Xenogeneic ex vivo hemoperfusion of rhesus monkey livers with human blood
In order to copy the clinical situation of concordant xenotransplantation, Rhesus Monkey livers were hemoperfused with human blood. Changes of immunological (TNFα, IL‐1β, IL‐2, IL‐2R, IL‐6, IFNy, TXB2, 6kPGF1α, sICAM‐1, SELAM‐1, sHLA‐I‐Ag) and pathophysiological (GOT, GPT, LDH, CK) parameters were f...
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| Veröffentlicht in: | Transplant international 1994, Vol.7 (s1), p.643-646 |
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| creator | Pöhlein, Ch Lemmens, P. Hammer, C. Lemmens, P. Schon, M. R. Neuhaus, P. Thiery, J. |
| description | In order to copy the clinical situation of concordant xenotransplantation, Rhesus Monkey livers were hemoperfused with human blood. Changes of immunological (TNFα, IL‐1β, IL‐2, IL‐2R, IL‐6, IFNy, TXB2, 6kPGF1α, sICAM‐1, SELAM‐1, sHLA‐I‐Ag) and pathophysiological (GOT, GPT, LDH, CK) parameters were followed. Our experiment proves that all phenomena start in the first hour of xenogeneic blood circulation. Xenogeneic rejection in our concordant system is surprisingly severe. Preformed natural antibodies only cannot be the reason of such a damage [5, 6]. We think that beside other important immunological mechanisms, humoral mediators play a considerable role at the beginning of a xenogeneic rejection. |
| doi_str_mv | 10.1111/j.1432-2277.1994.tb01463.x |
| format | Article |
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We think that beside other important immunological mechanisms, humoral mediators play a considerable role at the beginning of a xenogeneic rejection.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.1994.tb01463.x</identifier><identifier>PMID: 11271329</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adhesion molecules ; Animals ; Aspartate Aminotransferases - blood ; Blood ; Creatine Kinase - blood ; Cytokines ; Cytokines - analysis ; E-Selectin - analysis ; Eicosanoids ; Ex vivo hemoperfusion ; Graft Rejection - immunology ; Histocompatibility Antigens Class I - analysis ; Humans ; In Vitro Techniques ; Intercellular Adhesion Molecule-1 - analysis ; L-Lactate Dehydrogenase - blood ; Liver ; Liver - immunology ; Liver - physiology ; Macaca mulatta ; Mediators ; Perfusion ; Perfusion circuit ; Primate ; Prostaglandins - analysis ; SHLA I Ag ; Time Factors ; Transplantation, Heterologous - immunology ; Xenogeneic rejection ; Xenograft</subject><ispartof>Transplant international, 1994, Vol.7 (s1), p.643-646</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2853-b76567ee3c170d45b9437c5fcefbd114d9496673dd523bf63bf58f3420fcdd8b3</citedby><cites>FETCH-LOGICAL-c2853-b76567ee3c170d45b9437c5fcefbd114d9496673dd523bf63bf58f3420fcdd8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11271329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pöhlein, Ch</creatorcontrib><creatorcontrib>Lemmens, P.</creatorcontrib><creatorcontrib>Hammer, C.</creatorcontrib><creatorcontrib>Lemmens, P.</creatorcontrib><creatorcontrib>Schon, M. R.</creatorcontrib><creatorcontrib>Neuhaus, P.</creatorcontrib><creatorcontrib>Thiery, J.</creatorcontrib><title>Xenogeneic ex vivo hemoperfusion of rhesus monkey livers with human blood</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>In order to copy the clinical situation of concordant xenotransplantation, Rhesus Monkey livers were hemoperfused with human blood. Changes of immunological (TNFα, IL‐1β, IL‐2, IL‐2R, IL‐6, IFNy, TXB2, 6kPGF1α, sICAM‐1, SELAM‐1, sHLA‐I‐Ag) and pathophysiological (GOT, GPT, LDH, CK) parameters were followed. Our experiment proves that all phenomena start in the first hour of xenogeneic blood circulation. Xenogeneic rejection in our concordant system is surprisingly severe. Preformed natural antibodies only cannot be the reason of such a damage [5, 6]. We think that beside other important immunological mechanisms, humoral mediators play a considerable role at the beginning of a xenogeneic rejection.</description><subject>Adhesion molecules</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Blood</subject><subject>Creatine Kinase - blood</subject><subject>Cytokines</subject><subject>Cytokines - analysis</subject><subject>E-Selectin - analysis</subject><subject>Eicosanoids</subject><subject>Ex vivo hemoperfusion</subject><subject>Graft Rejection - immunology</subject><subject>Histocompatibility Antigens Class I - analysis</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Intercellular Adhesion Molecule-1 - analysis</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver</subject><subject>Liver - immunology</subject><subject>Liver - physiology</subject><subject>Macaca mulatta</subject><subject>Mediators</subject><subject>Perfusion</subject><subject>Perfusion circuit</subject><subject>Primate</subject><subject>Prostaglandins - analysis</subject><subject>SHLA I Ag</subject><subject>Time Factors</subject><subject>Transplantation, Heterologous - immunology</subject><subject>Xenogeneic rejection</subject><subject>Xenograft</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtLw0AQxxdRbK1-BVk8eEvcV7JdD4IUHwVBkAreliQ7a1KTbM02fXx7Exr07MAwh_k_4IfQFSUh7eZmGVLBWcCYlCFVSoTrlFAR83B3hMa_r2M0JoqLgEylGKEz75eEEDaNyCkaUcok5UyN0fwDavcJNRQZhh3eFBuHc6jcChrb-sLV2Fnc5OBbjytXf8Eel8UGGo-3xTrHeVslNU5L58w5OrFJ6eFiuBP0_viwmD0HL69P89n9S5B15TxIZRzFEoBnVBIjolQJLrPIZmBTQ6kwSqg4ltyYiPHUxt1GU8sFIzYzZpryCbo-5K4a992CX-uq8BmUZVKDa72WMaeCUtUJbw_CrHHeN2D1qimqpNlrSnQPUi91T0v3tHQPUg8g9a4zXw4tbVqB-bMO5DrB3UGwLUrY_yNaL97mseD8B0xXg_g</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Pöhlein, Ch</creator><creator>Lemmens, P.</creator><creator>Hammer, C.</creator><creator>Lemmens, P.</creator><creator>Schon, M. R.</creator><creator>Neuhaus, P.</creator><creator>Thiery, J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Xenogeneic ex vivo hemoperfusion of rhesus monkey livers with human blood</title><author>Pöhlein, Ch ; Lemmens, P. ; Hammer, C. ; Lemmens, P. ; Schon, M. R. ; Neuhaus, P. ; Thiery, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2853-b76567ee3c170d45b9437c5fcefbd114d9496673dd523bf63bf58f3420fcdd8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adhesion molecules</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Blood</topic><topic>Creatine Kinase - blood</topic><topic>Cytokines</topic><topic>Cytokines - analysis</topic><topic>E-Selectin - analysis</topic><topic>Eicosanoids</topic><topic>Ex vivo hemoperfusion</topic><topic>Graft Rejection - immunology</topic><topic>Histocompatibility Antigens Class I - analysis</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Intercellular Adhesion Molecule-1 - analysis</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver</topic><topic>Liver - immunology</topic><topic>Liver - physiology</topic><topic>Macaca mulatta</topic><topic>Mediators</topic><topic>Perfusion</topic><topic>Perfusion circuit</topic><topic>Primate</topic><topic>Prostaglandins - analysis</topic><topic>SHLA I Ag</topic><topic>Time Factors</topic><topic>Transplantation, Heterologous - immunology</topic><topic>Xenogeneic rejection</topic><topic>Xenograft</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pöhlein, Ch</creatorcontrib><creatorcontrib>Lemmens, P.</creatorcontrib><creatorcontrib>Hammer, C.</creatorcontrib><creatorcontrib>Lemmens, P.</creatorcontrib><creatorcontrib>Schon, M. R.</creatorcontrib><creatorcontrib>Neuhaus, P.</creatorcontrib><creatorcontrib>Thiery, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pöhlein, Ch</au><au>Lemmens, P.</au><au>Hammer, C.</au><au>Lemmens, P.</au><au>Schon, M. R.</au><au>Neuhaus, P.</au><au>Thiery, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenogeneic ex vivo hemoperfusion of rhesus monkey livers with human blood</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>1994</date><risdate>1994</risdate><volume>7</volume><issue>s1</issue><spage>643</spage><epage>646</epage><pages>643-646</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>In order to copy the clinical situation of concordant xenotransplantation, Rhesus Monkey livers were hemoperfused with human blood. Changes of immunological (TNFα, IL‐1β, IL‐2, IL‐2R, IL‐6, IFNy, TXB2, 6kPGF1α, sICAM‐1, SELAM‐1, sHLA‐I‐Ag) and pathophysiological (GOT, GPT, LDH, CK) parameters were followed. Our experiment proves that all phenomena start in the first hour of xenogeneic blood circulation. Xenogeneic rejection in our concordant system is surprisingly severe. Preformed natural antibodies only cannot be the reason of such a damage [5, 6]. We think that beside other important immunological mechanisms, humoral mediators play a considerable role at the beginning of a xenogeneic rejection.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11271329</pmid><doi>10.1111/j.1432-2277.1994.tb01463.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 1994, Vol.7 (s1), p.643-646 |
| issn | 0934-0874 1432-2277 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adhesion molecules Animals Aspartate Aminotransferases - blood Blood Creatine Kinase - blood Cytokines Cytokines - analysis E-Selectin - analysis Eicosanoids Ex vivo hemoperfusion Graft Rejection - immunology Histocompatibility Antigens Class I - analysis Humans In Vitro Techniques Intercellular Adhesion Molecule-1 - analysis L-Lactate Dehydrogenase - blood Liver Liver - immunology Liver - physiology Macaca mulatta Mediators Perfusion Perfusion circuit Primate Prostaglandins - analysis SHLA I Ag Time Factors Transplantation, Heterologous - immunology Xenogeneic rejection Xenograft |
| title | Xenogeneic ex vivo hemoperfusion of rhesus monkey livers with human blood |
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