Colorimetric Determination of Some N-1-Substituted Nitroimidazoles
A colorimetric method is presented for the determination of some N-1-substituted nitroimidazoles. The method utilizes diazotization of a sulfanilamide with the nitrite ions produced during the alkaline hydrolysis of the respective imidazole. Subsequent coupling is then carried out with Bratton-Marsh...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1969-01, Vol.58 (1), p.55-57 |
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| container_end_page | 57 |
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| container_issue | 1 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 58 |
| creator | Lau, Edward P.K. Yao, C. Lewis, M. Senkowski, B.Z. |
| description | A colorimetric method is presented for the determination of some N-1-substituted nitroimidazoles. The method utilizes diazotization of a sulfanilamide with the nitrite ions produced during the alkaline hydrolysis of the respective imidazole. Subsequent coupling is then carried out with Bratton-Marshall reagent. The sensitivity of this method of analysis is approximately 0.1 mcg./ml. This procedure can be used for the determination of one of the N-1-substituted nitroimidazoles, 1-methyl-2-isopropyl-5-nitroimidazole, in feed premixes containing multiple vitamins, and is herein presented. |
| doi_str_mv | 10.1002/jps.2600580109 |
| format | Article |
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The method utilizes diazotization of a sulfanilamide with the nitrite ions produced during the alkaline hydrolysis of the respective imidazole. Subsequent coupling is then carried out with Bratton-Marshall reagent. The sensitivity of this method of analysis is approximately 0.1 mcg./ml. This procedure can be used for the determination of one of the N-1-substituted nitroimidazoles, 1-methyl-2-isopropyl-5-nitroimidazole, in feed premixes containing multiple vitamins, and is herein presented.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600580109</identifier><identifier>PMID: 5765836</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>1-Methyl-2-isopropyl-5-nitroimidazole-determination ; 1-Methyl-2-isopropyl-5-nitroimidazole—determination, feed premix ; Animal Feed - analysis ; Bratton-Marshall reaction-analysis ; Colorimetric analysis-spectrophotometer ; Colorimetry ; feed premix ; imidazole hydrolysis ; Imidazoles - analysis ; N-1-substituted-analysis ; Nitrites ; Nitroimidazoles ; Nitroimidazoles, N-1-substituted—analysis ; Spectrophotometry ; Sulfanilamide reagent-diazotization ; Sulfanilamide reagent—diazotization, imidazole hydrolysis ; Sulfanilamides</subject><ispartof>Journal of pharmaceutical sciences, 1969-01, Vol.58 (1), p.55-57</ispartof><rights>1969 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4279-f7afce0e1b2cb1af6275828e8dcce8ccacda2e7b5efdc152c7548fc1989bd9863</citedby><cites>FETCH-LOGICAL-c4279-f7afce0e1b2cb1af6275828e8dcce8ccacda2e7b5efdc152c7548fc1989bd9863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600580109$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600580109$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5765836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lau, Edward P.K.</creatorcontrib><creatorcontrib>Yao, C.</creatorcontrib><creatorcontrib>Lewis, M.</creatorcontrib><creatorcontrib>Senkowski, B.Z.</creatorcontrib><title>Colorimetric Determination of Some N-1-Substituted Nitroimidazoles</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A colorimetric method is presented for the determination of some N-1-substituted nitroimidazoles. The method utilizes diazotization of a sulfanilamide with the nitrite ions produced during the alkaline hydrolysis of the respective imidazole. Subsequent coupling is then carried out with Bratton-Marshall reagent. The sensitivity of this method of analysis is approximately 0.1 mcg./ml. This procedure can be used for the determination of one of the N-1-substituted nitroimidazoles, 1-methyl-2-isopropyl-5-nitroimidazole, in feed premixes containing multiple vitamins, and is herein presented.</description><subject>1-Methyl-2-isopropyl-5-nitroimidazole-determination</subject><subject>1-Methyl-2-isopropyl-5-nitroimidazole—determination, feed premix</subject><subject>Animal Feed - analysis</subject><subject>Bratton-Marshall reaction-analysis</subject><subject>Colorimetric analysis-spectrophotometer</subject><subject>Colorimetry</subject><subject>feed premix</subject><subject>imidazole hydrolysis</subject><subject>Imidazoles - analysis</subject><subject>N-1-substituted-analysis</subject><subject>Nitrites</subject><subject>Nitroimidazoles</subject><subject>Nitroimidazoles, N-1-substituted—analysis</subject><subject>Spectrophotometry</subject><subject>Sulfanilamide reagent-diazotization</subject><subject>Sulfanilamide reagent—diazotization, imidazole hydrolysis</subject><subject>Sulfanilamides</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAURS0EaofCtrtKWbHLYDvjjyzLQFtgNCCmVbuznOcXyW0yHmwHWn49qTIqYoFYvcU790r3EHLM6JxRyt_e7tKcS0qFpozWz8iMCU5LSZl6TmYjwMtKLOpD8jKlW0qppEIckAOhpNCVnJF3y9CF6HvM0UPxHjPG3m9t9mFbhLbYhB6LdcnKzdCk7POQ0RVrn2PwvXf2V-gwvSIvWtslfL2_R-Tq7MPl8qJcfTn_uDxdlbDgqi5bZVtAiqzh0DDbSq6E5hq1A0ANYMFZjqoR2DoYR4ASC90Cq3XduFrL6oi8mXp3MXwfMGXT-wTYdXaLYUhGyYoyIR_B-QRCDClFbM1uXGjjg2HUPEozozTzR9oYONk3D02P7gnfWxr_9fT_6Tt8-E-b-fR181d3OWV9ynj_lLXxzkhVKWGu1-fm5vPqmmn5zZyNvJ54HFX-8BhNAo9bQOcjQjYu-H_N-A12QpvJ</recordid><startdate>196901</startdate><enddate>196901</enddate><creator>Lau, Edward P.K.</creator><creator>Yao, C.</creator><creator>Lewis, M.</creator><creator>Senkowski, B.Z.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196901</creationdate><title>Colorimetric Determination of Some N-1-Substituted Nitroimidazoles</title><author>Lau, Edward P.K. ; Yao, C. ; Lewis, M. ; Senkowski, B.Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4279-f7afce0e1b2cb1af6275828e8dcce8ccacda2e7b5efdc152c7548fc1989bd9863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>1-Methyl-2-isopropyl-5-nitroimidazole-determination</topic><topic>1-Methyl-2-isopropyl-5-nitroimidazole—determination, feed premix</topic><topic>Animal Feed - analysis</topic><topic>Bratton-Marshall reaction-analysis</topic><topic>Colorimetric analysis-spectrophotometer</topic><topic>Colorimetry</topic><topic>feed premix</topic><topic>imidazole hydrolysis</topic><topic>Imidazoles - analysis</topic><topic>N-1-substituted-analysis</topic><topic>Nitrites</topic><topic>Nitroimidazoles</topic><topic>Nitroimidazoles, N-1-substituted—analysis</topic><topic>Spectrophotometry</topic><topic>Sulfanilamide reagent-diazotization</topic><topic>Sulfanilamide reagent—diazotization, imidazole hydrolysis</topic><topic>Sulfanilamides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lau, Edward P.K.</creatorcontrib><creatorcontrib>Yao, C.</creatorcontrib><creatorcontrib>Lewis, M.</creatorcontrib><creatorcontrib>Senkowski, B.Z.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lau, Edward P.K.</au><au>Yao, C.</au><au>Lewis, M.</au><au>Senkowski, B.Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colorimetric Determination of Some N-1-Substituted Nitroimidazoles</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1969-01</date><risdate>1969</risdate><volume>58</volume><issue>1</issue><spage>55</spage><epage>57</epage><pages>55-57</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A colorimetric method is presented for the determination of some N-1-substituted nitroimidazoles. The method utilizes diazotization of a sulfanilamide with the nitrite ions produced during the alkaline hydrolysis of the respective imidazole. Subsequent coupling is then carried out with Bratton-Marshall reagent. The sensitivity of this method of analysis is approximately 0.1 mcg./ml. This procedure can be used for the determination of one of the N-1-substituted nitroimidazoles, 1-methyl-2-isopropyl-5-nitroimidazole, in feed premixes containing multiple vitamins, and is herein presented.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5765836</pmid><doi>10.1002/jps.2600580109</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1969-01, Vol.58 (1), p.55-57 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76301566 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 1-Methyl-2-isopropyl-5-nitroimidazole-determination 1-Methyl-2-isopropyl-5-nitroimidazole—determination, feed premix Animal Feed - analysis Bratton-Marshall reaction-analysis Colorimetric analysis-spectrophotometer Colorimetry feed premix imidazole hydrolysis Imidazoles - analysis N-1-substituted-analysis Nitrites Nitroimidazoles Nitroimidazoles, N-1-substituted—analysis Spectrophotometry Sulfanilamide reagent-diazotization Sulfanilamide reagent—diazotization, imidazole hydrolysis Sulfanilamides |
| title | Colorimetric Determination of Some N-1-Substituted Nitroimidazoles |
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