The Characteristics of Blood-Borne Radiolabels and the Effect of Anti-Mouse IgG Antibodies on Localization of Radiolabeled Monoclonal Antibody in Cancer Patients
Quantitative and qualitative aspects of the blood survival of 131I and 111In-labeled monoclonal antibody 791T/36 have been examined in patients with colo-rectal carcinoma, ovarian carcinoma and osteogenic sarcoma who were receiving labeled antibody in diagnostic immunoscintigraphy trials. The blood...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1985-09, Vol.26 (9), p.1011-1023 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Pimm, Malcolm V Perkins, Alan C Armitage, Nicholas C Baldwin, Robert W |
| description | Quantitative and qualitative aspects of the blood survival of 131I and 111In-labeled monoclonal antibody 791T/36 have been examined in patients with colo-rectal carcinoma, ovarian carcinoma and osteogenic sarcoma who were receiving labeled antibody in diagnostic immunoscintigraphy trials. The blood clearance of intact antibody radiolabeled with either 131I or 111In was similar. A bi-phasic decline of both radiolabeled preparations was measured with initial half-lives 0.62 and 0.42 days for 131I and 111In labels and then with 1.85 and 1.40 day half-lives, respectively. The Fab fragment of the antibody was lost more rapidly (initial half-life 0.20 days and then 0.78 days). Blood-borne radioactivity was associated predominantly with plasma rather than cellular elements. Radioactivity was still attached to undegraded, uncomplexed, and immunologically active antibody as demonstrated by molecular filtration, immune precipitation, and antigen binding assays. However, anti-mouse-IgG antibody detected within 7 days of administration of radiolabeled antibody was present for at least 10 mo and has implications for the efficiency of repeated image studies. |
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The blood clearance of intact antibody radiolabeled with either 131I or 111In was similar. A bi-phasic decline of both radiolabeled preparations was measured with initial half-lives 0.62 and 0.42 days for 131I and 111In labels and then with 1.85 and 1.40 day half-lives, respectively. The Fab fragment of the antibody was lost more rapidly (initial half-life 0.20 days and then 0.78 days). Blood-borne radioactivity was associated predominantly with plasma rather than cellular elements. Radioactivity was still attached to undegraded, uncomplexed, and immunologically active antibody as demonstrated by molecular filtration, immune precipitation, and antigen binding assays. However, anti-mouse-IgG antibody detected within 7 days of administration of radiolabeled antibody was present for at least 10 mo and has implications for the efficiency of repeated image studies.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 3861794</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Animals ; Antibodies, Monoclonal - analysis ; Antigen-Antibody Complex - analysis ; Binding, Competitive ; Chromatography, Gel ; Colonic Neoplasms - blood ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - diagnostic imaging ; Female ; Humans ; Immunoglobulin Fab Fragments - analysis ; Immunoglobulin G - analysis ; Indium ; Iodine Radioisotopes ; Isotope Labeling ; Mice ; Neoplasms - blood ; Neoplasms - diagnosis ; Neoplasms - diagnostic imaging ; Osteosarcoma - blood ; Osteosarcoma - diagnosis ; Osteosarcoma - diagnostic imaging ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - diagnostic imaging ; Radioisotopes ; Radionuclide Imaging ; Rectal Neoplasms - blood ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - diagnostic imaging</subject><ispartof>The Journal of nuclear medicine (1978), 1985-09, Vol.26 (9), p.1011-1023</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3861794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pimm, Malcolm V</creatorcontrib><creatorcontrib>Perkins, Alan C</creatorcontrib><creatorcontrib>Armitage, Nicholas C</creatorcontrib><creatorcontrib>Baldwin, Robert W</creatorcontrib><title>The Characteristics of Blood-Borne Radiolabels and the Effect of Anti-Mouse IgG Antibodies on Localization of Radiolabeled Monoclonal Antibody in Cancer Patients</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Quantitative and qualitative aspects of the blood survival of 131I and 111In-labeled monoclonal antibody 791T/36 have been examined in patients with colo-rectal carcinoma, ovarian carcinoma and osteogenic sarcoma who were receiving labeled antibody in diagnostic immunoscintigraphy trials. The blood clearance of intact antibody radiolabeled with either 131I or 111In was similar. A bi-phasic decline of both radiolabeled preparations was measured with initial half-lives 0.62 and 0.42 days for 131I and 111In labels and then with 1.85 and 1.40 day half-lives, respectively. The Fab fragment of the antibody was lost more rapidly (initial half-life 0.20 days and then 0.78 days). Blood-borne radioactivity was associated predominantly with plasma rather than cellular elements. Radioactivity was still attached to undegraded, uncomplexed, and immunologically active antibody as demonstrated by molecular filtration, immune precipitation, and antigen binding assays. However, anti-mouse-IgG antibody detected within 7 days of administration of radiolabeled antibody was present for at least 10 mo and has implications for the efficiency of repeated image studies.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - analysis</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Binding, Competitive</subject><subject>Chromatography, Gel</subject><subject>Colonic Neoplasms - blood</subject><subject>Colonic Neoplasms - diagnosis</subject><subject>Colonic Neoplasms - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin Fab Fragments - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Indium</subject><subject>Iodine Radioisotopes</subject><subject>Isotope Labeling</subject><subject>Mice</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Osteosarcoma - blood</subject><subject>Osteosarcoma - diagnosis</subject><subject>Osteosarcoma - diagnostic imaging</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Radioisotopes</subject><subject>Radionuclide Imaging</subject><subject>Rectal Neoplasms - blood</subject><subject>Rectal Neoplasms - diagnosis</subject><subject>Rectal Neoplasms - diagnostic imaging</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN1qGzEQhZfSkDpuH6Ggq_ZqYfUvX9omTQIOLcG9Xma1s1kZWXIlmZK-Td6068QhNzMczncOzHyoZlRyWUul9Mdq1lBFaykb-am6ynnXNI0yxlxWl9woqhdiVj1vRyTrERLYgsnl4mwmcSArH2Nfr2IKSB6gd9FDhz4TCD0pU-R6GNCWE7kMxdX38ZiR3D3evMgu9g6nmkA20YJ3_6C4SUzwexX25D6GaH0M4N9ST8QFsoZgMZFfUwhDyZ-riwF8xi_nPa9-_7jerm_rzc-bu_VyU4-Mm1ILozuptWQNSMGUBN0PwiysHTTtmKFcK96fhu0MY4waAwo4CKH5QgiQfF59e-09pPjniLm0e5cteg8Bp-tarZjhgp_Ar2fw2O2xbw_J7SE9teefTv73V390j-Nfl7ANR-sR0gnehT1T7aKlDaX8P3C9gec</recordid><startdate>198509</startdate><enddate>198509</enddate><creator>Pimm, Malcolm V</creator><creator>Perkins, Alan C</creator><creator>Armitage, Nicholas C</creator><creator>Baldwin, Robert W</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198509</creationdate><title>The Characteristics of Blood-Borne Radiolabels and the Effect of Anti-Mouse IgG Antibodies on Localization of Radiolabeled Monoclonal Antibody in Cancer Patients</title><author>Pimm, Malcolm V ; Perkins, Alan C ; Armitage, Nicholas C ; Baldwin, Robert W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-487b577520a54265a7df489ccf71b2813763d3763cb8222188a6a3a4473944a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - analysis</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Binding, Competitive</topic><topic>Chromatography, Gel</topic><topic>Colonic Neoplasms - blood</topic><topic>Colonic Neoplasms - diagnosis</topic><topic>Colonic Neoplasms - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin Fab Fragments - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Indium</topic><topic>Iodine Radioisotopes</topic><topic>Isotope Labeling</topic><topic>Mice</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Osteosarcoma - blood</topic><topic>Osteosarcoma - diagnosis</topic><topic>Osteosarcoma - diagnostic imaging</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovarian Neoplasms - diagnostic imaging</topic><topic>Radioisotopes</topic><topic>Radionuclide Imaging</topic><topic>Rectal Neoplasms - blood</topic><topic>Rectal Neoplasms - diagnosis</topic><topic>Rectal Neoplasms - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pimm, Malcolm V</creatorcontrib><creatorcontrib>Perkins, Alan C</creatorcontrib><creatorcontrib>Armitage, Nicholas C</creatorcontrib><creatorcontrib>Baldwin, Robert W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pimm, Malcolm V</au><au>Perkins, Alan C</au><au>Armitage, Nicholas C</au><au>Baldwin, Robert W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Characteristics of Blood-Borne Radiolabels and the Effect of Anti-Mouse IgG Antibodies on Localization of Radiolabeled Monoclonal Antibody in Cancer Patients</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1985-09</date><risdate>1985</risdate><volume>26</volume><issue>9</issue><spage>1011</spage><epage>1023</epage><pages>1011-1023</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Quantitative and qualitative aspects of the blood survival of 131I and 111In-labeled monoclonal antibody 791T/36 have been examined in patients with colo-rectal carcinoma, ovarian carcinoma and osteogenic sarcoma who were receiving labeled antibody in diagnostic immunoscintigraphy trials. The blood clearance of intact antibody radiolabeled with either 131I or 111In was similar. A bi-phasic decline of both radiolabeled preparations was measured with initial half-lives 0.62 and 0.42 days for 131I and 111In labels and then with 1.85 and 1.40 day half-lives, respectively. The Fab fragment of the antibody was lost more rapidly (initial half-life 0.20 days and then 0.78 days). Blood-borne radioactivity was associated predominantly with plasma rather than cellular elements. Radioactivity was still attached to undegraded, uncomplexed, and immunologically active antibody as demonstrated by molecular filtration, immune precipitation, and antigen binding assays. However, anti-mouse-IgG antibody detected within 7 days of administration of radiolabeled antibody was present for at least 10 mo and has implications for the efficiency of repeated image studies.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>3861794</pmid><tpages>13</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1985-09, Vol.26 (9), p.1011-1023 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Monoclonal - analysis Antigen-Antibody Complex - analysis Binding, Competitive Chromatography, Gel Colonic Neoplasms - blood Colonic Neoplasms - diagnosis Colonic Neoplasms - diagnostic imaging Female Humans Immunoglobulin Fab Fragments - analysis Immunoglobulin G - analysis Indium Iodine Radioisotopes Isotope Labeling Mice Neoplasms - blood Neoplasms - diagnosis Neoplasms - diagnostic imaging Osteosarcoma - blood Osteosarcoma - diagnosis Osteosarcoma - diagnostic imaging Ovarian Neoplasms - blood Ovarian Neoplasms - diagnosis Ovarian Neoplasms - diagnostic imaging Radioisotopes Radionuclide Imaging Rectal Neoplasms - blood Rectal Neoplasms - diagnosis Rectal Neoplasms - diagnostic imaging |
| title | The Characteristics of Blood-Borne Radiolabels and the Effect of Anti-Mouse IgG Antibodies on Localization of Radiolabeled Monoclonal Antibody in Cancer Patients |
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