In Vitro Transformation by an Avian Adenovirus (CELO). I. Hamster-Embryo Fibroblastic Cultures
Chicken-embryo-lethal-orphan (CELO) virus was shown to transform hamster-embryo fibroblastic cells in vitro. The first signs of infection were at 24 hours when pyramidal or stellate cell forms were observed in a disorganized growth pattern. After 4 passages fibroblastic elements gave way to epitheli...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1969-01, Vol.42 (1), p.1-7 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Anderson, Jeffrey Yates, Vance J. Jasty, V. Mancini, Lawrence O. |
| description | Chicken-embryo-lethal-orphan (CELO) virus was shown to transform hamster-embryo fibroblastic cells in vitro. The first signs of infection were at 24 hours when pyramidal or stellate cell forms were observed in a disorganized growth pattern. After 4 passages fibroblastic elements gave way to epithelioid-like cells. Virus production decreased as the number of transformed cells increased. A virus-specific intranuclear “T” antigen was observed in most cells by immunofluorescent techniques. Cells from the seventh and twelfth passages induced fibrosarcomas when inoculated subcutaneously into hamsters 3–4 weeks old. |
| doi_str_mv | 10.1093/jnci/42.1.1 |
| format | Article |
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Cells from the seventh and twelfth passages induced fibrosarcomas when inoculated subcutaneously into hamsters 3–4 weeks old.</description><subject>Adenoviridae</subject><subject>Animals</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cricetinae</subject><subject>Embryo, Mammalian</subject><subject>Fibroblasts</subject><subject>Fibrosarcoma</subject><subject>Fluorescent Antibody Technique</subject><subject>Neoplasms, Experimental</subject><subject>Oncogenic Viruses</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LwzAYh4Moc05PnoWcRA_t8tWmPY66Lyjs4BziwZK0CWS2zUza4f57Jxv-Du_v8Dy88L4A3GMUYpTS8bYtzZiREIf4Agwxi1FAMIouwRAhwoMk4ewa3Hi_RcekhA3AgCVJRAkdgs9lCzemcxaunWi9tq4RnbEtlAcoWjjZm79Zqdbujes9fMqm-eo5hMsQLkTjO-WCaSPdwcKZkc7KWvjOlDDr6653yt-CKy1qr-7OPQJvs-k6WwT5ar7MJnlgCGNdIDXRZSVIEvOS0FQhpkpJKOKMp5gzzMtKyrKKWMx0xLGmlCEUJ1RTXmmlER2Bx9PenbPfvfJd0RhfqroWrbK9L3hMUpogfBQfzmIvG1UVO2ca4Q7F-SFHHpy4Od7284-F-ypiTnlULN4_ipy8kvkLwcWG_gJMlW_2</recordid><startdate>196901</startdate><enddate>196901</enddate><creator>Anderson, Jeffrey</creator><creator>Yates, Vance J.</creator><creator>Jasty, V.</creator><creator>Mancini, Lawrence O.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196901</creationdate><title>In Vitro Transformation by an Avian Adenovirus (CELO). 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| ispartof | JNCI : Journal of the National Cancer Institute, 1969-01, Vol.42 (1), p.1-7 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adenoviridae Animals Cell Transformation, Neoplastic Cricetinae Embryo, Mammalian Fibroblasts Fibrosarcoma Fluorescent Antibody Technique Neoplasms, Experimental Oncogenic Viruses |
| title | In Vitro Transformation by an Avian Adenovirus (CELO). I. Hamster-Embryo Fibroblastic Cultures |
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