Response of Hyperplastic Alveolar Nodule Outgrowth-Line D1 to Mammary Tumor Virus, Nodule-Inducing Virus, and Prolonged Hormonal Stimulation Acting Singly and in Combination
This paper presents evidence that the nodule-inducing virus (NIV) can participate in the production of neoplastic cell variants within the hyperplastic alveolar nodules in the mammary glands of BALB/c mice. The transplanted D1 nodule outgrowth had an increased tumor incidence and a decreased mean ag...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1969-02, Vol.42 (2), p.303-310 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Medina, Daniel DeOme, K. B. |
| description | This paper presents evidence that the nodule-inducing virus (NIV) can participate in the production of neoplastic cell variants within the hyperplastic alveolar nodules in the mammary glands of BALB/c mice. The transplanted D1 nodule outgrowth had an increased tumor incidence and a decreased mean age of onset after infection with NIV. An additional increase in tumor incidence was achieved when D1 nodule outgrowths were infected with both NIV and the mammary tumor virus (MTV). Although prolonged hormonal stimulation produced by pituitary isografts, in the absence of MTV and NIV infection, failed to increase the tumor incidence in D1 nodule outgrowth, it exerted a synergistic effect when acting in conjunction with either MTV or NIV. |
| doi_str_mv | 10.1093/jnci/42.2.303 |
| format | Article |
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B.</creatorcontrib><title>Response of Hyperplastic Alveolar Nodule Outgrowth-Line D1 to Mammary Tumor Virus, Nodule-Inducing Virus, and Prolonged Hormonal Stimulation Acting Singly and in Combination</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>This paper presents evidence that the nodule-inducing virus (NIV) can participate in the production of neoplastic cell variants within the hyperplastic alveolar nodules in the mammary glands of BALB/c mice. The transplanted D1 nodule outgrowth had an increased tumor incidence and a decreased mean age of onset after infection with NIV. An additional increase in tumor incidence was achieved when D1 nodule outgrowths were infected with both NIV and the mammary tumor virus (MTV). Although prolonged hormonal stimulation produced by pituitary isografts, in the absence of MTV and NIV infection, failed to increase the tumor incidence in D1 nodule outgrowth, it exerted a synergistic effect when acting in conjunction with either MTV or NIV.</description><subject>Animals</subject><subject>Cell Transformation, Neoplastic</subject><subject>Female</subject><subject>Mammary Neoplasms, Experimental - etiology</subject><subject>Mammary Tumor Virus, Mouse - pathogenicity</subject><subject>Mice</subject><subject>Neoplasm Transplantation</subject><subject>Pituitary Gland - transplantation</subject><subject>Pituitary Hormones, Anterior - physiology</subject><subject>Precancerous Conditions - pathology</subject><subject>Prolactin - secretion</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1v1DAQhi0EKkvhyBHJJ05k69iOnRxXy8cWbSnQgqpeIjuZLC6OHfwB7I_iP5K2C3OYkeZ935HmQeh5SZYladjJjevMCadLumSEPUCLkgtS0JJUD9GCECqLupb8MXoS4w2Zq6H8CB3x2VvXdIH-fIY4eRcB-wFv9hOEyaqYTIdX9id4qwL-4PtsAZ_ntAv-V_pWbI0D_LrEyeMzNY4q7PFlHn3AX03I8dUhUJy6PnfG7f6tlevxx-Ctdzvo8caH0Ttl8UUyY7YqGe_wqku3gYu52f1dwDi89qM27s7wFD0alI3w7DCP0Ze3by7Xm2J7_u50vdoWhnKeikp3ohQgGGsIlz0ZykELLQYm5685BS5JUzXDwDXXg6A11QI41ZJD1cz0gB2jl_d3p-B_ZIipHU3swFrlwOfYSkGbGSSdjS8OxqxH6NspmFse7YHvrBf3uokJfv-XVfjeCslk1W6urtuzNWmu3n-6bkv2F9fqji4</recordid><startdate>196902</startdate><enddate>196902</enddate><creator>Medina, Daniel</creator><creator>DeOme, K. 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B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i244t-5bc616e6339047d0f1fb6b6f3703842e470959ff4b4bf6282b6e42b74e59460e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Cell Transformation, Neoplastic</topic><topic>Female</topic><topic>Mammary Neoplasms, Experimental - etiology</topic><topic>Mammary Tumor Virus, Mouse - pathogenicity</topic><topic>Mice</topic><topic>Neoplasm Transplantation</topic><topic>Pituitary Gland - transplantation</topic><topic>Pituitary Hormones, Anterior - physiology</topic><topic>Precancerous Conditions - pathology</topic><topic>Prolactin - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medina, Daniel</creatorcontrib><creatorcontrib>DeOme, K. B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medina, Daniel</au><au>DeOme, K. 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An additional increase in tumor incidence was achieved when D1 nodule outgrowths were infected with both NIV and the mammary tumor virus (MTV). Although prolonged hormonal stimulation produced by pituitary isografts, in the absence of MTV and NIV infection, failed to increase the tumor incidence in D1 nodule outgrowth, it exerted a synergistic effect when acting in conjunction with either MTV or NIV.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>4303882</pmid><doi>10.1093/jnci/42.2.303</doi><tpages>8</tpages></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 1969-02, Vol.42 (2), p.303-310 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76299242 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Cell Transformation, Neoplastic Female Mammary Neoplasms, Experimental - etiology Mammary Tumor Virus, Mouse - pathogenicity Mice Neoplasm Transplantation Pituitary Gland - transplantation Pituitary Hormones, Anterior - physiology Precancerous Conditions - pathology Prolactin - secretion |
| title | Response of Hyperplastic Alveolar Nodule Outgrowth-Line D1 to Mammary Tumor Virus, Nodule-Inducing Virus, and Prolonged Hormonal Stimulation Acting Singly and in Combination |
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