Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate
The decomposition compound formed by xenon irradiation of nafamstat mesilate in aqueous solution and its kinetics were studied and the following findings were obtained. Nafamstat mesilate was decomposed by xenon irradiation to form 4-guanidinobenzoic acid (PGBA), 6-amino-2-naphthol (AN) and compound...
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| Veröffentlicht in: | YAKUGAKU ZASSHI 1985/05/25, Vol.105(5), pp.470-474 |
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| Sprache: | eng ; jpn |
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| container_issue | 5 |
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| container_title | YAKUGAKU ZASSHI |
| container_volume | 105 |
| creator | KUROTORI, MASAYUKI ARAKAWA, KATSUMASA SUGIYAMA, SATOSHI KURUMI, MASATERU AOYAMA, TAKUO |
| description | The decomposition compound formed by xenon irradiation of nafamstat mesilate in aqueous solution and its kinetics were studied and the following findings were obtained. Nafamstat mesilate was decomposed by xenon irradiation to form 4-guanidinobenzoic acid (PGBA), 6-amino-2-naphthol (AN) and compound II having yellow color. The structure of the compound II was studied in comparison with nafamstat mesilate by chemical and physical methods and shown to be an amide type compound of PGBA and AN. Photodemposition reaction of nafamstat mesilate was found to follow the pseudo-second order reaction. |
| doi_str_mv | 10.1248/yakushi1947.105.5_470 |
| format | Article |
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Photodemposition reaction of nafamstat mesilate was found to follow the pseudo-second order reaction.</description><identifier>ISSN: 0031-6903</identifier><identifier>EISSN: 1347-5231</identifier><identifier>DOI: 10.1248/yakushi1947.105.5_470</identifier><identifier>PMID: 4032236</identifier><language>eng ; jpn</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>4-guaninobenzoic acid ; 6-amidino-2-naphthol ; decomposition product ; Drug Stability ; Guanidines ; nafamstat mesilate ; Photolysis ; proteinase inhibitor ; Solutions ; Water</subject><ispartof>YAKUGAKU ZASSHI, 1985/05/25, Vol.105(5), pp.470-474</ispartof><rights>by the PHARMACEUTICAL SOCIETY OF JAPAN</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2640-650236256e9c0d6757dfcefe924d10be76479c74393f13e9be0d39615f267be43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4032236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUROTORI, MASAYUKI</creatorcontrib><creatorcontrib>ARAKAWA, KATSUMASA</creatorcontrib><creatorcontrib>SUGIYAMA, SATOSHI</creatorcontrib><creatorcontrib>KURUMI, MASATERU</creatorcontrib><creatorcontrib>AOYAMA, TAKUO</creatorcontrib><title>Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate</title><title>YAKUGAKU ZASSHI</title><addtitle>YAKUGAKU ZASSHI</addtitle><description>The decomposition compound formed by xenon irradiation of nafamstat mesilate in aqueous solution and its kinetics were studied and the following findings were obtained. Nafamstat mesilate was decomposed by xenon irradiation to form 4-guanidinobenzoic acid (PGBA), 6-amino-2-naphthol (AN) and compound II having yellow color. The structure of the compound II was studied in comparison with nafamstat mesilate by chemical and physical methods and shown to be an amide type compound of PGBA and AN. Photodemposition reaction of nafamstat mesilate was found to follow the pseudo-second order reaction.</description><subject>4-guaninobenzoic acid</subject><subject>6-amidino-2-naphthol</subject><subject>decomposition product</subject><subject>Drug Stability</subject><subject>Guanidines</subject><subject>nafamstat mesilate</subject><subject>Photolysis</subject><subject>proteinase inhibitor</subject><subject>Solutions</subject><subject>Water</subject><issn>0031-6903</issn><issn>1347-5231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAYRYMoOqg_QejKXWvemeJKxMeALxhdhzT96kQ7zdiki_n3RmcoIoLZBJJ7br4chE4ILgjl07O1eR_CwpGSq4JgUQjNFd5BE8K4ygVlZBdNMGYklyVmB-g4BFdhTNMSZLqP9jlmlDI5Qat5NJVrXVxn8zjUDkLmu-zBNGYZoonZPQTXmgiZ67KLjwH8ELK5b4fofFdks1nxE3ta-OjDWOibP4qO0F5j2gDH2_0QvVxfPV_e5nePN7PLi7vcUslxLgVO81EhobS4lkqourHQQEl5TXAFSnJVWsVZyRrCoKwA16yURDRUqgo4O0Snm95V79PcIeqlCxba1nRfn9BK0qlMhlJQbIK29yH00OhV75amX2uC9Zds_UN2OhP6W3biTrYPDNUS6pHaqk335796rUsikrfYG9f-2z7b0G_J3iuM7aaPzrbwBzWyY8YuTK-hY5-QlatA</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>KUROTORI, MASAYUKI</creator><creator>ARAKAWA, KATSUMASA</creator><creator>SUGIYAMA, SATOSHI</creator><creator>KURUMI, MASATERU</creator><creator>AOYAMA, TAKUO</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate</title><author>KUROTORI, MASAYUKI ; ARAKAWA, KATSUMASA ; SUGIYAMA, SATOSHI ; KURUMI, MASATERU ; AOYAMA, TAKUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2640-650236256e9c0d6757dfcefe924d10be76479c74393f13e9be0d39615f267be43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1985</creationdate><topic>4-guaninobenzoic acid</topic><topic>6-amidino-2-naphthol</topic><topic>decomposition product</topic><topic>Drug Stability</topic><topic>Guanidines</topic><topic>nafamstat mesilate</topic><topic>Photolysis</topic><topic>proteinase inhibitor</topic><topic>Solutions</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUROTORI, MASAYUKI</creatorcontrib><creatorcontrib>ARAKAWA, KATSUMASA</creatorcontrib><creatorcontrib>SUGIYAMA, SATOSHI</creatorcontrib><creatorcontrib>KURUMI, MASATERU</creatorcontrib><creatorcontrib>AOYAMA, TAKUO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>YAKUGAKU ZASSHI</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUROTORI, MASAYUKI</au><au>ARAKAWA, KATSUMASA</au><au>SUGIYAMA, SATOSHI</au><au>KURUMI, MASATERU</au><au>AOYAMA, TAKUO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate</atitle><jtitle>YAKUGAKU ZASSHI</jtitle><addtitle>YAKUGAKU ZASSHI</addtitle><date>1985-05</date><risdate>1985</risdate><volume>105</volume><issue>5</issue><spage>470</spage><epage>474</epage><pages>470-474</pages><artnum>470</artnum><issn>0031-6903</issn><eissn>1347-5231</eissn><abstract>The decomposition compound formed by xenon irradiation of nafamstat mesilate in aqueous solution and its kinetics were studied and the following findings were obtained. Nafamstat mesilate was decomposed by xenon irradiation to form 4-guanidinobenzoic acid (PGBA), 6-amino-2-naphthol (AN) and compound II having yellow color. The structure of the compound II was studied in comparison with nafamstat mesilate by chemical and physical methods and shown to be an amide type compound of PGBA and AN. Photodemposition reaction of nafamstat mesilate was found to follow the pseudo-second order reaction.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>4032236</pmid><doi>10.1248/yakushi1947.105.5_470</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6903 |
| ispartof | YAKUGAKU ZASSHI, 1985/05/25, Vol.105(5), pp.470-474 |
| issn | 0031-6903 1347-5231 |
| language | eng ; jpn |
| recordid | cdi_proquest_miscellaneous_76286031 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Alma/SFX Local Collection |
| subjects | 4-guaninobenzoic acid 6-amidino-2-naphthol decomposition product Drug Stability Guanidines nafamstat mesilate Photolysis proteinase inhibitor Solutions Water |
| title | Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate |
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