Multiple malignancy in the upper genital canal

The concomitant finding of multiple sites of malignant alteration in the upper genital canal (fundus, tube, and ovary) is a frequent and historically well-documented occurrence. Among the study group, there were 118 secondary carcinomas in the Fallopian tube, and 397 cases classified as primary ovarian, endometrial, or tubal cancers. Study revealed that in numerous instances, the pattern of the neoplasm in the separate organs was similar enough to make determination of the primary site impossible and to suggest that a proportion of these cases represented multicentric foci of origin rather than metastatic disease.