Potential Epidemic of Creutzfeldt–Jakob Disease from Human Growth Hormone Therapy
A DECADE after the demonstration that Creutzfeldt—Jakob disease could be accidentally transmitted from one person to another during brain or eye surgery, 1 , 2 iatrogenic Creutzfeldt—Jakob disease has reappeared as a result of earlier therapy with human growth hormone, with the ominous possibility o...
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| Veröffentlicht in: | The New England journal of medicine 1985-09, Vol.313 (12), p.728-731 |
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| container_title | The New England journal of medicine |
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| creator | Brown, Paul Gajdusek, D. Carleton Gibbs, C.J Asher, David M |
| description | A DECADE after the demonstration that Creutzfeldt—Jakob disease could be accidentally transmitted from one person to another during brain or eye surgery,
1
,
2
iatrogenic Creutzfeldt—Jakob disease has reappeared as a result of earlier therapy with human growth hormone, with the ominous possibility of a burgeoning epidemic.
Within just a few months, three young adults in the United States have died from the disease, confirmed neuropathologically in two patients and clinically detected but unconfirmed in one
3
; an additional neuropathologically confirmed case has been identified in Great Britain.
4
Salient data on these four cases are summarized in Table 1. (The details of both . . . |
| doi_str_mv | 10.1056/NEJM198509193131205 |
| format | Article |
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1
,
2
iatrogenic Creutzfeldt—Jakob disease has reappeared as a result of earlier therapy with human growth hormone, with the ominous possibility of a burgeoning epidemic.
Within just a few months, three young adults in the United States have died from the disease, confirmed neuropathologically in two patients and clinically detected but unconfirmed in one
3
; an additional neuropathologically confirmed case has been identified in Great Britain.
4
Salient data on these four cases are summarized in Table 1. (The details of both . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198509193131205</identifier><identifier>PMID: 3929089</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Biological and medical sciences ; Chronic illnesses ; Creutzfeldt-Jakob disease ; Creutzfeldt-Jakob Syndrome - epidemiology ; Creutzfeldt-Jakob Syndrome - transmission ; Disease Outbreaks - epidemiology ; Drug Contamination ; Endocrine therapy ; Female ; Growth Hormone - therapeutic use ; Growth hormones ; Hormone replacement therapy ; Human viral diseases ; Humans ; Hypoglycemia ; Infectious diseases ; Male ; Medical sciences ; Mortality ; Pituitary Gland - microbiology ; Prions - pathogenicity ; Viral diseases ; Viral diseases of the nervous system ; Viruses ; Young adults</subject><ispartof>The New England journal of medicine, 1985-09, Vol.313 (12), p.728-731</ispartof><rights>1985 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Sep 19, 1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-5bcb10a4f07842b017ebffd30feb421d14d9ee6dbd487c4989c987d59cd313843</citedby><cites>FETCH-LOGICAL-c393t-5bcb10a4f07842b017ebffd30feb421d14d9ee6dbd487c4989c987d59cd313843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1878197714?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9285611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3929089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Paul</creatorcontrib><creatorcontrib>Gajdusek, D. Carleton</creatorcontrib><creatorcontrib>Gibbs, C.J</creatorcontrib><creatorcontrib>Asher, David M</creatorcontrib><title>Potential Epidemic of Creutzfeldt–Jakob Disease from Human Growth Hormone Therapy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>A DECADE after the demonstration that Creutzfeldt—Jakob disease could be accidentally transmitted from one person to another during brain or eye surgery,
1
,
2
iatrogenic Creutzfeldt—Jakob disease has reappeared as a result of earlier therapy with human growth hormone, with the ominous possibility of a burgeoning epidemic.
Within just a few months, three young adults in the United States have died from the disease, confirmed neuropathologically in two patients and clinically detected but unconfirmed in one
3
; an additional neuropathologically confirmed case has been identified in Great Britain.
4
Salient data on these four cases are summarized in Table 1. (The details of both . . .</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic illnesses</subject><subject>Creutzfeldt-Jakob disease</subject><subject>Creutzfeldt-Jakob Syndrome - epidemiology</subject><subject>Creutzfeldt-Jakob Syndrome - transmission</subject><subject>Disease Outbreaks - epidemiology</subject><subject>Drug Contamination</subject><subject>Endocrine therapy</subject><subject>Female</subject><subject>Growth Hormone - therapeutic use</subject><subject>Growth hormones</subject><subject>Hormone replacement therapy</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Pituitary Gland - microbiology</subject><subject>Prions - pathogenicity</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><subject>Viruses</subject><subject>Young adults</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kM9u1DAQxq0KVJbCEyAkS0VcUMATO7F9RMvSpeo_ifYcOfZYzTaOFzsRKifegTfkSUi1qx4QYi5zmN_3zcxHyCtg74FV9YeL1ek5aFUxDZoDh5JVB2QBFeeFEKx-QhaMlaoQUvNn5HnOGzYXCH1IDrkuNVN6Qb5exRGHsTM9XW07h6GzNHq6TDiNPzz2bvz989epuYst_dRlNBmpTzHQ9RTMQE9S_D7e0nVMIQ5Ir28xme39C_LUmz7jy30_IjefV9fLdXF2efJl-fGssFzzsaha2wIzwjOpRNkykNh67zjz2IoSHAinEWvXOqGkFVppq5V0lbZu_lYJfkTe7ny3KX6bMI9N6LLFvjcDxik3si51rRSfweO_wE2c0jDf1oCSCrSU8GDHd5RNMeeEvtmmLph03wBrHgJv_hH4rHq9957agO5Rs094nr_Zz022pvfJDLbLj5guVVUDzNi7HRZCbgbchP8u_QNzdpR7</recordid><startdate>19850919</startdate><enddate>19850919</enddate><creator>Brown, Paul</creator><creator>Gajdusek, D. Carleton</creator><creator>Gibbs, C.J</creator><creator>Asher, David M</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19850919</creationdate><title>Potential Epidemic of Creutzfeldt–Jakob Disease from Human Growth Hormone Therapy</title><author>Brown, Paul ; Gajdusek, D. Carleton ; Gibbs, C.J ; Asher, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-5bcb10a4f07842b017ebffd30feb421d14d9ee6dbd487c4989c987d59cd313843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic illnesses</topic><topic>Creutzfeldt-Jakob disease</topic><topic>Creutzfeldt-Jakob Syndrome - epidemiology</topic><topic>Creutzfeldt-Jakob Syndrome - transmission</topic><topic>Disease Outbreaks - epidemiology</topic><topic>Drug Contamination</topic><topic>Endocrine therapy</topic><topic>Female</topic><topic>Growth Hormone - therapeutic use</topic><topic>Growth hormones</topic><topic>Hormone replacement therapy</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Pituitary Gland - microbiology</topic><topic>Prions - pathogenicity</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><topic>Viruses</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Paul</creatorcontrib><creatorcontrib>Gajdusek, D. 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Carleton</au><au>Gibbs, C.J</au><au>Asher, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Epidemic of Creutzfeldt–Jakob Disease from Human Growth Hormone Therapy</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1985-09-19</date><risdate>1985</risdate><volume>313</volume><issue>12</issue><spage>728</spage><epage>731</epage><pages>728-731</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>A DECADE after the demonstration that Creutzfeldt—Jakob disease could be accidentally transmitted from one person to another during brain or eye surgery,
1
,
2
iatrogenic Creutzfeldt—Jakob disease has reappeared as a result of earlier therapy with human growth hormone, with the ominous possibility of a burgeoning epidemic.
Within just a few months, three young adults in the United States have died from the disease, confirmed neuropathologically in two patients and clinically detected but unconfirmed in one
3
; an additional neuropathologically confirmed case has been identified in Great Britain.
4
Salient data on these four cases are summarized in Table 1. (The details of both . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>3929089</pmid><doi>10.1056/NEJM198509193131205</doi><tpages>4</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 1985-09, Vol.313 (12), p.728-731 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| subjects | Adult Biological and medical sciences Chronic illnesses Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - epidemiology Creutzfeldt-Jakob Syndrome - transmission Disease Outbreaks - epidemiology Drug Contamination Endocrine therapy Female Growth Hormone - therapeutic use Growth hormones Hormone replacement therapy Human viral diseases Humans Hypoglycemia Infectious diseases Male Medical sciences Mortality Pituitary Gland - microbiology Prions - pathogenicity Viral diseases Viral diseases of the nervous system Viruses Young adults |
| title | Potential Epidemic of Creutzfeldt–Jakob Disease from Human Growth Hormone Therapy |
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