Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides
Achyranthes bidentata polysaccharides (ABP), isolated from the root of Achyranthes bidentata Blume, 50 mg.kg-1 ip or 250 mg.kg-1 to ICR mice inhibited the growth of sarcoma 180. ABP 50 and 100 mg.kg-1 ip prolongated the survival days of mice bearing Ehrlich carcinoma. ABP 50-800 micrograms.ml-1 did...
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| Veröffentlicht in: | Zhōngguó yàolĭ xuébào 1993-11, Vol.14 (6), p.556-561 |
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| container_title | Zhōngguó yàolĭ xuébào |
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| creator | Xiang, D B Li, X Y |
| description | Achyranthes bidentata polysaccharides (ABP), isolated from the root of Achyranthes bidentata Blume, 50 mg.kg-1 ip or 250 mg.kg-1 to ICR mice inhibited the growth of sarcoma 180. ABP 50 and 100 mg.kg-1 ip prolongated the survival days of mice bearing Ehrlich carcinoma. ABP 50-800 micrograms.ml-1 did not exert direct cytotoxic effect in vitro on S180 cells, but enhanced the cytotoxicity of peritoneal macrophages against S180 cells. ABP 50 mg.kg-1 ip x 17 d or 250 mg.kg-1 ig x 16 d promoted the plaque forming cells (PFC) response to sheep red blood cells (SRBC) and serum IgG level as well as splenocyte proliferation induced by mitogen Con A or LPS in tumor-induced immunodeficient mice. ABP also elevated the NK cell activity and serum TNF content in mice bearing S180. These results indicated that the antitumor effect of ABP may be related to its potentiating effect on both specific and nonspecific host immunological responses. |
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ABP 50 and 100 mg.kg-1 ip prolongated the survival days of mice bearing Ehrlich carcinoma. ABP 50-800 micrograms.ml-1 did not exert direct cytotoxic effect in vitro on S180 cells, but enhanced the cytotoxicity of peritoneal macrophages against S180 cells. ABP 50 mg.kg-1 ip x 17 d or 250 mg.kg-1 ig x 16 d promoted the plaque forming cells (PFC) response to sheep red blood cells (SRBC) and serum IgG level as well as splenocyte proliferation induced by mitogen Con A or LPS in tumor-induced immunodeficient mice. ABP also elevated the NK cell activity and serum TNF content in mice bearing S180. These results indicated that the antitumor effect of ABP may be related to its potentiating effect on both specific and nonspecific host immunological responses.</description><identifier>ISSN: 0253-9756</identifier><identifier>PMID: 8010059</identifier><language>eng</language><publisher>Beijing: Science Press</publisher><subject>Adjuvants, Immunologic - pharmacology ; Animals ; Biological and medical sciences ; Carcinoma, Ehrlich Tumor - immunology ; Cytotoxicity, Immunologic ; Drugs, Chinese Herbal - chemistry ; General pharmacology ; Immunoglobulin G - blood ; Killer Cells, Natural - immunology ; Macrophages, Peritoneal - immunology ; Medical sciences ; Mice ; Mice, Inbred ICR ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Polysaccharides - pharmacology ; Sarcoma 180 - immunology ; Sarcoma 180 - pathology ; Tumor Cells, Cultured - immunology ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Zhōngguó yàolĭ xuébào, 1993-11, Vol.14 (6), p.556-561</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3838024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8010059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiang, D B</creatorcontrib><creatorcontrib>Li, X Y</creatorcontrib><title>Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides</title><title>Zhōngguó yàolĭ xuébào</title><addtitle>Zhongguo Yao Li Xue Bao</addtitle><description>Achyranthes bidentata polysaccharides (ABP), isolated from the root of Achyranthes bidentata Blume, 50 mg.kg-1 ip or 250 mg.kg-1 to ICR mice inhibited the growth of sarcoma 180. ABP 50 and 100 mg.kg-1 ip prolongated the survival days of mice bearing Ehrlich carcinoma. ABP 50-800 micrograms.ml-1 did not exert direct cytotoxic effect in vitro on S180 cells, but enhanced the cytotoxicity of peritoneal macrophages against S180 cells. ABP 50 mg.kg-1 ip x 17 d or 250 mg.kg-1 ig x 16 d promoted the plaque forming cells (PFC) response to sheep red blood cells (SRBC) and serum IgG level as well as splenocyte proliferation induced by mitogen Con A or LPS in tumor-induced immunodeficient mice. ABP also elevated the NK cell activity and serum TNF content in mice bearing S180. These results indicated that the antitumor effect of ABP may be related to its potentiating effect on both specific and nonspecific host immunological responses.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Ehrlich Tumor - immunology</subject><subject>Cytotoxicity, Immunologic</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>General pharmacology</subject><subject>Immunoglobulin G - blood</subject><subject>Killer Cells, Natural - immunology</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Polysaccharides - pharmacology</subject><subject>Sarcoma 180 - immunology</subject><subject>Sarcoma 180 - pathology</subject><subject>Tumor Cells, Cultured - immunology</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0253-9756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1LxDAQBuAclHVZ9ycIOYi3QpqPNj2WxS9Y8KInD2WapDbSJrVJhf57gxbnMjDvw8DMBdoTKlhWlaK4QscQPkmqgpaSVju0kyQnRFR79F67aOMy-hmDivbbxhWD09iO4-J8NvloEoBo3ccv8C5g3-Fa9esMLvYm4NbqZCACnvywBlCqhznNwjW67GAI5rj1A3p7uH89PWXnl8fnU33OJspEzJiiuTK5yDWpBBMgCFeESQ5522opWiOoaLlkuuh0wZjgktNOlWCM4oSAZAd097d3mv3XYkJsRhuUGQZwxi-hKQsqmaxYgjcbXNrR6Gaa7Qjz2mzfSPntlkNQMHTpQmXDP2NpC6Gc_QCqsmlt</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Xiang, D B</creator><creator>Li, X Y</creator><general>Science Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19931101</creationdate><title>Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides</title><author>Xiang, D B ; Li, X Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-3c21ce151d09535a504c0384a1bbd85be525b483d6fd63354842fc7aeec400a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Ehrlich Tumor - immunology</topic><topic>Cytotoxicity, Immunologic</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>General pharmacology</topic><topic>Immunoglobulin G - blood</topic><topic>Killer Cells, Natural - immunology</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Polysaccharides - pharmacology</topic><topic>Sarcoma 180 - immunology</topic><topic>Sarcoma 180 - pathology</topic><topic>Tumor Cells, Cultured - immunology</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiang, D B</creatorcontrib><creatorcontrib>Li, X Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhōngguó yàolĭ xuébào</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiang, D B</au><au>Li, X Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides</atitle><jtitle>Zhōngguó yàolĭ xuébào</jtitle><addtitle>Zhongguo Yao Li Xue Bao</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>14</volume><issue>6</issue><spage>556</spage><epage>561</epage><pages>556-561</pages><issn>0253-9756</issn><abstract>Achyranthes bidentata polysaccharides (ABP), isolated from the root of Achyranthes bidentata Blume, 50 mg.kg-1 ip or 250 mg.kg-1 to ICR mice inhibited the growth of sarcoma 180. ABP 50 and 100 mg.kg-1 ip prolongated the survival days of mice bearing Ehrlich carcinoma. ABP 50-800 micrograms.ml-1 did not exert direct cytotoxic effect in vitro on S180 cells, but enhanced the cytotoxicity of peritoneal macrophages against S180 cells. ABP 50 mg.kg-1 ip x 17 d or 250 mg.kg-1 ig x 16 d promoted the plaque forming cells (PFC) response to sheep red blood cells (SRBC) and serum IgG level as well as splenocyte proliferation induced by mitogen Con A or LPS in tumor-induced immunodeficient mice. ABP also elevated the NK cell activity and serum TNF content in mice bearing S180. These results indicated that the antitumor effect of ABP may be related to its potentiating effect on both specific and nonspecific host immunological responses.</abstract><cop>Beijing</cop><pub>Science Press</pub><pmid>8010059</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Zhōngguó yàolĭ xuébào, 1993-11, Vol.14 (6), p.556-561 |
| issn | 0253-9756 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic - pharmacology Animals Biological and medical sciences Carcinoma, Ehrlich Tumor - immunology Cytotoxicity, Immunologic Drugs, Chinese Herbal - chemistry General pharmacology Immunoglobulin G - blood Killer Cells, Natural - immunology Macrophages, Peritoneal - immunology Medical sciences Mice Mice, Inbred ICR Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Polysaccharides - pharmacology Sarcoma 180 - immunology Sarcoma 180 - pathology Tumor Cells, Cultured - immunology Tumor Necrosis Factor-alpha - biosynthesis |
| title | Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides |
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