Evaluation of Hypoglycemic Activity of Inorganic Constituents in Nelumbo nucifera Seeds on Streptozotocin-Induced Diabetes in Rats
The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hyp...
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| Veröffentlicht in: | Biological trace element research 2010-12, Vol.138 (1-3), p.226-237 |
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| container_title | Biological trace element research |
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| creator | Mani, Sivasankari S Subramanian, Iyyam Pillai Pillai, Subramanian Sorimuthu Muthusamy, Kandaswamy |
| description | The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic properties of seed ash on streptozotocin-induced diabetes in rats. Diabetic rats treated with lotus seed ash at a concentration of 200 mg/kg body weight orally for 30 days exhibited significant hypoglycemic activity. The presence of trace elements in appreciable amounts in the seeds may play a direct or indirect role on insulin secretion or its action in a synergetic manner. The hypoglycemic activity of the ash was comparable with glyclazide. The role of trace elements in disorders related to diabetes is also discussed briefly. |
| doi_str_mv | 10.1007/s12011-010-8614-4 |
| format | Article |
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The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic properties of seed ash on streptozotocin-induced diabetes in rats. Diabetic rats treated with lotus seed ash at a concentration of 200 mg/kg body weight orally for 30 days exhibited significant hypoglycemic activity. The presence of trace elements in appreciable amounts in the seeds may play a direct or indirect role on insulin secretion or its action in a synergetic manner. The hypoglycemic activity of the ash was comparable with glyclazide. The role of trace elements in disorders related to diabetes is also discussed briefly.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-010-8614-4</identifier><identifier>PMID: 20165930</identifier><language>eng</language><publisher>New York: New York : Humana Press Inc</publisher><subject>Animals ; Atomic absorption spectroscopy ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood Glucose - drug effects ; Body weight ; Diabetes ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Hypoglycemia ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Inorganic chemistry ; Life Sciences ; Male ; Nelumbo - chemistry ; Nutrition ; Oncology ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; Rodents ; Seeds - chemistry ; Spectral analysis ; Trace elements</subject><ispartof>Biological trace element research, 2010-12, Vol.138 (1-3), p.226-237</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-6aa3092d1eef187ecf20d0737620ff3a0a67edb3333f37354e6c8ac33ffacab03</citedby><cites>FETCH-LOGICAL-c460t-6aa3092d1eef187ecf20d0737620ff3a0a67edb3333f37354e6c8ac33ffacab03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-010-8614-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-010-8614-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20165930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mani, Sivasankari S</creatorcontrib><creatorcontrib>Subramanian, Iyyam Pillai</creatorcontrib><creatorcontrib>Pillai, Subramanian Sorimuthu</creatorcontrib><creatorcontrib>Muthusamy, Kandaswamy</creatorcontrib><title>Evaluation of Hypoglycemic Activity of Inorganic Constituents in Nelumbo nucifera Seeds on Streptozotocin-Induced Diabetes in Rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic properties of seed ash on streptozotocin-induced diabetes in rats. Diabetic rats treated with lotus seed ash at a concentration of 200 mg/kg body weight orally for 30 days exhibited significant hypoglycemic activity. The presence of trace elements in appreciable amounts in the seeds may play a direct or indirect role on insulin secretion or its action in a synergetic manner. The hypoglycemic activity of the ash was comparable with glyclazide. The role of trace elements in disorders related to diabetes is also discussed briefly.</description><subject>Animals</subject><subject>Atomic absorption spectroscopy</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood Glucose - drug effects</subject><subject>Body weight</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Hypoglycemia</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Inorganic chemistry</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Nelumbo - chemistry</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Seeds - 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| ispartof | Biological trace element research, 2010-12, Vol.138 (1-3), p.226-237 |
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| subjects | Animals Atomic absorption spectroscopy Biochemistry Biomedical and Life Sciences Biotechnology Blood Glucose - drug effects Body weight Diabetes Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Hypoglycemia Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Inorganic chemistry Life Sciences Male Nelumbo - chemistry Nutrition Oncology Plant Extracts - therapeutic use Rats Rats, Wistar Rodents Seeds - chemistry Spectral analysis Trace elements |
| title | Evaluation of Hypoglycemic Activity of Inorganic Constituents in Nelumbo nucifera Seeds on Streptozotocin-Induced Diabetes in Rats |
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