Regulation of cytokine gene expression in T helper cell subsets

We have examined the transcriptional regulation of the Th1-specific IL-2 gene and the Th2-specific IL-4 gene by transient transfection of promoter-chloramphenicol acetyl transferase (CAT) constructs into T cell clones and by electrophoretic mobility shift assays. Transfection of the Th2 clone D10.G4...

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Veröffentlicht in:	The Journal of immunology (1950) 1994, Vol.152 (1), p.77-86
Hauptverfasser:	LEDERER, J. A, LIOU, J. S, TODD, M. D, GLIMCHER, L. H, LICHTMAN, A. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Base Sequence Biological and medical sciences Cell Line Clone Cells DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Immunobiology Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Lymphokines, interleukins ( function, expression) Mice Molecular Sequence Data Nuclear Proteins - physiology Promoter Regions, Genetic Regulatory factors and their cellular receptors T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology Transcription, Genetic
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