Characterisation of fenofibrate dissolution delivered by a self-microemulsifying drug-delivery system

Objectives This study attempted to characterise the in‐vitro release profiles of fenofibrate (FFB) from a self‐microemulsifying drug‐delivery system (SMEDDS) for optimising formulation factors and dissolution conditions for in‐vivo absorption. Methods The study was conducted by profiling the relea...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2010-12, Vol.62 (12), p.1685-1696
Hauptverfasser:	Wei, Jyh-Ding, Ho, Hsiu-O, Chen, Chien-Ho, Ke, Wen-Tin, Chen, Eric Tsu-Hsin, Sheu, Ming-Thau
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Availability d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) dissolution Drug Delivery Systems Emulsifying Agents Excipients fenofibrate Fenofibrate - administration & dosage Fenofibrate - chemistry Fenofibrate - pharmacokinetics Hypolipidemic Agents - administration & dosage Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacokinetics microemulsion Polyethylene Glycols Polysorbates Propylene Glycol self-microemulsifying drug-delivery system (SMEDDS) Sodium Dodecyl Sulfate Solubility Triglycerides Viscosity Vitamin E - analogs & derivatives
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