The Effect of Dietary Protein on the Clearance of Allopurinol and Oxypurinol

A decrease in dietary protein is known to depress renal plasma flow and creatinine clearance. Using a randomized crossover design, we investigated the pharmacokinetics of allopurinol and its principal metabolite, oxypurinol, after oral administration of 600 mg of allopurinol in six normal subjects r...

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Veröffentlicht in:	The New England journal of medicine 1985-09, Vol.313 (13), p.771-776
Hauptverfasser:	Berlinger, William G, Park, Glen D, Spector, Reynold
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allopurinol Allopurinol - blood Allopurinol - metabolism Biological and medical sciences Chromatography Creatinine Diet Dietary Proteins - administration & dosage Dietary Proteins - pharmacology Diuresis Excretion General and cellular metabolism. Vitamins Half-Life High protein diet Humans Internal medicine Kidneys Kinetics Low protein diet Male Medical sciences Metabolic Clearance Rate Metabolism Metabolites Nutrient deficiency Nutrition research Oral administration Oxypurinol - blood Oxypurinol - metabolism Oxypurinol - urine Pharmacokinetics Pharmacology. Drug treatments Protein turnover Proteins Pyrimidines - metabolism Reabsorption Time Factors Uric acid Urine
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