Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors
In general, preweanling and adult rats respond similarly when challenged with competitive dopamine (DA) agonists or antagonists. In contrast, results using a noncompetitive antagonist suggest that the D1 and D2 receptor systems of preweanling and adult rats differ in some critical way. To further as...
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| Veröffentlicht in: | Psychopharmacologia 1993-05, Vol.111 (2), p.225-232 |
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| creator | MCDOUGALL, S. A CRAWFORD, C. A NONNEMAN, A. J |
| description | In general, preweanling and adult rats respond similarly when challenged with competitive dopamine (DA) agonists or antagonists. In contrast, results using a noncompetitive antagonist suggest that the D1 and D2 receptor systems of preweanling and adult rats differ in some critical way. To further assess this phenomenon, the behavioral effects of irreversible receptor blockade were assessed across 8 days in NPA (a nonselective DA agonist), quinpirole (a D2 agonist), or SKF 38393 (a D1 agonist) treated 17-day-old rat pups. The irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) did not block the locomotor activity and rearing of NPA- or quinpirole-treated rat pups, nor did EEDQ reduce SKF 38393-induced grooming. Moreover, pretreatment with EEDQ appeared to potentiate the normal increases in locomotor activity and rearing produced by NPA, but only when D2 receptors were not protected by a previous injection of sulpiride (a D2 antagonist). Taken together, these results are consistent with the presence of large reserves of D1 and D2 receptors in the preweanling rat pup. |
| doi_str_mv | 10.1007/BF02245528 |
| format | Article |
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Moreover, pretreatment with EEDQ appeared to potentiate the normal increases in locomotor activity and rearing produced by NPA, but only when D2 receptors were not protected by a previous injection of sulpiride (a D2 antagonist). 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Drug treatments ; Quinolines - pharmacology ; Quinpirole ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1 - agonists ; Receptors, Dopamine D1 - antagonists & inhibitors ; Receptors, Dopamine D2 - agonists ; Sulpiride - pharmacology</subject><ispartof>Psychopharmacologia, 1993-05, Vol.111 (2), p.225-232</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-94a889d9480b09be47e5ee93405ed1b7b4b2215422c3b3af61c6a6299c510b473</citedby><cites>FETCH-LOGICAL-c226t-94a889d9480b09be47e5ee93405ed1b7b4b2215422c3b3af61c6a6299c510b473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4760290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7870957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCDOUGALL, S. A</creatorcontrib><creatorcontrib>CRAWFORD, C. A</creatorcontrib><creatorcontrib>NONNEMAN, A. J</creatorcontrib><title>Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>In general, preweanling and adult rats respond similarly when challenged with competitive dopamine (DA) agonists or antagonists. In contrast, results using a noncompetitive antagonist suggest that the D1 and D2 receptor systems of preweanling and adult rats differ in some critical way. To further assess this phenomenon, the behavioral effects of irreversible receptor blockade were assessed across 8 days in NPA (a nonselective DA agonist), quinpirole (a D2 agonist), or SKF 38393 (a D1 agonist) treated 17-day-old rat pups. The irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) did not block the locomotor activity and rearing of NPA- or quinpirole-treated rat pups, nor did EEDQ reduce SKF 38393-induced grooming. Moreover, pretreatment with EEDQ appeared to potentiate the normal increases in locomotor activity and rearing produced by NPA, but only when D2 receptors were not protected by a previous injection of sulpiride (a D2 antagonist). Taken together, these results are consistent with the presence of large reserves of D1 and D2 receptors in the preweanling rat pup.</description><subject>Aging - psychology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Benzazepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Ergolines - pharmacology</subject><subject>Female</subject><subject>Grooming - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinolines - pharmacology</subject><subject>Quinpirole</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D1 - agonists</subject><subject>Receptors, Dopamine D1 - antagonists & inhibitors</subject><subject>Receptors, Dopamine D2 - agonists</subject><subject>Sulpiride - pharmacology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAURS0EglJY2JE8IAakUH8ljkcon1IlFpgj23kBo8Qudlqp_4CfTaJW9C1-z_foDBehC0puKSFydv9EGBN5zsoDNKGCs4wRyQ7RhBDOM07z8gSdpvRNhhGlOEbHspRE5XKCfu_hS69diLrF0DRg-4RDgxO0w-rWgLWvsQ9-_1GHpe6cH5LP4F0aeY83YeU_cdTDpZseInYxwhpicqYdHf0W7kb3Ax2lsxDxA8MRLCz7ENMZOmp0m-B8907Rx9Pj-_wlW7w9v87vFpllrOgzJXRZqlqJkhiiDAgJOYDiguRQUyONMIzRXDBmueG6KagtdMGUsjklRkg-Rddb7zKGnxWkvupcstC22kNYpUoWnHJesAG82YI2hpQiNNUyuk7HTUVJNdZe7Wsf4MuddWU6qP_RXc9DfrXLdbK6baL21qV_TMiCMEX4HyrAiqY</recordid><startdate>199305</startdate><enddate>199305</enddate><creator>MCDOUGALL, S. A</creator><creator>CRAWFORD, C. A</creator><creator>NONNEMAN, A. J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199305</creationdate><title>Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors</title><author>MCDOUGALL, S. A ; CRAWFORD, C. A ; NONNEMAN, A. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-94a889d9480b09be47e5ee93405ed1b7b4b2215422c3b3af61c6a6299c510b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aging - psychology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Benzazepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Ergolines - pharmacology</topic><topic>Female</topic><topic>Grooming - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinolines - pharmacology</topic><topic>Quinpirole</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Dopamine D1 - agonists</topic><topic>Receptors, Dopamine D1 - antagonists & inhibitors</topic><topic>Receptors, Dopamine D2 - agonists</topic><topic>Sulpiride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCDOUGALL, S. A</creatorcontrib><creatorcontrib>CRAWFORD, C. A</creatorcontrib><creatorcontrib>NONNEMAN, A. 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To further assess this phenomenon, the behavioral effects of irreversible receptor blockade were assessed across 8 days in NPA (a nonselective DA agonist), quinpirole (a D2 agonist), or SKF 38393 (a D1 agonist) treated 17-day-old rat pups. The irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) did not block the locomotor activity and rearing of NPA- or quinpirole-treated rat pups, nor did EEDQ reduce SKF 38393-induced grooming. Moreover, pretreatment with EEDQ appeared to potentiate the normal increases in locomotor activity and rearing produced by NPA, but only when D2 receptors were not protected by a previous injection of sulpiride (a D2 antagonist). Taken together, these results are consistent with the presence of large reserves of D1 and D2 receptors in the preweanling rat pup.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7870957</pmid><doi>10.1007/BF02245528</doi><tpages>8</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 1993-05, Vol.111 (2), p.225-232 |
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| subjects | Aging - psychology Animals Behavior, Animal - drug effects Benzazepines - pharmacology Biological and medical sciences Catecholaminergic system Dopamine D2 Receptor Antagonists Ergolines - pharmacology Female Grooming - drug effects Male Medical sciences Motor Activity - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Quinolines - pharmacology Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D2 - agonists Sulpiride - pharmacology |
| title | Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors |
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