Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1

Microsomal prostaglandin E(2) synthase (mPGES-1) represents a potential target for novel analgesic and anti-inflammatory agents. High-throughput screening identified several leads of mPGES-1 inhibitors which were further optimized for potency and selectivity. A series of inhibitors bearing a biaryl...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-12, Vol.20 (23), p.6978-6982
Hauptverfasser:	WU, Tom Y. H, JUTEAU, Hélène, BRIDEAU, Christine, DUCHARME, Yves, FRIESEN, Richard W, GUIRAL, Sébastien, DUFRESNE, Lynn, POIRIER, Hugo, SALEM, Myriam, RIENDEAU, Denis, MANCINI, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cell Line Dinoprostone - antagonists & inhibitors Dinoprostone - biosynthesis High-Throughput Screening Assays Imidazoles - chemistry Imidazoles - pharmacology Intramolecular Oxidoreductases - antagonists & inhibitors Medical sciences Mice Microsomes - enzymology Pharmacology. Drug treatments Prostaglandin-E Synthases
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