Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats
Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effec...
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| Veröffentlicht in: | Neuroscience and behavioral physiology 1985-05, Vol.15 (3), p.240-246 |
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| container_title | Neuroscience and behavioral physiology |
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| creator | Medvedev, V I Bakharev, V D Kaurov, O A |
| description | Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin. |
| doi_str_mv | 10.1007/BF01182994 |
| format | Article |
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They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.</description><identifier>ISSN: 0097-0549</identifier><identifier>EISSN: 1573-899X</identifier><identifier>DOI: 10.1007/BF01182994</identifier><identifier>PMID: 2863780</identifier><language>eng</language><publisher>United States</publisher><subject>adrenocorticotropic hormone ; Adrenocorticotropic Hormone - pharmacology ; Amnesia - drug therapy ; Animals ; Arginine Vasopressin - pharmacology ; Avoidance Learning - drug effects ; enkephalin, leucine ; Enkephalin, Leucine - pharmacology ; ESB ; Humans ; long term memory ; Memory - drug effects ; MSH Release-Inhibiting Hormone - analogs & derivatives ; MSH Release-Inhibiting Hormone - pharmacology ; Oxytocin - analogs & derivatives ; Oxytocin - pharmacology ; Peptide Fragments - pharmacology ; Peptides - pharmacology ; Rats ; vasopressin, arginine</subject><ispartof>Neuroscience and behavioral physiology, 1985-05, Vol.15 (3), p.240-246</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c187t-33cd55a6838a168e22ec9cbcde570ddb0c150a8131fc87aacbd25f9b0b76a2bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2863780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Medvedev, V I</creatorcontrib><creatorcontrib>Bakharev, V D</creatorcontrib><creatorcontrib>Kaurov, O A</creatorcontrib><title>Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats</title><title>Neuroscience and behavioral physiology</title><addtitle>Neurosci Behav Physiol</addtitle><description>Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.</description><subject>adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Amnesia - drug therapy</subject><subject>Animals</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>Avoidance Learning - drug effects</subject><subject>enkephalin, leucine</subject><subject>Enkephalin, Leucine - pharmacology</subject><subject>ESB</subject><subject>Humans</subject><subject>long term memory</subject><subject>Memory - drug effects</subject><subject>MSH Release-Inhibiting Hormone - analogs & derivatives</subject><subject>MSH Release-Inhibiting Hormone - pharmacology</subject><subject>Oxytocin - analogs & derivatives</subject><subject>Oxytocin - pharmacology</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptides - pharmacology</subject><subject>Rats</subject><subject>vasopressin, arginine</subject><issn>0097-0549</issn><issn>1573-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAURYMo4_ixcS9k5UKoJk3bJEsdHBUENwruSpq8OtG2qUmqzL83MoMuXd0H79y7OAidUHJBCeGX10tCqcilLHbQnJacZULKl100J0TyjJSF3EcHIbyRBHNBZmiWi4qla45g4fpReRXtJ2ClU9i4xq7FPfTOr7PemalL3-EVDzB5N8IYrYGAG2idT5XBYNVG8Bg60NFbjcPK6XdsB_y1shFw2g5HaK9VXYDjbR6i5-XN0-Iue3i8vV9cPWSaCh4zxrQpS1UJJhStBOQ5aKkbbaDkxJiGaFoSJSijrRZcKd2YvGxlQxpeqbwx7BCdbXZH7z4mCLHubdDQdWoAN4WaV4wUFWP_grRgoiA5T-D5BtTeheChrUdve-XXNSX1j_z6T36CT7erU9OD-UW3ttk3_DGBHg</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Medvedev, V I</creator><creator>Bakharev, V D</creator><creator>Kaurov, O A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SQ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats</title><author>Medvedev, V I ; Bakharev, V D ; Kaurov, O A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c187t-33cd55a6838a168e22ec9cbcde570ddb0c150a8131fc87aacbd25f9b0b76a2bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Amnesia - drug therapy</topic><topic>Animals</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>Avoidance Learning - drug effects</topic><topic>enkephalin, leucine</topic><topic>Enkephalin, Leucine - pharmacology</topic><topic>ESB</topic><topic>Humans</topic><topic>long term memory</topic><topic>Memory - drug effects</topic><topic>MSH Release-Inhibiting Hormone - analogs & derivatives</topic><topic>MSH Release-Inhibiting Hormone - pharmacology</topic><topic>Oxytocin - analogs & derivatives</topic><topic>Oxytocin - pharmacology</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptides - pharmacology</topic><topic>Rats</topic><topic>vasopressin, arginine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medvedev, V I</creatorcontrib><creatorcontrib>Bakharev, V D</creatorcontrib><creatorcontrib>Kaurov, O A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Endocrinology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience and behavioral physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medvedev, V I</au><au>Bakharev, V D</au><au>Kaurov, O A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats</atitle><jtitle>Neuroscience and behavioral physiology</jtitle><addtitle>Neurosci Behav Physiol</addtitle><date>1985-05</date><risdate>1985</risdate><volume>15</volume><issue>3</issue><spage>240</spage><epage>246</epage><pages>240-246</pages><issn>0097-0549</issn><eissn>1573-899X</eissn><abstract>Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.</abstract><cop>United States</cop><pmid>2863780</pmid><doi>10.1007/BF01182994</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neuroscience and behavioral physiology, 1985-05, Vol.15 (3), p.240-246 |
| issn | 0097-0549 1573-899X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology Amnesia - drug therapy Animals Arginine Vasopressin - pharmacology Avoidance Learning - drug effects enkephalin, leucine Enkephalin, Leucine - pharmacology ESB Humans long term memory Memory - drug effects MSH Release-Inhibiting Hormone - analogs & derivatives MSH Release-Inhibiting Hormone - pharmacology Oxytocin - analogs & derivatives Oxytocin - pharmacology Peptide Fragments - pharmacology Peptides - pharmacology Rats vasopressin, arginine |
| title | Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats |
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