Cyclothialidine and its congeners: A new class of DNA gyrase inhibitors

Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity against intact bacterial cells. To explore its potential with regard to the development of a new type of antibacterial, a flexible synthetic route...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 1993-01, Vol.60 (2), p.367-380
Hauptverfasser:	Goetschi, E., Angehrn, P., Gmuender, H., Hebeisen, P., Link, H., Masciadri, R., Nielsen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibacterial agent(s) Bacteria - drug effects Bacteria - enzymology biological activity Cyclothialidine DNA gyrase inhibitor(s) Escherichia coli - drug effects Escherichia coli - enzymology Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Microbial Sensitivity Tests Peptides, Cyclic Pyrroles - chemistry Pyrroles - pharmacology Structure-Activity Relationship structure-activity relationships synthesis Topoisomerase II Inhibitors
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