Cytotoxicity of Cisplatin and Cisdiammine-1,1-cyclobutane Dicarboxylate in MGH-U1 Cells Grown as Monolayers, Spheroids, and Xenografts

The cytotoxicity of cisplatin and cisdiammine-1,1-cyclobutane dicarboxylate (CBDCA) was examined using the MGH-U1 human bladder carcinoma cell line, grown as monolayer cultures, multicellular tumor spheroid(s) (MTS), and xenografts in immune-deprived CBA/CaJ mice. The cell survival of exponentially...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1985-09, Vol.75 (3), p.499-505
Hauptverfasser:	Erlichman, Charles, Vidgen, Danka, Wu, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Carboplatin Cell Survival - drug effects Cells, Cultured Cisplatin - pharmacology Cytological Techniques General aspects Humans Male Medical sciences Mice Mice, Inbred CBA Organoplatinum Compounds - pharmacology Pharmacology. Drug treatments Rats Transplantation, Heterologous Urinary Bladder Neoplasms - pathology
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