Humoral Immunity in Infants with Gastroenteritis Caused by Human Calicivirus
To assess the serum immune response in infants with gastroenteritis caused by human calicivirus (HCV), we tested a total of 165 serum specimens for antibodies to HCV by a radioimmunoassay blocking (RIA-BL) test. The specificity of the RIA-BL test for antibody to HCV was established as follows: paire...
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| Veröffentlicht in: | The Journal of infectious diseases 1985-08, Vol.152 (2), p.274-279 |
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| container_title | The Journal of infectious diseases |
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| creator | Nakata, Shuji Chiba, Shunzo Terashima, Hideyuki Yokoyama, Takashi Nakao, Tooru |
| description | To assess the serum immune response in infants with gastroenteritis caused by human calicivirus (HCV), we tested a total of 165 serum specimens for antibodies to HCV by a radioimmunoassay blocking (RIA-BL) test. The specificity of the RIA-BL test for antibody to HCV was established as follows: paired sera from patients with HCV gastroenteritis revealed significant rises in antibody to HCV, whereas there was no significant change in RIA-BL titer to HCV in paired sera collected from the same individuals when infected with other gastroenteritis viruses. We analyzed 41 paired sera from patients and from healthy contacts involved in an outbreak of HCV gastroenteritis. All 23 infants without preexisting antibody revealed a sharp rise in HCV titer, and 18(73%) of 23 of them developed illness. Fifteen of 18 infants with preexisting antibody also revealed a significant rise in HCV antibody, but only 3 (16.7%) of 18 became ill (P |
| doi_str_mv | 10.1093/infdis/152.2.274 |
| format | Article |
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The specificity of the RIA-BL test for antibody to HCV was established as follows: paired sera from patients with HCV gastroenteritis revealed significant rises in antibody to HCV, whereas there was no significant change in RIA-BL titer to HCV in paired sera collected from the same individuals when infected with other gastroenteritis viruses. We analyzed 41 paired sera from patients and from healthy contacts involved in an outbreak of HCV gastroenteritis. All 23 infants without preexisting antibody revealed a sharp rise in HCV titer, and 18(73%) of 23 of them developed illness. Fifteen of 18 infants with preexisting antibody also revealed a significant rise in HCV antibody, but only 3 (16.7%) of 18 became ill (P <.01). These data suggest that the presence of serum antibody may correlate with resistance to illness in HCV gastroenteritis.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/152.2.274</identifier><identifier>PMID: 2993432</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibodies ; Antibodies, Viral - analysis ; Antibodies, Viral - biosynthesis ; Antigens ; Biological and medical sciences ; Caliciviridae - immunology ; Caliciviridae - isolation & purification ; calicivirus ; Diarrhea ; Diseases ; Gastroenteritis ; Gastroenteritis - immunology ; Gastroenteritis - microbiology ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Medical sciences ; Microscopy, Electron ; Original Articles ; Picornaviridae Infections - immunology ; Picornaviridae Infections - microbiology ; Radioimmunoassay ; Rotavirus ; Specimens ; Viral diseases ; Viral diseases of the digestive system ; Viruses ; Vomiting</subject><ispartof>The Journal of infectious diseases, 1985-08, Vol.152 (2), p.274-279</ispartof><rights>Copyright 1985 The University of Chicago</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-ec8f66bdd92cc3409d8b3c54d9e6a1b5a9a6aa778c7253441b6fb59afe10841c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30104676$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30104676$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8412001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2993432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakata, Shuji</creatorcontrib><creatorcontrib>Chiba, Shunzo</creatorcontrib><creatorcontrib>Terashima, Hideyuki</creatorcontrib><creatorcontrib>Yokoyama, Takashi</creatorcontrib><creatorcontrib>Nakao, Tooru</creatorcontrib><title>Humoral Immunity in Infants with Gastroenteritis Caused by Human Calicivirus</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To assess the serum immune response in infants with gastroenteritis caused by human calicivirus (HCV), we tested a total of 165 serum specimens for antibodies to HCV by a radioimmunoassay blocking (RIA-BL) test. The specificity of the RIA-BL test for antibody to HCV was established as follows: paired sera from patients with HCV gastroenteritis revealed significant rises in antibody to HCV, whereas there was no significant change in RIA-BL titer to HCV in paired sera collected from the same individuals when infected with other gastroenteritis viruses. We analyzed 41 paired sera from patients and from healthy contacts involved in an outbreak of HCV gastroenteritis. All 23 infants without preexisting antibody revealed a sharp rise in HCV titer, and 18(73%) of 23 of them developed illness. Fifteen of 18 infants with preexisting antibody also revealed a significant rise in HCV antibody, but only 3 (16.7%) of 18 became ill (P <.01). These data suggest that the presence of serum antibody may correlate with resistance to illness in HCV gastroenteritis.</description><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Caliciviridae - immunology</subject><subject>Caliciviridae - isolation & purification</subject><subject>calicivirus</subject><subject>Diarrhea</subject><subject>Diseases</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - immunology</subject><subject>Gastroenteritis - microbiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Original Articles</subject><subject>Picornaviridae Infections - immunology</subject><subject>Picornaviridae Infections - microbiology</subject><subject>Radioimmunoassay</subject><subject>Rotavirus</subject><subject>Specimens</subject><subject>Viral diseases</subject><subject>Viral diseases of the digestive system</subject><subject>Viruses</subject><subject>Vomiting</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAURS0EKkNhzwYpC8Qurb9ix0s6op0RI7EpEmJjvTiOcEmc4ucU5t_X1QzDEr2FZZ37ruxDyFtGLxg14jLEoQ94yRp-UUbLZ2TFGqFrpZh4TlaUcl6z1piX5BXiHaVUCqXPyBk3RkjBV2S3WaY5wVhtp2mJIe-rEKttHCBmrH6H_KO6Acxp9jH7FHLAag0L-r7q9lVZhVjuY3DhIaQFX5MXA4zo3xzPc_L1-tPtelPvvtxs1x93tZNM5tq7dlCq63vDnROSmr7thGtkb7wC1jVgQAFo3TrNGyEl69TQNQYGz2grmRPn5MOh9z7NvxaP2U4BnR9HiH5e0GrFS6588H9BJosIyUwJ0kPQpRkx-cHepzBB2ltG7ZNpezBti2lbRj91vzt2L93k-9PCUW3h748c0ME4JIiuFPyNlQdyStm_mjvMczphQRmVSqvC6wMPmP2fE4f00yotdGM3377b2-aKf76iO9uKR2dUoJQ</recordid><startdate>19850801</startdate><enddate>19850801</enddate><creator>Nakata, Shuji</creator><creator>Chiba, Shunzo</creator><creator>Terashima, Hideyuki</creator><creator>Yokoyama, Takashi</creator><creator>Nakao, Tooru</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850801</creationdate><title>Humoral Immunity in Infants with Gastroenteritis Caused by Human Calicivirus</title><author>Nakata, Shuji ; Chiba, Shunzo ; Terashima, Hideyuki ; Yokoyama, Takashi ; Nakao, Tooru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-ec8f66bdd92cc3409d8b3c54d9e6a1b5a9a6aa778c7253441b6fb59afe10841c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Caliciviridae - immunology</topic><topic>Caliciviridae - isolation & purification</topic><topic>calicivirus</topic><topic>Diarrhea</topic><topic>Diseases</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - immunology</topic><topic>Gastroenteritis - microbiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Original Articles</topic><topic>Picornaviridae Infections - immunology</topic><topic>Picornaviridae Infections - microbiology</topic><topic>Radioimmunoassay</topic><topic>Rotavirus</topic><topic>Specimens</topic><topic>Viral diseases</topic><topic>Viral diseases of the digestive system</topic><topic>Viruses</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakata, Shuji</creatorcontrib><creatorcontrib>Chiba, Shunzo</creatorcontrib><creatorcontrib>Terashima, Hideyuki</creatorcontrib><creatorcontrib>Yokoyama, Takashi</creatorcontrib><creatorcontrib>Nakao, Tooru</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakata, Shuji</au><au>Chiba, Shunzo</au><au>Terashima, Hideyuki</au><au>Yokoyama, Takashi</au><au>Nakao, Tooru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humoral Immunity in Infants with Gastroenteritis Caused by Human Calicivirus</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1985-08-01</date><risdate>1985</risdate><volume>152</volume><issue>2</issue><spage>274</spage><epage>279</epage><pages>274-279</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To assess the serum immune response in infants with gastroenteritis caused by human calicivirus (HCV), we tested a total of 165 serum specimens for antibodies to HCV by a radioimmunoassay blocking (RIA-BL) test. The specificity of the RIA-BL test for antibody to HCV was established as follows: paired sera from patients with HCV gastroenteritis revealed significant rises in antibody to HCV, whereas there was no significant change in RIA-BL titer to HCV in paired sera collected from the same individuals when infected with other gastroenteritis viruses. We analyzed 41 paired sera from patients and from healthy contacts involved in an outbreak of HCV gastroenteritis. All 23 infants without preexisting antibody revealed a sharp rise in HCV titer, and 18(73%) of 23 of them developed illness. Fifteen of 18 infants with preexisting antibody also revealed a significant rise in HCV antibody, but only 3 (16.7%) of 18 became ill (P <.01). These data suggest that the presence of serum antibody may correlate with resistance to illness in HCV gastroenteritis.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>2993432</pmid><doi>10.1093/infdis/152.2.274</doi><tpages>6</tpages></addata></record> |
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| subjects | Antibodies Antibodies, Viral - analysis Antibodies, Viral - biosynthesis Antigens Biological and medical sciences Caliciviridae - immunology Caliciviridae - isolation & purification calicivirus Diarrhea Diseases Gastroenteritis Gastroenteritis - immunology Gastroenteritis - microbiology Human viral diseases Humans Infant Infant, Newborn Infections Infectious diseases Medical sciences Microscopy, Electron Original Articles Picornaviridae Infections - immunology Picornaviridae Infections - microbiology Radioimmunoassay Rotavirus Specimens Viral diseases Viral diseases of the digestive system Viruses Vomiting |
| title | Humoral Immunity in Infants with Gastroenteritis Caused by Human Calicivirus |
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