, the life cycle of small strongyles is shorter now than at the onset of usage of this compound. |
| doi_str_mv | 10.1007/s00436-010-2025-5 |
| format | Article |
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4
) small strongyles was 82%, 96%, 98%, and >99% for the individual horses. Identification of small strongyles recovered from two of the horses revealed that three genera and 11 species were present. Specimens of
Cylicocyclus ashworthi
are reported for the first time in horses in Kentucky although eggs of this species have been identified. Moxidectin, in the present study, was excellent on removing adult small strongyles but was less effective on immatures (L
4
) in the intestinal contents. The question as to why moxidectin efficacy on small strongyles has declined in field tests may have been answered at least to a certain extent. It seems that a significant factor is “quick development” of a few remaining immatures in the gut lumen of horses. Also, possible activity may have decreased on encysted stages in the large intestinal lining. In any event, after treatment of some horses with moxidectin, the life cycle of small strongyles is shorter now than at the onset of usage of this compound.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-010-2025-5</identifier><identifier>PMID: 20714749</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Anthelmintics - administration & dosage ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Feces - parasitology ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Horse Diseases - drug therapy ; Horses ; Immunology ; Invertebrates ; Ivermectin ; Kentucky ; Macrolides - administration & dosage ; Medical Microbiology ; Microbiology ; Original Paper ; Parasite Egg Count ; Strongylida - classification ; Strongylida - isolation & purification ; Strongylida Infections - drug therapy ; Strongylida Infections - veterinary ; Strongyloidea - drug effects ; Treatment Outcome</subject><ispartof>Parasitology research (1987), 2010-11, Vol.107 (6), p.1495-1498</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-5783975f1d6b16a86180b91637bc0a5447eb16222527c927d87f7f58880fb25e3</citedby><cites>FETCH-LOGICAL-c473t-5783975f1d6b16a86180b91637bc0a5447eb16222527c927d87f7f58880fb25e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-010-2025-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-010-2025-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23403587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20714749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyons, Eugene T.</creatorcontrib><creatorcontrib>Tolliver, Sharon C.</creatorcontrib><creatorcontrib>Kuzmina, Tetiana A.</creatorcontrib><creatorcontrib>Collins, Sandra S.</creatorcontrib><title>Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Critical tests were performed in 2009 and 2010 in four 2-year-old horses naturally infected with internal parasites. The horses were from a herd (Farm MC) where reduced activity of ivermectin and moxidectin on small strongyles was demonstrated previously from EPG (eggs/gram of feces) data in field tests. Also, in critical tests in horses from the same herd, ivermectin was less effective on immature small strongyles in the lumen of the large intestine than when the drug was first marketed. The main interest in the present critical tests was to determine the efficacy of moxidectin (400 μg/kg) on small strongyles. This was done to try and find indications of why there has been a return of strongyle EPG counts sooner after treatment in field tests than when moxidectin was first commercially available. Removal of adult small strongyles for the four treated horses was >99% to 100%. Efficacy on immature (L
4
) small strongyles was 82%, 96%, 98%, and >99% for the individual horses. Identification of small strongyles recovered from two of the horses revealed that three genera and 11 species were present. Specimens of
Cylicocyclus ashworthi
are reported for the first time in horses in Kentucky although eggs of this species have been identified. Moxidectin, in the present study, was excellent on removing adult small strongyles but was less effective on immatures (L
4
) in the intestinal contents. The question as to why moxidectin efficacy on small strongyles has declined in field tests may have been answered at least to a certain extent. It seems that a significant factor is “quick development” of a few remaining immatures in the gut lumen of horses. Also, possible activity may have decreased on encysted stages in the large intestinal lining. In any event, after treatment of some horses with moxidectin, the life cycle of small strongyles is shorter now than at the onset of usage of this compound.</description><subject>Animals</subject><subject>Anthelmintics - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Feces - parasitology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Horse Diseases - drug therapy</subject><subject>Horses</subject><subject>Immunology</subject><subject>Invertebrates</subject><subject>Ivermectin</subject><subject>Kentucky</subject><subject>Macrolides - administration & dosage</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Original Paper</subject><subject>Parasite Egg Count</subject><subject>Strongylida - classification</subject><subject>Strongylida - isolation & purification</subject><subject>Strongylida Infections - drug therapy</subject><subject>Strongylida Infections - veterinary</subject><subject>Strongyloidea - drug effects</subject><subject>Treatment Outcome</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks9u1DAQxiMEosvCA3BBlhAqlxT_iePkWK0oICpxgbPl2ONdl8QudlLYd-IhmdUuICRU-WB75vd5ZuSvqp4zesEoVW8KpY1oa8pozSmXtXxQrVgjeM16KR9WK9rjmTImzqonpdxQylTbNI-rM04Va1TTr6qfmxzmYM1IZihzIXBnxsXMIW4JeI8JuyfJkyn9CA4sxonZmhDLTMpkxpGUOae43Y9QCOZ2KRc8-ZwmYsgOsiM-ZfJ9F-yOZHCLBUcMPnMX5j3ZGUcGgIjMEt1B7wOM7tQJXjcQ54ytfcR9sV_3T6tH3owFnp32dfXl6u3nzfv6-tO7D5vL69o2Ssy1VJ3olfTMtQNrTdeyjg49a4UaLDWyaRRgnHMuubI9V65TXnnZdR31A5cg1tX58d3bnL4t2I2eQrEwjiZCWopWreCIK4Hk63tJpqRoWiF4h-jLI7o1I-gQfcLZ7AHXl6JjVOKXUKQu_kPhcjAFmyL4gPF_BOwosDmVksHr2xwmk_eaUX1wiT66RKNL9MElWqLmxanrZZjA_VH8tgUCr06AKegNn020ofzlBBaWOP-64keuYCpuIeubtOSIf3NP9V9yUdRW</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Lyons, Eugene T.</creator><creator>Tolliver, Sharon C.</creator><creator>Kuzmina, Tetiana A.</creator><creator>Collins, Sandra S.</creator><general>Springer-Verlag</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky</title><author>Lyons, Eugene T. ; Tolliver, Sharon C. ; Kuzmina, Tetiana A. ; Collins, Sandra S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-5783975f1d6b16a86180b91637bc0a5447eb16222527c927d87f7f58880fb25e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anthelmintics - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Feces - parasitology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Horse Diseases - drug therapy</topic><topic>Horses</topic><topic>Immunology</topic><topic>Invertebrates</topic><topic>Ivermectin</topic><topic>Kentucky</topic><topic>Macrolides - administration & dosage</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Original Paper</topic><topic>Parasite Egg Count</topic><topic>Strongylida - classification</topic><topic>Strongylida - isolation & purification</topic><topic>Strongylida Infections - drug therapy</topic><topic>Strongylida Infections - veterinary</topic><topic>Strongyloidea - drug effects</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyons, Eugene T.</creatorcontrib><creatorcontrib>Tolliver, Sharon C.</creatorcontrib><creatorcontrib>Kuzmina, Tetiana A.</creatorcontrib><creatorcontrib>Collins, Sandra S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyons, Eugene T.</au><au>Tolliver, Sharon C.</au><au>Kuzmina, Tetiana A.</au><au>Collins, Sandra S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>107</volume><issue>6</issue><spage>1495</spage><epage>1498</epage><pages>1495-1498</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>Critical tests were performed in 2009 and 2010 in four 2-year-old horses naturally infected with internal parasites. The horses were from a herd (Farm MC) where reduced activity of ivermectin and moxidectin on small strongyles was demonstrated previously from EPG (eggs/gram of feces) data in field tests. Also, in critical tests in horses from the same herd, ivermectin was less effective on immature small strongyles in the lumen of the large intestine than when the drug was first marketed. The main interest in the present critical tests was to determine the efficacy of moxidectin (400 μg/kg) on small strongyles. This was done to try and find indications of why there has been a return of strongyle EPG counts sooner after treatment in field tests than when moxidectin was first commercially available. Removal of adult small strongyles for the four treated horses was >99% to 100%. Efficacy on immature (L
4
) small strongyles was 82%, 96%, 98%, and >99% for the individual horses. Identification of small strongyles recovered from two of the horses revealed that three genera and 11 species were present. Specimens of
Cylicocyclus ashworthi
are reported for the first time in horses in Kentucky although eggs of this species have been identified. Moxidectin, in the present study, was excellent on removing adult small strongyles but was less effective on immatures (L
4
) in the intestinal contents. The question as to why moxidectin efficacy on small strongyles has declined in field tests may have been answered at least to a certain extent. It seems that a significant factor is “quick development” of a few remaining immatures in the gut lumen of horses. Also, possible activity may have decreased on encysted stages in the large intestinal lining. In any event, after treatment of some horses with moxidectin, the life cycle of small strongyles is shorter now than at the onset of usage of this compound.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20714749</pmid><doi>10.1007/s00436-010-2025-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2010-11, Vol.107 (6), p.1495-1498 |
| issn | 0932-0113 1432-1955 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Anthelmintics - administration & dosage Biological and medical sciences Biomedical and Life Sciences Biomedicine Feces - parasitology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Horse Diseases - drug therapy Horses Immunology Invertebrates Ivermectin Kentucky Macrolides - administration & dosage Medical Microbiology Microbiology Original Paper Parasite Egg Count Strongylida - classification Strongylida - isolation & purification Strongylida Infections - drug therapy Strongylida Infections - veterinary Strongyloidea - drug effects Treatment Outcome |
| title | Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky |
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