Structural and immunologic analysis of gene triplications in the Ig heavy chain constant region locus

The Ig H chain C region is a multigene family often involved in genomic rearrangements leading to deleted and duplicated haplotypes, most probably through unequal crossing over between homologous regions within the locus. The frequency of these haplotypes in Italy is around 2.7% each. Using PFGE ana...

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Veröffentlicht in:	The Journal of immunology (1950) 1994, Vol.152 (1), p.129-135
Hauptverfasser:	BRUSCO, A, CARIOTA, U, CARBONARA, A. O, BOTTARO, A, BOCCAZZI, C, PLEBANI, A, UGAZIO, A. G, GALANELLO, R, VAN LEEUWEN, A. M, DELANGE, G. G, DEPELCHIN, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Deletion Gene Rearrangement Genes, Immunoglobulin Genes. Genome Genotype Haplotypes Humans Immunoglobulin Class Switching Immunoglobulin Constant Regions - genetics Immunoglobulin Heavy Chains - genetics Molecular and cellular biology Molecular genetics Multigene Family Pedigree
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