Penicillinase-producing Neisseria gonorrhoeae: epidemiology, antimicrobial susceptibility and plasmid types
Between 1976 and 1984 204 infections by penicillinase-producing Neisseria gonorrhoeae (PPNG) were seen in the Whitechapel Clinic. In 1984 PPNG were isolated from 4·7% of all patients attending with gonorrhoea. Three infections were homosexually acquired; 140 infections (68%) were acquired in the U.K...
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| Veröffentlicht in: | The Journal of infection 1985-01, Vol.11 (1), p.63-69 |
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| creator | Goh, B.T. Rodin, P. Johnston, N.A. Wong, H.H.Y. |
| description | Between 1976 and 1984 204 infections by penicillinase-producing
Neisseria gonorrhoeae (PPNG) were seen in the Whitechapel Clinic. In 1984 PPNG were isolated from 4·7% of all patients attending with gonorrhoea. Three infections were homosexually acquired; 140 infections (68%) were acquired in the U.K. Strains that were tested were fully sensitive to spectinomycin (190), cefuroxime (177), kanamycin (170), amoxycillin combined with clavulanic acid (24) and rosoxacin (18). Of 135 strains 61% were resistant to co-trimoxazole, 69% of 169 to tetracycline (MIC ⩾ 1 mg/1) and 32% of 75 to streptomycin. Of 109 strains subjected to plasmid typing, 72(66%) were Asian strains. Of these, 55 (50% of the total) were without and 17 (16% of the total) possessed the 24·5 Mdal transfer plasmid; 27 (25%) were African strains without and 10 (9%) with the transfer plasmid. Of the Asian strains 10 were acquired in Africa. All four plasmid-containing strains are now endemic in the U.K. On the basis of the sensitivity tests, spectinomycin, cefuroxime and kanamycin should be effective in treatment, but not co-trimoxazole and tetracycline. |
| doi_str_mv | 10.1016/S0163-4453(85)91094-1 |
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Neisseria gonorrhoeae (PPNG) were seen in the Whitechapel Clinic. In 1984 PPNG were isolated from 4·7% of all patients attending with gonorrhoea. Three infections were homosexually acquired; 140 infections (68%) were acquired in the U.K. Strains that were tested were fully sensitive to spectinomycin (190), cefuroxime (177), kanamycin (170), amoxycillin combined with clavulanic acid (24) and rosoxacin (18). Of 135 strains 61% were resistant to co-trimoxazole, 69% of 169 to tetracycline (MIC ⩾ 1 mg/1) and 32% of 75 to streptomycin. Of 109 strains subjected to plasmid typing, 72(66%) were Asian strains. Of these, 55 (50% of the total) were without and 17 (16% of the total) possessed the 24·5 Mdal transfer plasmid; 27 (25%) were African strains without and 10 (9%) with the transfer plasmid. Of the Asian strains 10 were acquired in Africa. All four plasmid-containing strains are now endemic in the U.K. On the basis of the sensitivity tests, spectinomycin, cefuroxime and kanamycin should be effective in treatment, but not co-trimoxazole and tetracycline.</description><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Drug Combinations - pharmacology</subject><subject>Drug Resistance, Microbial</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonorrhea - drug therapy</subject><subject>Gonorrhea - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Neisseria gonorrhoeae - drug effects</subject><subject>Neisseria gonorrhoeae - enzymology</subject><subject>Neisseria gonorrhoeae - genetics</subject><subject>Penicillinase - biosynthesis</subject><subject>Plasmids</subject><subject>Streptomycin - pharmacology</subject><subject>Sulfamethoxazole - pharmacology</subject><subject>Tetracycline - pharmacology</subject><subject>Trimethoprim - pharmacology</subject><subject>Trimethoprim, Sulfamethoxazole Drug Combination</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVuLFDEQhYMo67j6Exb6QUTB1tw78UVk8QaLCupzSCfVY2n6YtIjzL83szPM676kHs5XlTp1CLli9BWjTL_-Xh_RSqnEc6NeWEatbNk9smFK8JZ3kt8nmzPykDwq5Tel1AqrL8iFsNx0Wm_In28wYcCUcPIF2iXPcRdw2jZfAEuBjL7ZztOc868ZPLxpYMEII85p3u5fNn5accSQ5x59asquBFhW7DHhuq9ibJbky4ixWfcLlMfkweBTgSenekl-fnj_4_pTe_P14-frdzdtkJyurYrDYDsruDaqGmC816yzIXZe9IPkKlLaBykZUKWj99QG7Vln-k5pxmKw4pI8O86tbv7uoKxuxLpZSn6CeVdcp7nhtBN3gkwKa5TpKqiOYLVaSobBLRlHn_eOUXdIw92m4Q6ndka52zQcq31Xpw92_Qjx3HU6f9WfnnRfgk9D9lPAcsaMkoaZw5i3Rwzq1f4hZFcCwhQgYoawujjjHYv8B9igqBE</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Goh, B.T.</creator><creator>Rodin, P.</creator><creator>Johnston, N.A.</creator><creator>Wong, H.H.Y.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Penicillinase-producing Neisseria gonorrhoeae: epidemiology, antimicrobial susceptibility and plasmid types</title><author>Goh, B.T. ; Rodin, P. ; Johnston, N.A. ; Wong, H.H.Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5dff9793268501612b6179cd7a3bf425d00bc441e056daa09c6a178b75611dc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Drug Combinations - pharmacology</topic><topic>Drug Resistance, Microbial</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonorrhea - drug therapy</topic><topic>Gonorrhea - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Neisseria gonorrhoeae - drug effects</topic><topic>Neisseria gonorrhoeae - enzymology</topic><topic>Neisseria gonorrhoeae - genetics</topic><topic>Penicillinase - biosynthesis</topic><topic>Plasmids</topic><topic>Streptomycin - pharmacology</topic><topic>Sulfamethoxazole - pharmacology</topic><topic>Tetracycline - pharmacology</topic><topic>Trimethoprim - pharmacology</topic><topic>Trimethoprim, Sulfamethoxazole Drug Combination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goh, B.T.</creatorcontrib><creatorcontrib>Rodin, P.</creatorcontrib><creatorcontrib>Johnston, N.A.</creatorcontrib><creatorcontrib>Wong, H.H.Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goh, B.T.</au><au>Rodin, P.</au><au>Johnston, N.A.</au><au>Wong, H.H.Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Penicillinase-producing Neisseria gonorrhoeae: epidemiology, antimicrobial susceptibility and plasmid types</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>11</volume><issue>1</issue><spage>63</spage><epage>69</epage><pages>63-69</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><coden>JINFD2</coden><abstract>Between 1976 and 1984 204 infections by penicillinase-producing
Neisseria gonorrhoeae (PPNG) were seen in the Whitechapel Clinic. In 1984 PPNG were isolated from 4·7% of all patients attending with gonorrhoea. Three infections were homosexually acquired; 140 infections (68%) were acquired in the U.K. Strains that were tested were fully sensitive to spectinomycin (190), cefuroxime (177), kanamycin (170), amoxycillin combined with clavulanic acid (24) and rosoxacin (18). Of 135 strains 61% were resistant to co-trimoxazole, 69% of 169 to tetracycline (MIC ⩾ 1 mg/1) and 32% of 75 to streptomycin. Of 109 strains subjected to plasmid typing, 72(66%) were Asian strains. Of these, 55 (50% of the total) were without and 17 (16% of the total) possessed the 24·5 Mdal transfer plasmid; 27 (25%) were African strains without and 10 (9%) with the transfer plasmid. Of the Asian strains 10 were acquired in Africa. All four plasmid-containing strains are now endemic in the U.K. On the basis of the sensitivity tests, spectinomycin, cefuroxime and kanamycin should be effective in treatment, but not co-trimoxazole and tetracycline.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>3928766</pmid><doi>10.1016/S0163-4453(85)91094-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Bacteriology Biological and medical sciences Drug Combinations - pharmacology Drug Resistance, Microbial Epidemiology Female Fundamental and applied biological sciences. Psychology Gonorrhea - drug therapy Gonorrhea - epidemiology Humans Male Microbial Sensitivity Tests Microbiology Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - enzymology Neisseria gonorrhoeae - genetics Penicillinase - biosynthesis Plasmids Streptomycin - pharmacology Sulfamethoxazole - pharmacology Tetracycline - pharmacology Trimethoprim - pharmacology Trimethoprim, Sulfamethoxazole Drug Combination |
| title | Penicillinase-producing Neisseria gonorrhoeae: epidemiology, antimicrobial susceptibility and plasmid types |
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