Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer
Abstract Background and purpose The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy. Materials an...
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| Veröffentlicht in: | Radiotherapy and oncology 2010-11, Vol.97 (2), p.258-262 |
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| container_title | Radiotherapy and oncology |
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| creator | Oskam, Inge M Verdonck-de Leeuw, Irma M Aaronson, Neil K Kuik, Dirk J Bree, Remco de Doornaert, Patricia Langendijk, Johannes A Leemans, René C |
| description | Abstract Background and purpose The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy. Materials and methods Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale). Results Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning. Conclusion Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer. |
| doi_str_mv | 10.1016/j.radonc.2010.02.005 |
| format | Article |
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Materials and methods Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale). Results Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning. Conclusion Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2010.02.005</identifier><identifier>PMID: 20189668</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Disease-Free Survival ; Female ; Head and neck cancer ; Health-related quality of life ; Hematology, Oncology and Palliative Medicine ; Humans ; Male ; Middle Aged ; Mouth Neoplasms - radiotherapy ; Mouth Neoplasms - surgery ; Neoplasm Staging ; Oropharyngeal cancer ; Oropharyngeal Neoplasms - radiotherapy ; Oropharyngeal Neoplasms - surgery ; Predictive Value of Tests ; Prospective Studies ; Quality of Life ; Survival</subject><ispartof>Radiotherapy and oncology, 2010-11, Vol.97 (2), p.258-262</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-4dbb19c0c4c70b82bc45da6d0f95d37d61fcc46eb76494e4985224a6941ca0ee3</citedby><cites>FETCH-LOGICAL-c416t-4dbb19c0c4c70b82bc45da6d0f95d37d61fcc46eb76494e4985224a6941ca0ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167814010000824$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20189668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oskam, Inge M</creatorcontrib><creatorcontrib>Verdonck-de Leeuw, Irma M</creatorcontrib><creatorcontrib>Aaronson, Neil K</creatorcontrib><creatorcontrib>Kuik, Dirk J</creatorcontrib><creatorcontrib>Bree, Remco de</creatorcontrib><creatorcontrib>Doornaert, Patricia</creatorcontrib><creatorcontrib>Langendijk, Johannes A</creatorcontrib><creatorcontrib>Leemans, René C</creatorcontrib><title>Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Abstract Background and purpose The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy. Materials and methods Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale). Results Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning. Conclusion Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Head and neck cancer</subject><subject>Health-related quality of life</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - radiotherapy</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neoplasm Staging</subject><subject>Oropharyngeal cancer</subject><subject>Oropharyngeal Neoplasms - radiotherapy</subject><subject>Oropharyngeal Neoplasms - surgery</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Survival</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQtBCIHRb-ACHfOGVoZzxOwgFpteIlrYQQcLYcu7PjIRMH28kq38OP0mEWDlw4We6u6kdVM_ZcwFaAUK-O22hcGOy2BApBuQXYP2AbUVdNAXVdPWQbglVFLSRcsCcpHQGghF31mF0QpW6Uqjfs5-fJ9D4vPHS89x1yk_gY0XmbQ1yDaYqzn03_ml9RIqQRbfYz8pQnR6yBjyZ7HHLiOaLJ6Pidzwduw6n1A_2If4tx4WZwnAb2IR8wmnHhHdU3bjaDJVSIpv8NCTGMBxOX4RYpYtdsfMoedaZP-Oz-vWTf3r39ev2huPn0_uP11U1hpVC5kK5tRWPBSltBW5etlXtnlIOu2btd5ZTorJUK20rJRqJs6n1ZSqMaKawBxN0le3muS3v-mDBlffLJYt-bAcOUdKV2olKlBELKM9KSIilip8foTzS2FqBXd_RRn93RqzsaSk3uEO3FfYOpPaH7S_pjBwHenAFIa84eo06WxCWFfCTdtQv-fx3-LWB7P3hr-u-4YDqGKQ4koRY6EUF_WS9kPRBBtwF1KXe_AFKfu4U</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Oskam, Inge M</creator><creator>Verdonck-de Leeuw, Irma M</creator><creator>Aaronson, Neil K</creator><creator>Kuik, Dirk J</creator><creator>Bree, Remco de</creator><creator>Doornaert, Patricia</creator><creator>Langendijk, Johannes A</creator><creator>Leemans, René C</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer</title><author>Oskam, Inge M ; Verdonck-de Leeuw, Irma M ; Aaronson, Neil K ; Kuik, Dirk J ; Bree, Remco de ; Doornaert, Patricia ; Langendijk, Johannes A ; Leemans, René C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-4dbb19c0c4c70b82bc45da6d0f95d37d61fcc46eb76494e4985224a6941ca0ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Head and neck cancer</topic><topic>Health-related quality of life</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - radiotherapy</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neoplasm Staging</topic><topic>Oropharyngeal cancer</topic><topic>Oropharyngeal Neoplasms - radiotherapy</topic><topic>Oropharyngeal Neoplasms - surgery</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oskam, Inge M</creatorcontrib><creatorcontrib>Verdonck-de Leeuw, Irma M</creatorcontrib><creatorcontrib>Aaronson, Neil K</creatorcontrib><creatorcontrib>Kuik, Dirk J</creatorcontrib><creatorcontrib>Bree, Remco de</creatorcontrib><creatorcontrib>Doornaert, Patricia</creatorcontrib><creatorcontrib>Langendijk, Johannes A</creatorcontrib><creatorcontrib>Leemans, René C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oskam, Inge M</au><au>Verdonck-de Leeuw, Irma M</au><au>Aaronson, Neil K</au><au>Kuik, Dirk J</au><au>Bree, Remco de</au><au>Doornaert, Patricia</au><au>Langendijk, Johannes A</au><au>Leemans, René C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>97</volume><issue>2</issue><spage>258</spage><epage>262</epage><pages>258-262</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Abstract Background and purpose The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy. Materials and methods Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale). Results Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning. Conclusion Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20189668</pmid><doi>10.1016/j.radonc.2010.02.005</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Disease-Free Survival Female Head and neck cancer Health-related quality of life Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Mouth Neoplasms - radiotherapy Mouth Neoplasms - surgery Neoplasm Staging Oropharyngeal cancer Oropharyngeal Neoplasms - radiotherapy Oropharyngeal Neoplasms - surgery Predictive Value of Tests Prospective Studies Quality of Life Survival |
| title | Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer |
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