Placental transfer and disposition of bilirubin in the pregnant monkey
The placental transfer and disposition of conjugated and unconjugated bilirubin was studied in the pregnant rhesus monkey at term. The data indicate bidirectional placental transfer of unconjugated bilirubin, whereas only small quantities of conjugated bilirubin cross the placenta. The small quantit...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1969-04, Vol.103 (7), p.950-958 |
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| container_end_page | 958 |
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| container_issue | 7 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 103 |
| creator | Bashore, R.A. Smith, F. Schenker, S. |
| description | The placental transfer and disposition of conjugated and unconjugated bilirubin was studied in the pregnant rhesus monkey at term. The data indicate bidirectional placental transfer of unconjugated bilirubin, whereas only small quantities of conjugated bilirubin cross the placenta. The small quantity of unconjugated bilirubin excreted into the fetal biliary tract indicates that normally the placenta is the primary route of disposal of unconjugated bilirubin of fetal origin. Unconjugated bilirubin readily enters amniotic fluid from the maternal circulation. The data also indicate that the monkey fetus exhibits an impairment of hepatic excretion of conjugated bilirubin. |
| doi_str_mv | 10.1016/S0002-9378(16)34445-3 |
| format | Article |
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The data indicate bidirectional placental transfer of unconjugated bilirubin, whereas only small quantities of conjugated bilirubin cross the placenta. The small quantity of unconjugated bilirubin excreted into the fetal biliary tract indicates that normally the placenta is the primary route of disposal of unconjugated bilirubin of fetal origin. Unconjugated bilirubin readily enters amniotic fluid from the maternal circulation. The data also indicate that the monkey fetus exhibits an impairment of hepatic excretion of conjugated bilirubin.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(16)34445-3</identifier><identifier>PMID: 4975449</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amniotic Fluid - analysis ; Animals ; Bile - analysis ; Bilirubin - metabolism ; Carbon Isotopes ; Female ; Fetus - analysis ; Haplorhini ; Liver - metabolism ; Maternal-Fetal Exchange ; Metabolic Clearance Rate ; Placenta - physiology ; Pregnancy ; Pregnancy, Animal</subject><ispartof>American journal of obstetrics and gynecology, 1969-04, Vol.103 (7), p.950-958</ispartof><rights>1969 The C. V. 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The data indicate bidirectional placental transfer of unconjugated bilirubin, whereas only small quantities of conjugated bilirubin cross the placenta. The small quantity of unconjugated bilirubin excreted into the fetal biliary tract indicates that normally the placenta is the primary route of disposal of unconjugated bilirubin of fetal origin. Unconjugated bilirubin readily enters amniotic fluid from the maternal circulation. The data also indicate that the monkey fetus exhibits an impairment of hepatic excretion of conjugated bilirubin.</description><subject>Amniotic Fluid - analysis</subject><subject>Animals</subject><subject>Bile - analysis</subject><subject>Bilirubin - metabolism</subject><subject>Carbon Isotopes</subject><subject>Female</subject><subject>Fetus - analysis</subject><subject>Haplorhini</subject><subject>Liver - metabolism</subject><subject>Maternal-Fetal Exchange</subject><subject>Metabolic Clearance Rate</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLw0AQhRdRaq3-hEKeRB-ie8sm-yRSrAoFBfV52ctEV9NN3U2E_nvTC74KA8NhzplhPoSmBF8RTMT1C8aY5pKV1QURl4xzXuTsAI0JlmUuKlEdovGf5RidpPS5kVTSERpxWRacyzGaPzfaQuh0k3VRh1RDzHRwmfNp1Sbf-TZkbZ0Z3_jYGx-yoboPyFYR3oMOXbZswxesT9FRrZsEZ_s-QW_zu9fZQ754un-c3S5yywTucllXkgEh0onaacxtxbWoqakKZgtGeSHAMaaZMaLAzlJNaMkMr4yQjhJD2QSd7_auYvvdQ-rU0icLTaMDtH1SpWCEcSIHY7Ez2timFKFWq-iXOq4VwWrDT235qQ0cNagtP8WG3HR_oDdLcH-pPbBhfrObw_Dlj4eokvUQLDgfwXbKtf6fC78UcX93</recordid><startdate>19690401</startdate><enddate>19690401</enddate><creator>Bashore, R.A.</creator><creator>Smith, F.</creator><creator>Schenker, S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690401</creationdate><title>Placental transfer and disposition of bilirubin in the pregnant monkey</title><author>Bashore, R.A. ; Smith, F. ; Schenker, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-9f893e119d6fda04c84a6f2b853c532456ed33a3bb650dc2a1273b48b69d21b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Amniotic Fluid - analysis</topic><topic>Animals</topic><topic>Bile - analysis</topic><topic>Bilirubin - metabolism</topic><topic>Carbon Isotopes</topic><topic>Female</topic><topic>Fetus - analysis</topic><topic>Haplorhini</topic><topic>Liver - metabolism</topic><topic>Maternal-Fetal Exchange</topic><topic>Metabolic Clearance Rate</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bashore, R.A.</creatorcontrib><creatorcontrib>Smith, F.</creatorcontrib><creatorcontrib>Schenker, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bashore, R.A.</au><au>Smith, F.</au><au>Schenker, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental transfer and disposition of bilirubin in the pregnant monkey</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1969-04-01</date><risdate>1969</risdate><volume>103</volume><issue>7</issue><spage>950</spage><epage>958</epage><pages>950-958</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>The placental transfer and disposition of conjugated and unconjugated bilirubin was studied in the pregnant rhesus monkey at term. The data indicate bidirectional placental transfer of unconjugated bilirubin, whereas only small quantities of conjugated bilirubin cross the placenta. The small quantity of unconjugated bilirubin excreted into the fetal biliary tract indicates that normally the placenta is the primary route of disposal of unconjugated bilirubin of fetal origin. Unconjugated bilirubin readily enters amniotic fluid from the maternal circulation. The data also indicate that the monkey fetus exhibits an impairment of hepatic excretion of conjugated bilirubin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4975449</pmid><doi>10.1016/S0002-9378(16)34445-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1969-04, Vol.103 (7), p.950-958 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amniotic Fluid - analysis Animals Bile - analysis Bilirubin - metabolism Carbon Isotopes Female Fetus - analysis Haplorhini Liver - metabolism Maternal-Fetal Exchange Metabolic Clearance Rate Placenta - physiology Pregnancy Pregnancy, Animal |
| title | Placental transfer and disposition of bilirubin in the pregnant monkey |
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