Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia
Six women developed chronic long-term arthropathy after postpartum immunization against rubella. All individuals developed acute polyarticular arthritis within 12days to three weeks postimmunization and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vac...
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| Veröffentlicht in: | The Journal of infectious diseases 1985-09, Vol.152 (3), p.606-612 |
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| container_title | The Journal of infectious diseases |
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| creator | Tingle, Aubrey J. Chantler, Janet K. Pot, Kees H. Paty, Donald W. Ford, Denys K. |
| description | Six women developed chronic long-term arthropathy after postpartum immunization against rubella. All individuals developed acute polyarticular arthritis within 12days to three weeks postimmunization and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination. Acute neurological manifestations, consisting of carpal tunnel syndrome or multiple paresthesiae, developed postvaccination in three women. Two have developed continuing active or chronic recurrent episodes of blurred vision, paresthesiae, and painful limb syndromes together with recurrent joint symptoms. Chronic rubella viremia has been detected in peripheral blood mononuclear cell (MNC) populations in five of the six women up to six years after vaccination. In addition rubella virus was isolated from breast milk MNCs in one individual at nine months postvaccination and from peripheral blood MNCs in two of four breast-fed infants studied at 12–18 months of age. Immune responses to rubella virus studied at sequential intervals after vaccination correlated with development of rheumatologic and neurological manifestations. |
| doi_str_mv | 10.1093/infdis/152.3.606 |
| format | Article |
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All individuals developed acute polyarticular arthritis within 12days to three weeks postimmunization and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination. Acute neurological manifestations, consisting of carpal tunnel syndrome or multiple paresthesiae, developed postvaccination in three women. Two have developed continuing active or chronic recurrent episodes of blurred vision, paresthesiae, and painful limb syndromes together with recurrent joint symptoms. Chronic rubella viremia has been detected in peripheral blood mononuclear cell (MNC) populations in five of the six women up to six years after vaccination. In addition rubella virus was isolated from breast milk MNCs in one individual at nine months postvaccination and from peripheral blood MNCs in two of four breast-fed infants studied at 12–18 months of age. Immune responses to rubella virus studied at sequential intervals after vaccination correlated with development of rheumatologic and neurological manifestations.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/152.3.606</identifier><identifier>PMID: 4031558</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Antibodies, Viral - analysis ; Arthralgia ; Arthritis ; Arthritis - etiology ; Biological and medical sciences ; Blood ; Carpal tunnel syndrome ; Carpal Tunnel Syndrome - etiology ; Child ; Child, Preschool ; Children ; Female ; Human viral diseases ; Humans ; Immunization ; Infant ; Infant, Newborn ; Infectious diseases ; Lymphocyte Activation ; Medical sciences ; Milk, Human - microbiology ; Monocytes - microbiology ; Nervous System Diseases - etiology ; Original Articles ; Paresthesia - etiology ; Postpartum Period ; Pregnancy ; Rubella ; Rubella - etiology ; Rubella - transmission ; Rubella Vaccine - adverse effects ; Rubella vaccines ; Rubella virus ; Rubella virus - immunology ; Rubella virus - isolation & purification ; Vaccination ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye ; Viremia - etiology</subject><ispartof>The Journal of infectious diseases, 1985-09, Vol.152 (3), p.606-612</ispartof><rights>Copyright 1985 The University of Chicago</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-12914075504e0598738cdf22a5fb933194484feaa5663613f608c6e5398c244c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30105319$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30105319$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8602128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4031558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tingle, Aubrey J.</creatorcontrib><creatorcontrib>Chantler, Janet K.</creatorcontrib><creatorcontrib>Pot, Kees H.</creatorcontrib><creatorcontrib>Paty, Donald W.</creatorcontrib><creatorcontrib>Ford, Denys K.</creatorcontrib><title>Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Six women developed chronic long-term arthropathy after postpartum immunization against rubella. All individuals developed acute polyarticular arthritis within 12days to three weeks postimmunization and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination. Acute neurological manifestations, consisting of carpal tunnel syndrome or multiple paresthesiae, developed postvaccination in three women. Two have developed continuing active or chronic recurrent episodes of blurred vision, paresthesiae, and painful limb syndromes together with recurrent joint symptoms. Chronic rubella viremia has been detected in peripheral blood mononuclear cell (MNC) populations in five of the six women up to six years after vaccination. In addition rubella virus was isolated from breast milk MNCs in one individual at nine months postvaccination and from peripheral blood MNCs in two of four breast-fed infants studied at 12–18 months of age. Immune responses to rubella virus studied at sequential intervals after vaccination correlated with development of rheumatologic and neurological manifestations.</description><subject>Adult</subject><subject>Antibodies, Viral - analysis</subject><subject>Arthralgia</subject><subject>Arthritis</subject><subject>Arthritis - etiology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Carpal tunnel syndrome</subject><subject>Carpal Tunnel Syndrome - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Female</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Lymphocyte Activation</subject><subject>Medical sciences</subject><subject>Milk, Human - microbiology</subject><subject>Monocytes - microbiology</subject><subject>Nervous System Diseases - etiology</subject><subject>Original Articles</subject><subject>Paresthesia - etiology</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Rubella</subject><subject>Rubella - etiology</subject><subject>Rubella - transmission</subject><subject>Rubella Vaccine - adverse effects</subject><subject>Rubella vaccines</subject><subject>Rubella virus</subject><subject>Rubella virus - immunology</subject><subject>Rubella virus - isolation & purification</subject><subject>Vaccination</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><subject>Viremia - etiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0EKqGwZ4PkBWLVSf0eD7sQoK1USnlViI3leOzG7cw42B4K_IL-7DokhCUr6_o799yrewB4itEUo4Ye-sG1Ph1iTqZ0KpC4ByaY07oSAtP7YIIQIRWWTfMQPErpCiHEqKj3wB5DFHMuJ-D2PKS80jGPPfw4LmzXaXjS9-Pgf-vsw_ASzlIKxv8p4I3PS_ja_rBdWPV2yDA4eB5DF4ZL28JZzMvos08H8MyO6-9Lb3QHP9nvo-20PYB6aOF8GcPgzW7ahY-29_oxeOB0l-yT7bsPvrx983l-XJ2-PzqZz04rwzDLFSYNZqjmHDGLeCNrKk3rCNHcLRpKccOYZM5qzYWg5QhOIGmE5bSRhjBm6D54sfFdxVDWSln1Ppn1JoMNY1K1IFKKmvxXiFmZJoUsQrQRmhhSitapVfS9jr8URmqdktqkpEpKiqqSUml5tvUeF71tdw3bWAp_vuU6lQu6qAdTDP7KpEAEE_nP5irlEHeYIox4Wa7wasN9yvbnjut4rURNa66Ov35T_ELUH87eNeoVvQP1J7U_</recordid><startdate>19850901</startdate><enddate>19850901</enddate><creator>Tingle, Aubrey J.</creator><creator>Chantler, Janet K.</creator><creator>Pot, Kees H.</creator><creator>Paty, Donald W.</creator><creator>Ford, Denys K.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850901</creationdate><title>Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia</title><author>Tingle, Aubrey J. ; Chantler, Janet K. ; Pot, Kees H. ; Paty, Donald W. ; Ford, Denys K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-12914075504e0598738cdf22a5fb933194484feaa5663613f608c6e5398c244c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Antibodies, Viral - analysis</topic><topic>Arthralgia</topic><topic>Arthritis</topic><topic>Arthritis - etiology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Carpal tunnel syndrome</topic><topic>Carpal Tunnel Syndrome - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Female</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Lymphocyte Activation</topic><topic>Medical sciences</topic><topic>Milk, Human - microbiology</topic><topic>Monocytes - microbiology</topic><topic>Nervous System Diseases - etiology</topic><topic>Original Articles</topic><topic>Paresthesia - etiology</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Rubella</topic><topic>Rubella - etiology</topic><topic>Rubella - transmission</topic><topic>Rubella Vaccine - adverse effects</topic><topic>Rubella vaccines</topic><topic>Rubella virus</topic><topic>Rubella virus - immunology</topic><topic>Rubella virus - isolation & purification</topic><topic>Vaccination</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><topic>Viremia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tingle, Aubrey J.</creatorcontrib><creatorcontrib>Chantler, Janet K.</creatorcontrib><creatorcontrib>Pot, Kees H.</creatorcontrib><creatorcontrib>Paty, Donald W.</creatorcontrib><creatorcontrib>Ford, Denys K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tingle, Aubrey J.</au><au>Chantler, Janet K.</au><au>Pot, Kees H.</au><au>Paty, Donald W.</au><au>Ford, Denys K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1985-09-01</date><risdate>1985</risdate><volume>152</volume><issue>3</issue><spage>606</spage><epage>612</epage><pages>606-612</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Six women developed chronic long-term arthropathy after postpartum immunization against rubella. All individuals developed acute polyarticular arthritis within 12days to three weeks postimmunization and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination. Acute neurological manifestations, consisting of carpal tunnel syndrome or multiple paresthesiae, developed postvaccination in three women. Two have developed continuing active or chronic recurrent episodes of blurred vision, paresthesiae, and painful limb syndromes together with recurrent joint symptoms. Chronic rubella viremia has been detected in peripheral blood mononuclear cell (MNC) populations in five of the six women up to six years after vaccination. In addition rubella virus was isolated from breast milk MNCs in one individual at nine months postvaccination and from peripheral blood MNCs in two of four breast-fed infants studied at 12–18 months of age. Immune responses to rubella virus studied at sequential intervals after vaccination correlated with development of rheumatologic and neurological manifestations.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>4031558</pmid><doi>10.1093/infdis/152.3.606</doi><tpages>7</tpages></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Antibodies, Viral - analysis Arthralgia Arthritis Arthritis - etiology Biological and medical sciences Blood Carpal tunnel syndrome Carpal Tunnel Syndrome - etiology Child Child, Preschool Children Female Human viral diseases Humans Immunization Infant Infant, Newborn Infectious diseases Lymphocyte Activation Medical sciences Milk, Human - microbiology Monocytes - microbiology Nervous System Diseases - etiology Original Articles Paresthesia - etiology Postpartum Period Pregnancy Rubella Rubella - etiology Rubella - transmission Rubella Vaccine - adverse effects Rubella vaccines Rubella virus Rubella virus - immunology Rubella virus - isolation & purification Vaccination Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Viremia - etiology |
| title | Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia |
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