Preparation of biologically active ristocetin derivatives: replacements of the 1'-amino group

A series of ristocetin analogues with modifications (OH, C=O, C=NOH, NCOCH3) at the C-1' amino group was synthesized and found to possess antibacterial activity against gram-positive bacteria and to bind to Ac2-Lys-D-Ala-D-Ala, a model for the antibiotic's site of action. Due to the lack o...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-09, Vol.28 (9), p.1371-1375
Hauptverfasser:	Herrin, Thomas R, Thomas, Alford M, Perun, Thomas J, Mao, James C, Fesik, Stephen W
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Phenomena Chemistry Exact sciences and technology Gram-Positive Bacteria - drug effects Magnetic Resonance Spectroscopy Oligopeptides - metabolism Organic chemistry Peptides Preparations and properties Ristocetin - analogs & derivatives Ristocetin - chemical synthesis Ristocetin - pharmacology Structure-Activity Relationship
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